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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045928
UUCD1 version UUC-HoS-00977
Ensembl Protein ID ENSP00000338807.4
UniProt Accession Q6ZSB9; A8K936; Q32ML0; Q59FJ4; Q5EBN0; Q8TB80; ZBT49_HUMAN
Genbank Protein ID BAC87035.1; BAF85240.1; AAH16477.1; AAH89401.1; AAI09088.1; BAD92703.1
Protein Name Zinc finger and BTB domain-containing protein 49; Zinc finger protein 509
Genbank Nucleotide ID AK127560; AK292551; AC011744; BC089401; BC109087; AB209466
Gene Name ZBTB49; ZNF509
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168826.15 ENST00000515012.5 ENSP00000422321.1
ENSG00000168826.15 ENST00000337872.8 ENSP00000338807.4
ENSG00000168826.15 ENST00000503703.5 ENSP00000424525.1
ENSG00000168826.15 ENST00000504302.1 ENSP00000421654.1
ENSG00000168826.15 ENST00000511458.1 ENSP00000426765.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.80e-12 49.1 25 90
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D++lvv+g+ f+ahk vLaa S++F++lf++  ++++     ++k    +   ++l+F+Yt+ ld+n
   Q: 25   CDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDVK--NVSGIGQILDFMYTSHLDLN 90
           8*****************************9988876545555555..8899**************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.
 Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.
Protein Sequence
(Fasta)
MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF RSLFQNSSSQ 60
KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT AQCLQVQNVL SLCHTFLKSA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045928|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTGTCGTGA TGATTCCGCG GCCAGCGGAT CGCTGCGAGT GGCCTTGAAG GCAGCTGCTG 60
CAGGTGAAGA GTAGGCGGCG GGGCAGAGAG CGGCCTCCGA GGGTAAGGTG GCCGGCCTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045928|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR020542--Asp_carbamoyltrfase_reg_C
IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0015630--C:microtubule cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0001223--F:transcription coactivator binding
GO:0008134--F:transcription factor binding
GO:0007050--P:cell cycle arrest
GO:0008285--P:negative regulation of cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG hsa:166793
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002380 Ailuropoda melanoleuca 80.26 0.00e+00 1192.00
IUUC-Apl-003402 Anas platyrhynchos 73.27 0.00e+00 1129.00
IUUC-Aca-005251 Anolis carolinensis 58.63 0.00e+00 842.00
IUUC-Ame-011624 Astyanax mexicanus 78.87 6.00e-97 348.00
IUUC-Bta-013500 Bos taurus 80.16 0.00e+00 1186.00
IUUC-Cja-019265 Callithrix jacchus 92.69 0.00e+00 1370.00
IUUC-Cfa-020468 Canis familiaris 81.46 0.00e+00 1206.00
IUUC-Cpo-021937 Cavia porcellus 74.25 0.00e+00 1038.00
IUUC-Csa-023216 Chlorocebus sabaeus 96.87 0.00e+00 1452.00
IUUC-Dre-028348 Danio rerio 75.00 1.00e-96 347.00
IUUC-Dno-029339 Dasypus novemcinctus 82.51 0.00e+00 1231.00
IUUC-Dor-030277 Dipodomys ordii 83.11 4.00e-105 375.00
IUUC-Dme-032129 Drosophila melanogaster 49.40 6.00e-20 94.00
IUUC-Eca-033669 Equus caballus 83.92 0.00e+00 1261.00
IUUC-Fca-035639 Felis catus 71.91 0.00e+00 1009.00
IUUC-Fal-037462 Ficedula albicollis 68.36 0.00e+00 979.00
IUUC-Gmo-039476 Gadus morhua 71.49 4.00e-92 332.00
IUUC-Gac-041549 Gasterosteus aculeatus 46.57 2.00e-169 589.00
IUUC-Ggo-044866 Gorilla gorilla 99.09 0.00e+00 1487.00
IUUC-Itr-048707 Ictidomys tridecemlineatus 83.53 0.00e+00 1179.00
IUUC-Lch-050388 Latimeria chalumnae 56.96 0.00e+00 859.00
IUUC-Loc-052002 Lepisosteus oculatus 52.60 0.00e+00 709.00
IUUC-Laf-054184 Loxodonta africana 81.46 0.00e+00 1196.00
IUUC-Mcc-055715 Macaca mulatta 97.26 0.00e+00 1457.00
IUUC-Mga-059724 Meleagris gallopavo 73.14 0.00e+00 1127.00
IUUC-Mdo-062942 Monodelphis domestica 75.91 0.00e+00 1118.00
IUUC-Mmu-064042 Mus musculus 74.28 0.00e+00 1085.00
IUUC-Mpu-066682 Mustela putorius furo 74.22 4.00e-176 610.00
IUUC-Mlu-068067 Myotis lucifugus 76.86 0.00e+00 1185.00
IUUC-Nle-070108 Nomascus leucogenys 97.91 0.00e+00 1466.00
IUUC-Opr-070475 Ochotona princeps 70.18 0.00e+00 962.00
IUUC-Ont-072124 Oreochromis niloticus 45.74 5.00e-174 604.00
IUUC-Oan-073392 Ornithorhynchus anatinus 56.83 1.00e-66 247.00
IUUC-Ocu-074120 Oryctolagus cuniculus 75.10 0.00e+00 1064.00
IUUC-Ola-087133 Oryzias latipes 45.04 3.00e-161 562.00
IUUC-Oga-088105 Otolemur garnettii 85.36 0.00e+00 1290.00
IUUC-Oar-089685 Ovis aries 62.44 0.00e+00 687.00
IUUC-Ptr-090971 Pan troglodytes 99.74 0.00e+00 1493.00
IUUC-Pan-092567 Papio anubis 96.74 0.00e+00 1441.00
IUUC-Psi-093775 Pelodiscus sinensis 74.71 0.00e+00 1109.00
IUUC-Pma-094193 Petromyzon marinus 55.70 6.00e-47 181.00
IUUC-Pfo-096353 Poecilia formosa 45.59 6.00e-164 571.00
IUUC-Pab-097617 Pongo abelii 97.91 0.00e+00 1469.00
IUUC-Pva-102633 Pteropus vampyrus 78.82 0.00e+00 1170.00
IUUC-Rno-105385 Rattus norvegicus 72.32 0.00e+00 1056.00
IUUC-Sha-107166 Sarcophilus harrisii 67.96 0.00e+00 954.00
IUUC-Sar-113012 Sorex araneus 72.09 0.00e+00 756.00
IUUC-Ssc-116285 Sus scrofa 76.53 0.00e+00 1114.00
IUUC-Tgu-117060 Taeniopygia guttata 70.87 0.00e+00 1054.00
IUUC-Tru-118102 Takifugu rubripes 45.69 7.00e-162 564.00
IUUC-Tni-120447 Tetraodon nigroviridis 52.97 2.00e-156 546.00
IUUC-Tbe-127463 Tupaia belangeri 84.69 0.00e+00 677.00
IUUC-Ttr-128785 Tursiops truncatus 82.11 0.00e+00 1232.00
IUUC-Vpa-130467 Vicugna pacos 79.58 0.00e+00 785.00
IUUC-Xtr-131986 Xenopus tropicalis 53.33 3.00e-149 522.00
Created Date 25-Jun-2017

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