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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046974
Ensembl Protein ID ENSP00000354218.4
UniProt Accession Q8WUF5; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290; IASPP_HUMAN
Genbank Protein ID CAI60219.1; AAW51146.1; ABC40745.1; AAH01475.1; AAH20589.1; AAH32298.1; AAH64913.1; AAD27004.1; AAD27005.1
Protein Name RelA-associated inhibitor; Inhibitor of ASPP protein; NFkB-interacting protein 1; PPP1R13B-like protein
Genbank Nucleotide ID AJ888472; AY869712; DQ314886; BC001475; BC020589; BC032298; BC064913; AF078036; AF078037
Gene Name PPP1R13L; IASPP; NKIP1; PPP1R13BL; RAI
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000104881.15 ENST00000360957.9 ENSP00000354218.4
ENSG00000104881.15 ENST00000589371.1 ENSP00000466555.1
ENSG00000104881.15 ENST00000591986.1 ENSP00000466939.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 5.10e-10 40.8 762 814
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPenF 58
            v +l+dy+a+  deL++++G+ v+v+  +  ++ +W+ +   l+g++G +P n+
   Q: 762  AVYALWDYSAEFGDELSFREGESVTVLrRDGPEETDWWWA--ALHGQEGYVPRNY 814
           5889***********************8777788999999..8***********9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
 Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
Protein Sequence
(Fasta)
MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW SDSPAPPGPQ 60
AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS ESAPTLHPYS PLSPKGRPSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046974|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
CTTCCTAAGC CTTAAAGAGA CAGGACGGTC GATTGGTCTG AAATTCTTGA AGAGACAGGT 60
AAGAATACTA GTTAGTAGGG CTGTGCTTTC TGTGTTAAAT GTCTTCTGGG GAGGCCCAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046974|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0728--SH3 domain
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR028320--iASPP
IPR001452--SH3_domain
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3
Pfam

PF12796--Ank_2
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00248--ANK
SM00326--SH3
Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045296--F:cadherin binding
GO:0042802--F:identical protein binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0006915--P:apoptotic process
GO:0060048--P:cardiac muscle contraction
GO:0003215--P:cardiac right ventricle morphogenesis
GO:0031076--P:embryonic camera-type eye development
GO:0042633--P:hair cycle
GO:0035264--P:multicellular organism growth
GO:0048871--P:multicellular organismal homeostasis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045597--P:positive regulation of cell differentiation
GO:0009791--P:post-embryonic development
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006351--P:transcription, DNA-templated
GO:0003229--P:ventricular cardiac muscle tissue development
KEGG hsa:10848
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001236 Ailuropoda melanoleuca 90.31 8.00e-179 620.00
IUUC-Aca-004907 Anolis carolinensis 79.70 5.00e-99 355.00
IUUC-Bta-012555 Bos taurus 86.23 0.00e+00 1050.00
IUUC-Cfa-020223 Canis familiaris 90.00 3.00e-174 605.00
IUUC-Cpo-022180 Cavia porcellus 77.44 0.00e+00 1064.00
IUUC-Csa-023984 Chlorocebus sabaeus 98.27 8.00e-167 580.00
IUUC-Dre-027600 Danio rerio 48.17 2.00e-91 330.00
IUUC-Dno-029486 Dasypus novemcinctus 86.94 0.00e+00 724.00
IUUC-Dor-030334 Dipodomys ordii 87.78 2.00e-152 533.00
IUUC-Eca-033590 Equus caballus 85.31 0.00e+00 662.00
IUUC-Gac-041648 Gasterosteus aculeatus 51.46 4.00e-96 345.00
IUUC-Itr-048093 Ictidomys tridecemlineatus 85.10 0.00e+00 1028.00
IUUC-Lch-049426 Latimeria chalumnae 55.52 7.00e-95 342.00
IUUC-Laf-054593 Loxodonta africana 88.43 0.00e+00 1061.00
IUUC-Mcc-055896 Macaca mulatta 96.87 0.00e+00 1192.00
IUUC-Mmr-061007 Microcebus murinus 82.20 0.00e+00 976.00
IUUC-Mmu-063188 Mus musculus 88.41 0.00e+00 1134.00
IUUC-Mac-065548 Musa acuminata 34.52 2.00e-05 44.30
IUUC-Mpu-066381 Mustela putorius furo 90.50 4.00e-174 605.00
IUUC-Nle-069627 Nomascus leucogenys 99.72 2.00e-174 605.00
IUUC-Ont-071459 Oreochromis niloticus 49.18 9.00e-92 331.00
IUUC-Ocu-074924 Oryctolagus cuniculus 74.86 4.00e-119 421.00
IUUC-Obr-076350 Oryza brachyantha 32.97 1.40e-02 34.30
IUUC-Olo-080981 Oryza longistaminata 32.97 2.00e-02 33.90
IUUC-Ola-087294 Oryzias latipes 50.45 3.00e-94 340.00
IUUC-Oga-088356 Otolemur garnettii 90.40 0.00e+00 1113.00
IUUC-Oar-089777 Ovis aries 92.57 4.00e-156 545.00
IUUC-Ptr-090843 Pan troglodytes 99.64 0.00e+00 1217.00
IUUC-Pfo-096934 Poecilia formosa 50.00 3.00e-96 346.00
IUUC-Pab-098564 Pongo abelii 99.16 5.00e-174 603.00
IUUC-Pca-100382 Procavia capensis 81.64 0.00e+00 861.00
IUUC-Pva-102159 Pteropus vampyrus 91.76 4.00e-163 568.00
IUUC-Rno-106055 Rattus norvegicus 87.73 0.00e+00 1120.00
IUUC-Tru-117623 Takifugu rubripes 51.58 3.00e-95 343.00
IUUC-Tni-120255 Tetraodon nigroviridis 54.00 4.00e-94 338.00
IUUC-Xtr-132435 Xenopus tropicalis 70.80 1.00e-90 327.00
Created Date 25-Jun-2017

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