iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/UBZ	1.10e-06	29.2	149	175

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm....vdqtdfeeHlDeCl 24
           l CP+Cqk+    ++q d+++Hl++Cl
   Q: 149  LNCPLCQKAfdpkLTQLDVDSHLAQCL 175
           89************************8 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity).

Protein Sequence
(Fasta)

MEEERRLRGR LSRRRPPAGG GPPNCRPWFL SEESKSEPWA ALLRSTVGGN TDWTPNSQPL 60
PPLPAFPSQE SLPDPESTVP PEVFTVGSKT FSWTPFPPAL RGSGSSCRLL RCPEGSPGSP 120

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Nucleotide Sequence
(Fasta)

GTCGCGACTC TCCCTCAAGG CGGCAGCCTC GTGTTCCCAA CGGTTGGGAT CTCGGCGCCT 60
TAGATTTCCA GCGCCACAAA AGGGAGCTGG CACTTGGCAG AGCGGAGAGC GGGGGCTCTG 120

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Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031491--FANCA_interact
IPR031490--UBZ_FAAP20

Pfam

PF15751--FANCA_interact
PF15750--UBZ_FAAP20

Gene Ontology

GO:0005694--C:chromosome
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0036297--P:interstrand cross-link repair
GO:0019985--P:translesion synthesis

KEGG

rno:362678

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002409	Ailuropoda melanoleuca	63.33	8.00e-06	41.20
IUUC-Bta-013416	Bos taurus	41.14	2.00e-17	81.60
IUUC-Cja-019117	Callithrix jacchus	49.10	2.00e-28	119.00
IUUC-Cpo-021546	Cavia porcellus	64.81	5.00e-13	65.10
IUUC-Csa-024066	Chlorocebus sabaeus	52.83	6.00e-31	126.00
IUUC-Dno-029273	Dasypus novemcinctus	60.78	2.00e-11	60.50
IUUC-Ete-033066	Echinops telfairi	41.57	4.00e-24	103.00
IUUC-Eca-033947	Equus caballus	54.26	6.00e-25	107.00
IUUC-Eeu-034567	Erinaceus europaeus	50.67	3.00e-24	103.00
IUUC-Gac-041654	Gasterosteus aculeatus	51.35	1.00e-06	45.80
IUUC-Ggo-045315	Gorilla gorilla	51.85	3.00e-30	125.00
IUUC-Hsa-046575	Homo sapiens	51.53	2.00e-31	128.00
IUUC-Itr-048140	Ictidomys tridecemlineatus	55.97	7.00e-24	103.00
IUUC-Laf-054078	Loxodonta africana	45.93	2.00e-25	108.00
IUUC-Mmr-060675	Microcebus murinus	53.42	1.00e-27	115.00
IUUC-Mmu-063902	Mus musculus	85.28	1.00e-71	262.00
IUUC-Nle-069135	Nomascus leucogenys	52.76	4.00e-33	134.00
IUUC-Oga-088370	Otolemur garnettii	54.71	2.00e-35	141.00
IUUC-Oar-090037	Ovis aries	46.43	3.00e-13	69.30
IUUC-Ptr-091600	Pan troglodytes	52.41	4.00e-31	127.00
IUUC-Pan-091731	Papio anubis	52.73	2.00e-32	132.00
IUUC-Pfo-096538	Poecilia formosa	44.74	4.00e-06	43.90
IUUC-Pab-098384	Pongo abelii	51.23	2.00e-30	126.00
IUUC-Pca-100684	Procavia capensis	44.51	3.00e-27	114.00
IUUC-Sha-107222	Sarcophilus harrisii	59.52	2.00e-12	64.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence