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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063854
UUCD1 version UUC-MuM-01017
Ensembl Protein ID ENSMUSP00000027357.5
UniProt Accession Q9QZR0; Q3TAL8; Q9DCW7; RNF25_MOUSE
Genbank Protein ID AAD48057.1; BAB22071.1; BAE42650.1; AAH22715.1; AAH48821.1
Protein Name E3 ubiquitin-protein ligase RNF25; RING finger protein 25; RING finger protein AO7; RING-type E3 ubiquitin transferase RNF25
Genbank Nucleotide ID AF171060; AK002399; AK171752; BC022715; BC048821
Gene Name Rnf25
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026171.12 ENSMUST00000135140.7 ENSMUSP00000138040.1
ENSMUSG00000026171.12 ENSMUST00000027357.11 ENSMUSP00000027357.5
ENSMUSG00000026171.12 ENSMUST00000113721.7 ENSMUSP00000109350.1
ENSMUSG00000026171.12 ENSMUST00000136078.1 ENSMUSP00000117692.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 3.90e-06 28.4 134 199
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkw...........pglknssskefr.................CPlCr 46
           C iCl+ f  k+    +pC H fh +Cl ++                      +                 CP+Cr
   Q: 134  CVICLYGFqeKEAFTKTPCYHYFHCHCLARYiqhmeqelttqE----------QeqerqhvvtkqkavgvqCPVCR 199
           ********65333556************999755554444330..........244555666666667777****8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B (By similarity).
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B (By similarity).
Protein Sequence
(Fasta)
MAASASTAAG EEDWVLPSEV EVLESIYLDE LQVMKGNGRS PWEIFITLHP ATAEVQDSQF 60
VCFTLVLRIP VQYPHEVPQI SIRNPRGLSD EQIHKISQAL GHVAKEGLGT AMLYELIEKG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063854|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTTCCGGTT CCGGCCAAGA GCCGGAGAAG ACATGGCGGC GTCTGCGTCG ACAGCTGCTG 60
GGGAAGAGGA CTGGTAACTT TGGGTCATAG GTTTTGGCTG GCTGCCTGGA TCTGGTGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063854|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50908--RWD
PS50089--ZF_RING_2
Pfam

PF05773--RWD
SMART

SM00184--RING
SM00591--RWD
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0051059--F:NF-kappaB binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0016567--P:protein ubiquitination
KEGG mmu:57751
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001954 Ailuropoda melanoleuca 80.17 0.00e+00 640.00
IUUC-Atr-002830 Amborella trichopoda 24.02 6.00e-15 75.10
IUUC-Apl-003293 Anas platyrhynchos 68.77 6.00e-94 337.00
IUUC-Aca-005092 Anolis carolinensis 48.43 1.00e-110 393.00
IUUC-Aly-005434 Arabidopsis lyrata 28.05 5.00e-19 88.20
IUUC-Ath-006770 Arabidopsis thaliana 28.40 2.00e-17 83.20
IUUC-Ame-011754 Astyanax mexicanus 49.62 1.00e-57 217.00
IUUC-Bta-012592 Bos taurus 77.07 0.00e+00 641.00
IUUC-Bdi-015061 Brachypodium distachyon 25.00 1.00e-15 77.40
IUUC-Bol-015743 Brassica oleracea 29.91 2.00e-17 83.20
IUUC-Bra-018072 Brassica rapa 28.51 1.00e-14 74.30
IUUC-Cel-018515 Caenorhabditis elegans 25.76 2.00e-06 46.20
IUUC-Cja-018930 Callithrix jacchus 83.15 0.00e+00 702.00
IUUC-Cfa-020156 Canis familiaris 80.39 0.00e+00 675.00
IUUC-Cpo-021290 Cavia porcellus 77.16 0.00e+00 671.00
IUUC-Csa-023214 Chlorocebus sabaeus 82.57 0.00e+00 694.00
IUUC-Cin-025416 Ciona intestinalis 34.24 1.00e-41 164.00
IUUC-Csv-026360 Ciona savignyi 34.08 1.00e-43 171.00
IUUC-Dre-028670 Danio rerio 49.25 2.00e-55 209.00
IUUC-Dno-029970 Dasypus novemcinctus 78.65 0.00e+00 681.00
IUUC-Dor-030152 Dipodomys ordii 79.69 0.00e+00 649.00
IUUC-Dme-031914 Drosophila melanogaster 34.57 3.00e-37 149.00
IUUC-Ete-033105 Echinops telfairi 69.72 4.00e-142 498.00
IUUC-Eca-033800 Equus caballus 79.74 0.00e+00 634.00
IUUC-Eeu-034525 Erinaceus europaeus 60.04 2.00e-111 395.00
IUUC-Fca-035644 Felis catus 81.84 0.00e+00 715.00
IUUC-Fal-037121 Ficedula albicollis 50.80 7.00e-110 390.00
IUUC-Gmo-039444 Gadus morhua 50.40 2.00e-57 216.00
IUUC-Gga-041221 Gallus gallus 44.25 2.00e-75 276.00
IUUC-Gac-042354 Gasterosteus aculeatus 47.83 8.00e-68 251.00
IUUC-Gma-043721 Glycine max 28.25 1.00e-14 74.30
IUUC-Ggo-044879 Gorilla gorilla 82.57 0.00e+00 702.00
IUUC-Hsa-045739 Homo sapiens 82.35 0.00e+00 701.00
IUUC-Itr-047915 Ictidomys tridecemlineatus 84.53 0.00e+00 677.00
IUUC-Lch-050277 Latimeria chalumnae 58.90 2.00e-66 246.00
IUUC-Lpe-051139 Leersia perrieri 28.57 5.00e-18 85.10
IUUC-Loc-052367 Lepisosteus oculatus 56.96 2.00e-19 86.30
IUUC-Laf-053559 Loxodonta africana 75.27 0.00e+00 682.00
IUUC-Mcc-055367 Macaca mulatta 74.73 0.00e+00 639.00
IUUC-Meu-056730 Macropus eugenii 66.14 7.00e-134 470.00
IUUC-Mtr-058418 Medicago truncatula 26.18 5.00e-15 75.50
IUUC-Mga-060090 Meleagris gallopavo 68.75 2.00e-63 236.00
IUUC-Mmr-060618 Microcebus murinus 83.44 0.00e+00 713.00
IUUC-Mdo-063084 Monodelphis domestica 67.18 8.00e-145 506.00
IUUC-Mac-064922 Musa acuminata 27.82 2.00e-17 82.80
IUUC-Mpu-066419 Mustela putorius furo 79.30 0.00e+00 650.00
IUUC-Mlu-067289 Myotis lucifugus 76.96 0.00e+00 648.00
IUUC-Nle-069090 Nomascus leucogenys 83.01 0.00e+00 726.00
IUUC-Opr-070601 Ochotona princeps 77.46 2.00e-180 625.00
IUUC-Ont-072434 Oreochromis niloticus 51.36 1.00e-66 246.00
IUUC-Ocu-074855 Oryctolagus cuniculus 79.65 0.00e+00 667.00
IUUC-Oba-075792 Oryza barthii 27.02 2.00e-17 83.20
IUUC-Obr-076917 Oryza brachyantha 26.01 2.00e-17 83.20
IUUC-Ogl-077872 Oryza glaberrima 25.26 4.00e-15 75.90
IUUC-Ogu-078151 Oryza glumaepatula 25.42 2.00e-16 80.10
IUUC-Oin-079465 Oryza indica 25.78 8.00e-17 81.30
IUUC-Olo-080907 Oryza longistaminata 26.32 5.00e-13 69.70
IUUC-Ome-081752 Oryza meridionalis 25.26 5.00e-16 79.00
IUUC-Oni-082420 Oryza nivara 26.46 2.00e-16 80.50
IUUC-Opu-083810 Oryza punctata 27.68 1.00e-17 84.30
IUUC-Oru-085177 Oryza rufipogon 26.33 2.00e-17 83.20
IUUC-Ola-087231 Oryzias latipes 50.72 2.00e-49 188.00
IUUC-Oga-088963 Otolemur garnettii 83.44 0.00e+00 722.00
IUUC-Oar-089292 Ovis aries 77.17 0.00e+00 691.00
IUUC-Ptr-091214 Pan troglodytes 83.01 0.00e+00 707.00
IUUC-Pan-092823 Papio anubis 82.79 0.00e+00 749.00
IUUC-Psi-094084 Pelodiscus sinensis 39.02 1.00e-43 170.00
IUUC-Pfo-096406 Poecilia formosa 48.25 9.00e-61 227.00
IUUC-Pab-098212 Pongo abelii 83.44 0.00e+00 712.00
IUUC-Pop-099369 Populus trichocarpa 25.51 2.00e-15 76.60
IUUC-Pca-100897 Procavia capensis 70.81 4.00e-168 584.00
IUUC-Ppe-101702 Prunus persica 24.51 3.00e-14 72.80
IUUC-Pva-102899 Pteropus vampyrus 78.43 0.00e+00 654.00
IUUC-Rno-105369 Rattus norvegicus 94.96 0.00e+00 842.00
IUUC-Sha-107344 Sarcophilus harrisii 66.14 7.00e-136 477.00
IUUC-Smo-109636 Selaginella moellendorffii 25.33 2.00e-09 55.10
IUUC-Sit-109795 Setaria italica 26.38 6.00e-19 88.20
IUUC-Sly-111014 Solanum lycopersicum 25.16 6.00e-17 83.20
IUUC-Stu-112139 Solanum tuberosum 25.93 7.00e-19 87.80
IUUC-Sar-113487 Sorex araneus 85.71 1.00e-49 191.00
IUUC-Sbi-114714 Sorghum bicolor 26.80 1.00e-17 83.60
IUUC-Ssc-115465 Sus scrofa 75.82 0.00e+00 676.00
IUUC-Tgu-117113 Taeniopygia guttata 72.17 2.00e-95 342.00
IUUC-Tsy-119186 Tarsius syrichta 70.83 1.00e-52 200.00
IUUC-Tni-120219 Tetraodon nigroviridis 51.70 1.00e-35 141.00
IUUC-Tca-121748 Theobroma cacao 27.38 6.00e-14 71.60
IUUC-Tae-123014 Triticum aestivum 27.76 7.00e-15 74.70
IUUC-Tbe-127584 Tupaia belangeri 70.50 3.00e-113 401.00
IUUC-Ttr-128244 Tursiops truncatus 78.65 0.00e+00 643.00
IUUC-Vpa-130354 Vicugna pacos 79.33 0.00e+00 671.00
IUUC-Xtr-132402 Xenopus tropicalis 52.16 2.00e-70 259.00
IUUC-Xma-133442 Xiphophorus maculatus 46.43 3.00e-61 229.00
Created Date 25-Jun-2017

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