iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0261931	FBtr0332963	FBpp0305179
FBgn0261931	FBtr0303708	FBpp0292725
FBgn0261931	FBtr0303709	FBpp0292726
FBgn0261931	FBtr0303710	FBpp0292727

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.30e-116	387.0	1091	1425

Active Site

Position(s)	Description	Evidence
1394	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlk.krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfy 97
           +dl+  rl v +  Eegld+gG++ref++lls+el+np++glf+ys+nd++t+q++p s +   +  ++F+f Gr+lg+al+++ lld++++++fy
   Q: 1091 KDLQrGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFV-DNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFY 1185
           444416999**************************************************985.5******************************** PP
   S: 98   klllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveaf 193
           k ll+ ++ l+dle++d+e+++sl++i++n+    +  +l ltf+v+ee+lg++ ++eLkpgG+ni ++++Nk+eY ++++++rl++g++eq+e++
   Q: 1186 KALLRLPVALSDLESLDNEFHQSLQWIRDND--IGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESL 1279
           ****************************994..3466789******************************************************** PP
   S: 194  reGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....pr 285
            +Gf+evi+ +l+s+F+++elel+i G++eid +d++ +t+y++gy++++++i wFw+v+e+fs+e+r ++LqFvTg+s++P +Gf +l+    pr
   Q: 1280 VRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRgstgPR 1375
           ************************************************************************************************ PP
   S: 286  lfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +f+i+k+++++ lP+++TCfn+L+LP+Y++ e l+ekLl+A+eet+ F+ 
   Q: 1376 RFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGI 1425
           **********************************************9986 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MEPPAAPVPL QPLAASSACL ADRSPVDPIA VRLQQEEQAE GDDEEEEEEE EDDDDDPKEE 60
EAFYEARNGN ESDELEQAFQ SALTLTNDVH VSVSEVEEHE PPLASRNQEV AEVEEQQQQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATTGACAT CTGGTCACAT TGCACTAGAC CCGAAATATA TATTTTATTT AGCTTTTGCA 60
ATATCCTTAA ATTAACAATT GATCAACTAA AGCCACGGCC TTGCGGGCAG TGAGCACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	71.91	0.00e+00	755.00
IUUC-Apl-003935	Anas platyrhynchos	71.54	0.00e+00	751.00
IUUC-Aca-004558	Anolis carolinensis	71.71	0.00e+00	752.00
IUUC-Ame-010893	Astyanax mexicanus	70.88	0.00e+00	745.00
IUUC-Bta-013093	Bos taurus	71.91	0.00e+00	752.00
IUUC-Cel-018137	Caenorhabditis elegans	38.11	5.00e-93	335.00
IUUC-Cja-019651	Callithrix jacchus	71.91	0.00e+00	754.00
IUUC-Cfa-021232	Canis familiaris	71.91	0.00e+00	750.00
IUUC-Cpo-021770	Cavia porcellus	71.91	0.00e+00	753.00
IUUC-Csa-023970	Chlorocebus sabaeus	71.91	0.00e+00	756.00
IUUC-Cho-024740	Choloepus hoffmanni	64.47	0.00e+00	640.00
IUUC-Csv-026127	Ciona savignyi	65.18	7.00e-138	482.00
IUUC-Dre-028275	Danio rerio	70.88	0.00e+00	745.00
IUUC-Dno-029963	Dasypus novemcinctus	71.31	0.00e+00	742.00
IUUC-Dor-031030	Dipodomys ordii	70.50	1.00e-162	566.00
IUUC-Ete-032352	Echinops telfairi	69.03	0.00e+00	687.00
IUUC-Eca-033978	Equus caballus	71.91	0.00e+00	754.00
IUUC-Eeu-035278	Erinaceus europaeus	75.70	9.00e-167	580.00
IUUC-Fca-036157	Felis catus	71.51	0.00e+00	742.00
IUUC-Fal-037110	Ficedula albicollis	71.91	0.00e+00	753.00
IUUC-Gmo-039291	Gadus morhua	61.17	2.00e-166	579.00
IUUC-Gga-040821	Gallus gallus	71.91	0.00e+00	756.00
IUUC-Gac-042181	Gasterosteus aculeatus	70.88	0.00e+00	745.00
IUUC-Ggo-044862	Gorilla gorilla	71.91	0.00e+00	754.00
IUUC-Hsa-046219	Homo sapiens	71.91	0.00e+00	756.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	67.86	0.00e+00	698.00
IUUC-Lch-050526	Latimeria chalumnae	70.78	0.00e+00	749.00
IUUC-Loc-052648	Lepisosteus oculatus	70.92	0.00e+00	750.00
IUUC-Laf-054005	Loxodonta africana	71.91	0.00e+00	755.00
IUUC-Mcc-055314	Macaca mulatta	71.91	0.00e+00	756.00
IUUC-Meu-056751	Macropus eugenii	71.80	7.00e-167	581.00
IUUC-Mga-059545	Meleagris gallopavo	67.66	0.00e+00	703.00
IUUC-Mmr-061526	Microcebus murinus	71.91	0.00e+00	754.00
IUUC-Mdo-063017	Monodelphis domestica	70.92	0.00e+00	743.00
IUUC-Mmu-064165	Mus musculus	72.11	0.00e+00	756.00
IUUC-Mpu-065835	Mustela putorius furo	71.06	0.00e+00	742.00
IUUC-Mlu-067709	Myotis lucifugus	70.52	0.00e+00	728.00
IUUC-Nle-069308	Nomascus leucogenys	71.91	0.00e+00	756.00
IUUC-Opr-070208	Ochotona princeps	66.27	0.00e+00	677.00
IUUC-Ont-071345	Oreochromis niloticus	70.08	0.00e+00	737.00
IUUC-Oan-072807	Ornithorhynchus anatinus	68.46	0.00e+00	719.00
IUUC-Ocu-074775	Oryctolagus cuniculus	71.91	0.00e+00	756.00
IUUC-Ola-087225	Oryzias latipes	70.94	0.00e+00	727.00
IUUC-Oga-088177	Otolemur garnettii	71.91	0.00e+00	756.00
IUUC-Oar-089452	Ovis aries	71.91	0.00e+00	755.00
IUUC-Ptr-090806	Pan troglodytes	71.91	0.00e+00	756.00
IUUC-Pan-091838	Papio anubis	71.77	0.00e+00	749.00
IUUC-Psi-094090	Pelodiscus sinensis	70.30	0.00e+00	736.00
IUUC-Pfo-096520	Poecilia formosa	70.26	0.00e+00	740.00
IUUC-Pab-098405	Pongo abelii	71.91	0.00e+00	756.00
IUUC-Pca-100129	Procavia capensis	60.39	1.00e-153	537.00
IUUC-Pva-102324	Pteropus vampyrus	71.91	0.00e+00	755.00
IUUC-Rno-105943	Rattus norvegicus	72.11	0.00e+00	758.00
IUUC-Sha-106748	Sarcophilus harrisii	68.89	0.00e+00	710.00
IUUC-Sar-113505	Sorex araneus	71.91	0.00e+00	750.00
IUUC-Ssc-115534	Sus scrofa	72.25	5.00e-155	539.00
IUUC-Tgu-117078	Taeniopygia guttata	71.49	0.00e+00	749.00
IUUC-Tru-118671	Takifugu rubripes	71.00	0.00e+00	749.00
IUUC-Tsy-119379	Tarsius syrichta	66.11	2.00e-138	486.00
IUUC-Tni-120619	Tetraodon nigroviridis	70.48	0.00e+00	729.00
IUUC-Tbe-127762	Tupaia belangeri	68.22	0.00e+00	687.00
IUUC-Ttr-128806	Tursiops truncatus	66.67	0.00e+00	688.00
IUUC-Vpa-130498	Vicugna pacos	57.87	1.00e-151	530.00
IUUC-Xtr-132903	Xenopus tropicalis	68.53	0.00e+00	709.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence