iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069913

Ensembl Protein ID

ENSNLEP00000001073.2

UniProt Accession

G1QJH9; G1QJH9_NOMLE

Genbank Protein ID

ENSNLEP00000001073

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01012678

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000000910.2	ENSNLET00000001137.2	ENSNLEP00000001073.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/CARD	97.57	0.00e+00	1557.00	IUUC-Hsa-046093

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGKLHSKPAA VCKRRESPEG DSFAVSAAWA RKGIEEWIGR QRCPGGVSGP RQLRLAGTIG 60
RSTRELVGDV LRDTLSEEEE DDFRLEVALP PEKTDGLGSG DEKKMERVSE PCPGSKKQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGAGCGC GTCCCGGCGC CGCCTCGGGC TCCGCTCGGC TCGGGGGCTG CTCCGGGAGG 60
AGGAGAGCCA GGGGAGGCGC CAGGCCTGCG GGCCGGGCGC ATGGCTTAGG GACGCTCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS51450--LRR
PS50837--NACHT

Pfam

PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	81.69	0.00e+00	1249.00
IUUC-Ame-011021	Astyanax mexicanus	48.04	0.00e+00	778.00
IUUC-Bta-013241	Bos taurus	81.92	0.00e+00	1374.00
IUUC-Cja-019633	Callithrix jacchus	90.39	0.00e+00	1077.00
IUUC-Cfa-020039	Canis familiaris	83.55	0.00e+00	1393.00
IUUC-Cpo-022337	Cavia porcellus	80.43	0.00e+00	1318.00
IUUC-Csa-023906	Chlorocebus sabaeus	95.48	0.00e+00	1581.00
IUUC-Dre-027568	Danio rerio	50.00	0.00e+00	751.00
IUUC-Dno-029098	Dasypus novemcinctus	81.37	0.00e+00	1295.00
IUUC-Dor-031102	Dipodomys ordii	83.42	0.00e+00	627.00
IUUC-Ete-032943	Echinops telfairi	77.43	0.00e+00	1127.00
IUUC-Eca-034310	Equus caballus	85.17	0.00e+00	1418.00
IUUC-Eeu-034589	Erinaceus europaeus	83.48	1.00e-164	574.00
IUUC-Fca-036252	Felis catus	86.76	0.00e+00	649.00
IUUC-Gac-041442	Gasterosteus aculeatus	49.02	0.00e+00	747.00
IUUC-Ggo-044861	Gorilla gorilla	97.91	0.00e+00	1562.00
IUUC-Hsa-046093	Homo sapiens	97.57	0.00e+00	1556.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	81.33	0.00e+00	1241.00
IUUC-Lch-049454	Latimeria chalumnae	53.88	0.00e+00	920.00
IUUC-Laf-053553	Loxodonta africana	83.78	0.00e+00	1278.00
IUUC-Mcc-055772	Macaca mulatta	95.37	0.00e+00	1549.00
IUUC-Meu-056785	Macropus eugenii	69.04	6.00e-115	408.00
IUUC-Mmr-060596	Microcebus murinus	84.47	0.00e+00	1362.00
IUUC-Mdo-062983	Monodelphis domestica	67.67	0.00e+00	1117.00
IUUC-Mmu-063951	Mus musculus	77.74	0.00e+00	1281.00
IUUC-Mpu-066412	Mustela putorius furo	82.85	0.00e+00	1378.00
IUUC-Mlu-067601	Myotis lucifugus	81.11	0.00e+00	1269.00
IUUC-Opr-070999	Ochotona princeps	84.74	0.00e+00	997.00
IUUC-Ont-072512	Oreochromis niloticus	48.91	0.00e+00	805.00
IUUC-Oan-073564	Ornithorhynchus anatinus	63.57	0.00e+00	970.00
IUUC-Ocu-074837	Oryctolagus cuniculus	86.33	0.00e+00	1383.00
IUUC-Ola-086555	Oryzias latipes	48.52	0.00e+00	737.00
IUUC-Oga-088909	Otolemur garnettii	84.59	0.00e+00	1372.00
IUUC-Oar-089315	Ovis aries	81.46	0.00e+00	1321.00
IUUC-Ptr-090542	Pan troglodytes	98.03	0.00e+00	1564.00
IUUC-Pan-092545	Papio anubis	95.48	0.00e+00	1546.00
IUUC-Pma-094167	Petromyzon marinus	33.96	1.00e-64	240.00
IUUC-Ppa-095344	Physcomitrella patens	32.63	1.00e-06	48.90
IUUC-Pfo-096976	Poecilia formosa	46.77	0.00e+00	755.00
IUUC-Pab-098481	Pongo abelii	97.45	0.00e+00	1552.00
IUUC-Pca-100135	Procavia capensis	79.85	0.00e+00	1140.00
IUUC-Pva-102127	Pteropus vampyrus	83.84	0.00e+00	1269.00
IUUC-Rno-105783	Rattus norvegicus	80.71	0.00e+00	1278.00
IUUC-Sce-106163	Saccharomyces cerevisiae	25.96	8.00e-03	37.00
IUUC-Sar-113448	Sorex araneus	75.05	0.00e+00	686.00
IUUC-Tru-118708	Takifugu rubripes	46.55	0.00e+00	703.00
IUUC-Tni-120172	Tetraodon nigroviridis	37.75	1.00e-33	137.00
IUUC-Tbe-127661	Tupaia belangeri	86.77	0.00e+00	855.00
IUUC-Ttr-128318	Tursiops truncatus	77.52	0.00e+00	1167.00
IUUC-Vpa-130502	Vicugna pacos	76.04	2.00e-88	320.00
IUUC-Xma-133151	Xiphophorus maculatus	46.43	0.00e+00	756.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence