iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023641

Ensembl Protein ID

ENSCSAP00000005021.1

UniProt Accession

A0A0D9R8T2; A0A0D9R8T2_CHLSB

Genbank Protein ID

ENSCSAP00000005021

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01115367

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000008778.1	ENSCSAT00000006827.1	ENSCSAP00000005021.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.70e-12	45.9	345	373
ULD/UDP/UBQ/UBQ_Other	2.50e-12	46.5	231	287

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           ++ W C++CTf+N+P++++CemCs++R+c
   Q: 345  QPSWPCPSCTFINAPSRPGCEMCSTQRPC 373
           578*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 9    dgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
           ++s +  l+v+p++tVa L+e+++++lg+pp+ qr+++ G++L  + ++La+yg++++
   Q: 231  TSSaHVALQVHPHCTVAALQEQVFSELGFPPAVQRWVI-GRCLcVPERSLASYGVRQD 287
           3333555669****************************.**************99754 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MAPPAGGAAA ASDLGSAAVL LTVHVAVRLL GAGPDAEAQL RRLQLSADPE RPGRFRLELL 60
DAGPGAVNLE WPLESVSYTI RGPTQHELQP PPGGPGTLSL HFLNPQEAQR WAVLVRGATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGC CAGCGGGCGG GGCGGCGGCG GCCTCGGACT TGGGCTCGGC CGCAGTGCTC 60
TTGACTGTGC ACGTCGCTGT GAGGCTGCTG GGCGCCGGGC CAGACGCCGA GGCACAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	36.84	2.60e-02	32.70
IUUC-Aml-001223	Ailuropoda melanoleuca	77.81	8.00e-127	446.00
IUUC-Apl-004151	Anas platyrhynchos	68.09	1.00e-17	80.90
IUUC-Ang-009713	Aspergillus niger	32.79	2.10e-02	33.50
IUUC-Bta-012948	Bos taurus	80.64	1.00e-136	479.00
IUUC-Cel-018155	Caenorhabditis elegans	36.54	6.40e-02	29.30
IUUC-Cja-019031	Callithrix jacchus	88.64	3.00e-140	491.00
IUUC-Cfa-020863	Canis familiaris	71.27	9.00e-105	373.00
IUUC-Cpo-022499	Cavia porcellus	73.67	5.00e-125	441.00
IUUC-Dno-029459	Dasypus novemcinctus	58.87	3.00e-57	215.00
IUUC-Dor-030914	Dipodomys ordii	65.08	6.00e-84	304.00
IUUC-Ete-032940	Echinops telfairi	69.45	9.00e-98	350.00
IUUC-Eca-033537	Equus caballus	79.27	1.00e-132	465.00
IUUC-Eeu-035176	Erinaceus europaeus	70.41	6.00e-62	231.00
IUUC-Fca-035971	Felis catus	75.81	1.00e-116	412.00
IUUC-Gmo-039219	Gadus morhua	38.46	1.00e-48	187.00
IUUC-Gac-041562	Gasterosteus aculeatus	55.56	3.00e-29	122.00
IUUC-Ggo-044678	Gorilla gorilla	89.89	7.00e-148	516.00
IUUC-Hsa-046578	Homo sapiens	93.07	2.00e-154	538.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	73.42	4.00e-131	461.00
IUUC-Mcc-055686	Macaca mulatta	87.57	1.00e-154	538.00
IUUC-Meu-055912	Macropus eugenii	53.18	7.00e-59	220.00
IUUC-Mmr-060584	Microcebus murinus	79.73	2.00e-141	495.00
IUUC-Mdo-062191	Monodelphis domestica	55.95	2.00e-78	286.00
IUUC-Mmu-063740	Mus musculus	70.44	4.00e-110	391.00
IUUC-Mpu-066878	Mustela putorius furo	73.46	1.00e-106	379.00
IUUC-Mlu-067878	Myotis lucifugus	78.98	1.00e-132	465.00
IUUC-Nle-069748	Nomascus leucogenys	92.38	3.00e-138	484.00
IUUC-Ont-072270	Oreochromis niloticus	39.24	4.00e-49	188.00
IUUC-Oga-088300	Otolemur garnettii	80.21	2.00e-143	501.00
IUUC-Oar-089549	Ovis aries	79.05	6.00e-133	467.00
IUUC-Ptr-090961	Pan troglodytes	92.36	1.00e-138	486.00
IUUC-Pan-092687	Papio anubis	97.51	5.00e-162	563.00
IUUC-Pfo-096865	Poecilia formosa	33.66	1.00e-37	150.00
IUUC-Pab-097872	Pongo abelii	89.16	1.00e-137	483.00
IUUC-Pca-100363	Procavia capensis	71.98	1.00e-64	239.00
IUUC-Pva-102595	Pteropus vampyrus	76.01	1.00e-114	406.00
IUUC-Rno-105856	Rattus norvegicus	71.39	4.00e-109	387.00
IUUC-Sha-106838	Sarcophilus harrisii	53.60	1.00e-66	246.00
IUUC-Sar-113611	Sorex araneus	71.58	3.00e-27	115.00
IUUC-Ssc-116263	Sus scrofa	76.22	7.00e-133	466.00
IUUC-Tru-118089	Takifugu rubripes	42.23	1.00e-56	213.00
IUUC-Tni-120004	Tetraodon nigroviridis	40.58	2.00e-45	176.00
IUUC-Tbe-127471	Tupaia belangeri	73.02	4.00e-106	377.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence