iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020315

Ensembl Protein ID

ENSCAFP00000029334.3

UniProt Accession

F1P6T3; F1P6T3_CANLF

Genbank Protein ID

ENSCAFP00000029334

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03006776

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000019810.3	ENSCAFT00000031512.3	ENSCAFP00000029334.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.80e-18	65.5	601	652

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 601  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--EANGRIGWFPSTYVEE 652
           67**********************************..9*************86 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MKMGMSEDDK RNCCLLEIQE TEAKYYRTLE DIEKNYMTPL RLVLSPADMA AIFINLEDLI 60
KVHHSFLRAI DVSMMAGGST LAKVFLDFKE RLLIYGEYCS HMEHAQNTLN QLLASREDFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAAGCC CCCTACCCCG CAGCGCTGCC CCTGCACCGA AGGCTCTGAG CCACTGTGGG 60
TAGGGTGGCT CCCTGGGACA GAGAGCTGCA GAGGCTGCAC CCCAGTCCCC CTTCTTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	92.31	0.00e+00	1223.00
IUUC-Apl-003262	Anas platyrhynchos	86.13	0.00e+00	1188.00
IUUC-Aca-004628	Anolis carolinensis	64.39	0.00e+00	803.00
IUUC-Ath-007352	Arabidopsis thaliana	39.22	1.00e-03	38.10
IUUC-Ame-011608	Astyanax mexicanus	80.54	0.00e+00	1130.00
IUUC-Bta-013147	Bos taurus	91.69	0.00e+00	1270.00
IUUC-Cel-018578	Caenorhabditis elegans	28.28	2.00e-73	270.00
IUUC-Cja-018877	Callithrix jacchus	86.67	0.00e+00	1150.00
IUUC-Cpo-021543	Cavia porcellus	89.68	0.00e+00	1215.00
IUUC-Csa-024204	Chlorocebus sabaeus	88.26	0.00e+00	1218.00
IUUC-Dre-028308	Danio rerio	76.59	0.00e+00	1083.00
IUUC-Dno-029584	Dasypus novemcinctus	92.83	0.00e+00	1176.00
IUUC-Dor-031014	Dipodomys ordii	80.68	0.00e+00	1032.00
IUUC-Eca-033448	Equus caballus	88.39	0.00e+00	1203.00
IUUC-Eeu-035182	Erinaceus europaeus	87.08	2.00e-135	476.00
IUUC-Fca-035460	Felis catus	92.54	0.00e+00	1279.00
IUUC-Fal-036684	Ficedula albicollis	84.64	0.00e+00	1181.00
IUUC-Gmo-038816	Gadus morhua	79.21	0.00e+00	1067.00
IUUC-Gga-040999	Gallus gallus	90.24	0.00e+00	1211.00
IUUC-Gac-041353	Gasterosteus aculeatus	80.42	0.00e+00	1095.00
IUUC-Ggo-044558	Gorilla gorilla	90.57	0.00e+00	1227.00
IUUC-Hsa-046208	Homo sapiens	90.57	0.00e+00	1227.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	87.44	0.00e+00	1193.00
IUUC-Loc-052827	Lepisosteus oculatus	78.44	0.00e+00	1122.00
IUUC-Laf-054009	Loxodonta africana	86.73	0.00e+00	1174.00
IUUC-Mcc-055054	Macaca mulatta	90.57	0.00e+00	1226.00
IUUC-Meu-056269	Macropus eugenii	78.57	0.00e+00	709.00
IUUC-Mla-059044	Melampsora laricipopulina	24.52	2.00e-19	91.70
IUUC-Mga-060106	Meleagris gallopavo	86.28	0.00e+00	1191.00
IUUC-Mmr-061118	Microcebus murinus	88.32	0.00e+00	1210.00
IUUC-Mdo-062380	Monodelphis domestica	90.96	0.00e+00	1227.00
IUUC-Mmu-063135	Mus musculus	90.80	0.00e+00	1254.00
IUUC-Mpu-066135	Mustela putorius furo	97.10	0.00e+00	1290.00
IUUC-Nle-069465	Nomascus leucogenys	84.93	0.00e+00	1120.00
IUUC-Ont-071945	Oreochromis niloticus	76.48	0.00e+00	1058.00
IUUC-Oan-073384	Ornithorhynchus anatinus	84.37	0.00e+00	1138.00
IUUC-Ola-087499	Oryzias latipes	80.18	0.00e+00	1087.00
IUUC-Oga-088444	Otolemur garnettii	96.34	0.00e+00	1257.00
IUUC-Oar-089576	Ovis aries	88.18	0.00e+00	1201.00
IUUC-Ptr-090507	Pan troglodytes	91.24	0.00e+00	1230.00
IUUC-Pan-092325	Papio anubis	95.73	0.00e+00	1246.00
IUUC-Psi-094021	Pelodiscus sinensis	90.38	0.00e+00	1203.00
IUUC-Pma-094372	Petromyzon marinus	52.32	0.00e+00	698.00
IUUC-Pfo-096732	Poecilia formosa	76.45	0.00e+00	1066.00
IUUC-Pab-098426	Pongo abelii	81.57	0.00e+00	1018.00
IUUC-Pca-100295	Procavia capensis	88.99	0.00e+00	1239.00
IUUC-Rno-105332	Rattus norvegicus	90.22	0.00e+00	1179.00
IUUC-Sha-106529	Sarcophilus harrisii	88.71	0.00e+00	1226.00
IUUC-Sit-110173	Setaria italica	34.09	3.40e-01	30.40
IUUC-Ssc-116176	Sus scrofa	91.00	0.00e+00	1230.00
IUUC-Tgu-116917	Taeniopygia guttata	86.28	0.00e+00	1184.00
IUUC-Tru-118398	Takifugu rubripes	76.24	0.00e+00	968.00
IUUC-Tni-120819	Tetraodon nigroviridis	76.74	0.00e+00	1082.00
IUUC-Xtr-132747	Xenopus tropicalis	78.97	0.00e+00	1051.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence