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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045695
UUCD1 version UUC-HoS-00676
Ensembl Protein ID ENSP00000360690.3
UniProt Accession Q496Y0; Q5JPN6; Q8NB00; Q9H647; LONF3_HUMAN
Genbank Protein ID BAB15419.1; BAC03744.1; AAH99847.1; AAI00672.1; AAI03492.1
Protein Name LON peptidase N-terminal domain and RING finger protein 3; RING finger protein 127
Genbank Nucleotide ID AK026265; AK091777; AL772284; BC100671; BC103491
Gene Name LONRF3; RNF127
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000175556.16 ENST00000481285.5 ENSP00000435426.1
ENSG00000175556.16 ENST00000371628.7 ENSP00000360690.3
ENSG00000175556.16 ENST00000439603.5 ENSP00000414519.1
ENSG00000175556.16 ENST00000304778.11 ENSP00000307732.7
ENSG00000175556.16 ENST00000422289.3 ENSP00000408894.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbGWAS Central
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 9.20e-11 43.3 464 531
E3 activity/RING/RING 2.50e-08 36.0 467 505
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpl....teedlvPnltlrrliqawc 69
           ++ C++ + l+ +Pv++p+G+t+  +++e++l+++ k cP+++  l    ++++   n  + +li +++
   Q: 464  DLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAK-CPLCKDGLsqclASRKYSKNVIMEELIAKFL 531
           678*********************************9.****876633336777788888888887776 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C+  f + p+++pCgH+f+++Cl++          +++CPlC+
   Q: 467  CALCMRLFYE-PVTTPCGHTFCLKCLERC------LDHNAKCPLCK 505
           ****999977.***************999......9*********7 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MESVRIEQML SLPAEVSSDN LESAERGASA AQVDMGPHPK VAAEGPAPLP TREPEQEQSP 60
GTSTPESKVL LTQADALASR GRIREALEVY RQLSERQQLV AEQLEQLVRC LAEKVPQGEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045695|E3,U-box;E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTATTAGG CGGCGCGGGG CGGCCGGCAT GGAGCTCCCG GAGGCGCGGC AGGGTCAGGA 60
GCTCGGTGGC ATGGCGGCGG TGGCTGCCCC GATTTCCTCC AGCTGCCACT CCTTGCTTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045695|E3,U-box;E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51787--LON_N
PS50005--TPR
PS50293--TPR_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02190--LON_substr_bdg
SMART

SM00464--LON
SM00184--RING
SM00028--TPR
Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
KEGG hsa:79836
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000755 Aegilops tauschii 30.53 3.00e-11 63.20
IUUC-Aml-001774 Ailuropoda melanoleuca 77.21 0.00e+00 991.00
IUUC-Apl-003916 Anas platyrhynchos 61.15 0.00e+00 627.00
IUUC-Bta-012872 Bos taurus 87.24 0.00e+00 1142.00
IUUC-Cel-018356 Caenorhabditis elegans 32.53 8.00e-10 56.20
IUUC-Cja-018747 Callithrix jacchus 86.48 0.00e+00 1141.00
IUUC-Cfa-020101 Canis familiaris 84.35 0.00e+00 1106.00
IUUC-Cpo-022041 Cavia porcellus 76.95 0.00e+00 998.00
IUUC-Csa-024034 Chlorocebus sabaeus 98.02 0.00e+00 1365.00
IUUC-Csv-026364 Ciona savignyi 45.87 6.00e-79 288.00
IUUC-Dno-029518 Dasypus novemcinctus 77.98 0.00e+00 1018.00
IUUC-Dor-031132 Dipodomys ordii 70.60 0.00e+00 989.00
IUUC-Dse-031331 Dothistroma septosporum 29.46 3.00e-39 156.00
IUUC-Eca-033382 Equus caballus 88.54 0.00e+00 1229.00
IUUC-Fca-035777 Felis catus 77.98 0.00e+00 722.00
IUUC-Fal-036730 Ficedula albicollis 61.58 0.00e+00 647.00
IUUC-Gmo-039110 Gadus morhua 47.83 4.00e-174 605.00
IUUC-Gga-041187 Gallus gallus 57.11 0.00e+00 818.00
IUUC-Gac-042201 Gasterosteus aculeatus 50.28 0.00e+00 658.00
IUUC-Ggo-045111 Gorilla gorilla 99.60 0.00e+00 1377.00
IUUC-Lch-050429 Latimeria chalumnae 51.52 0.00e+00 726.00
IUUC-Loc-051823 Lepisosteus oculatus 52.34 0.00e+00 659.00
IUUC-Lma-053145 Leptosphaeria maculans 31.55 9.00e-41 161.00
IUUC-Laf-053434 Loxodonta africana 87.29 0.00e+00 897.00
IUUC-Mcc-055249 Macaca mulatta 89.26 0.00e+00 863.00
IUUC-Mga-060131 Meleagris gallopavo 62.30 0.00e+00 627.00
IUUC-Mmr-060749 Microcebus murinus 88.86 0.00e+00 1247.00
IUUC-Mdo-062261 Monodelphis domestica 55.49 0.00e+00 742.00
IUUC-Mmu-063219 Mus musculus 79.84 0.00e+00 1078.00
IUUC-Mpu-066222 Mustela putorius furo 75.79 0.00e+00 989.00
IUUC-Mlu-067769 Myotis lucifugus 83.82 0.00e+00 1125.00
IUUC-Nle-069738 Nomascus leucogenys 98.43 0.00e+00 1066.00
IUUC-Ont-072029 Oreochromis niloticus 56.37 2.00e-171 596.00
IUUC-Oan-073179 Ornithorhynchus anatinus 79.42 3.00e-167 582.00
IUUC-Ocu-074884 Oryctolagus cuniculus 84.40 0.00e+00 1099.00
IUUC-Ogl-077658 Oryza glaberrima 34.04 5.00e-12 65.50
IUUC-Ome-081482 Oryza meridionalis 34.04 8.00e-12 64.70
IUUC-Osa-085978 Oryza sativa 34.04 5.00e-12 65.50
IUUC-Ola-086534 Oryzias latipes 40.00 7.00e-156 544.00
IUUC-Oga-089109 Otolemur garnettii 84.82 0.00e+00 1133.00
IUUC-Oar-089903 Ovis aries 87.63 0.00e+00 1152.00
IUUC-Ptr-091238 Pan troglodytes 99.34 0.00e+00 1369.00
IUUC-Pan-092379 Papio anubis 91.49 0.00e+00 1350.00
IUUC-Psi-093418 Pelodiscus sinensis 60.60 0.00e+00 711.00
IUUC-Pma-094231 Petromyzon marinus 63.60 1.00e-109 389.00
IUUC-Pno-094889 Phaeosphaeria nodorum 38.68 2.00e-41 163.00
IUUC-Pfo-097284 Poecilia formosa 48.36 7.00e-176 610.00
IUUC-Pab-098343 Pongo abelii 92.48 0.00e+00 1336.00
IUUC-Pca-100905 Procavia capensis 81.31 0.00e+00 982.00
IUUC-Pva-102242 Pteropus vampyrus 80.95 0.00e+00 1080.00
IUUC-Ptt-103898 Puccinia triticina 26.32 3.00e-28 120.00
IUUC-Rno-105899 Rattus norvegicus 76.23 0.00e+00 1092.00
IUUC-Sha-107565 Sarcophilus harrisii 51.18 0.00e+00 700.00
IUUC-Sja-107742 Schizosaccharomyces japonicus 36.89 9.00e-31 128.00
IUUC-Spo-108344 Schizosaccharomyces pombe 35.03 1.00e-24 108.00
IUUC-Sar-112999 Sorex araneus 63.67 0.00e+00 660.00
IUUC-Sre-114977 Sporisorium reilianum 33.85 3.00e-35 144.00
IUUC-Ssc-115705 Sus scrofa 87.78 0.00e+00 1190.00
IUUC-Tgu-116978 Taeniopygia guttata 64.64 0.00e+00 791.00
IUUC-Tsy-118988 Tarsius syrichta 93.20 0.00e+00 947.00
IUUC-Tbe-127563 Tupaia belangeri 70.94 1.00e-144 506.00
IUUC-Ttr-128875 Tursiops truncatus 86.69 0.00e+00 1086.00
IUUC-Vpa-130779 Vicugna pacos 95.82 2.00e-159 555.00
IUUC-Xtr-132508 Xenopus tropicalis 52.86 0.00e+00 733.00
Created Date 25-Jun-2017

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