iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.10e-15	56.5	1399	1439

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1399 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1439
           8*********....*******************....99996.******8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MCHPKKKSTP LKYEVGDLIW AKFKRRPWWP CRICSDPLIN THSKMKVANR RPYREYYVEA 60
FGDPSEKAWV AGKAIVMFEG RHQFEELPVL RKRGKQKEKG YRHKVPQKIL SKWEASVGLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTTTGCTT TGCTGCTGAG TGTTGACGAG TGCCAACAGC GCTGCCGGGA GGTGCTGCCG 60
CGGCTGTGGG AAGGAGCGCG GCCCGGACAG GCGGCGTCGG CGACGGCAGC AGCCATGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-0675--Receptor
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

KEGG

rno:306764

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000310	Aegilops tauschii	28.65	7.00e-12	65.90
IUUC-Aml-001795	Ailuropoda melanoleuca	82.73	0.00e+00	3796.00
IUUC-Apl-003953	Anas platyrhynchos	56.43	0.00e+00	2150.00
IUUC-Aca-005339	Anolis carolinensis	60.47	0.00e+00	1558.00
IUUC-Bta-012966	Bos taurus	82.26	0.00e+00	3826.00
IUUC-Bol-016001	Brassica oleracea	29.51	5.00e-17	84.00
IUUC-Bra-017864	Brassica rapa	28.96	8.00e-16	80.10
IUUC-Cja-018780	Callithrix jacchus	82.75	0.00e+00	3561.00
IUUC-Cfa-020975	Canis familiaris	82.64	0.00e+00	3813.00
IUUC-Cpo-021331	Cavia porcellus	84.96	0.00e+00	2607.00
IUUC-Csa-024226	Chlorocebus sabaeus	82.87	0.00e+00	3779.00
IUUC-Cho-024464	Choloepus hoffmanni	70.63	0.00e+00	1253.00
IUUC-Dre-027488	Danio rerio	77.68	0.00e+00	1259.00
IUUC-Dno-029230	Dasypus novemcinctus	79.14	0.00e+00	3580.00
IUUC-Dor-031016	Dipodomys ordii	79.76	0.00e+00	1312.00
IUUC-Dme-032193	Drosophila melanogaster	36.38	3.00e-124	440.00
IUUC-Eca-033591	Equus caballus	82.84	0.00e+00	3846.00
IUUC-Fca-035791	Felis catus	83.18	0.00e+00	3917.00
IUUC-Fal-037378	Ficedula albicollis	56.17	0.00e+00	2015.00
IUUC-Gmo-038919	Gadus morhua	71.61	0.00e+00	942.00
IUUC-Gga-040881	Gallus gallus	55.53	0.00e+00	2122.00
IUUC-Gac-041378	Gasterosteus aculeatus	78.51	0.00e+00	1069.00
IUUC-Hsa-046436	Homo sapiens	83.33	0.00e+00	3817.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	83.31	0.00e+00	3897.00
IUUC-Lch-049684	Latimeria chalumnae	49.54	0.00e+00	1549.00
IUUC-Lpe-051201	Leersia perrieri	30.05	6.00e-11	62.80
IUUC-Laf-054046	Loxodonta africana	81.92	0.00e+00	3711.00
IUUC-Mcc-055593	Macaca mulatta	82.79	0.00e+00	3784.00
IUUC-Mga-059756	Meleagris gallopavo	55.15	0.00e+00	2175.00
IUUC-Mmr-061182	Microcebus murinus	82.63	0.00e+00	3846.00
IUUC-Mdo-061984	Monodelphis domestica	65.17	0.00e+00	2793.00
IUUC-Mmu-063605	Mus musculus	92.71	0.00e+00	4348.00
IUUC-Mpu-066446	Mustela putorius furo	82.69	0.00e+00	3877.00
IUUC-Mlu-067261	Myotis lucifugus	81.66	0.00e+00	3734.00
IUUC-Nle-069818	Nomascus leucogenys	83.05	0.00e+00	3801.00
IUUC-Opr-070842	Ochotona princeps	79.47	0.00e+00	2225.00
IUUC-Ont-072448	Oreochromis niloticus	75.82	0.00e+00	1160.00
IUUC-Oan-073496	Ornithorhynchus anatinus	75.05	0.00e+00	1634.00
IUUC-Ocu-074918	Oryctolagus cuniculus	82.96	0.00e+00	3883.00
IUUC-Obr-076122	Oryza brachyantha	29.76	1.00e-09	57.00
IUUC-Ola-087518	Oryzias latipes	76.70	0.00e+00	1066.00
IUUC-Oga-088743	Otolemur garnettii	81.52	0.00e+00	3707.00
IUUC-Oar-090265	Ovis aries	82.05	0.00e+00	3812.00
IUUC-Ptr-090521	Pan troglodytes	83.34	0.00e+00	3819.00
IUUC-Psi-093245	Pelodiscus sinensis	58.36	0.00e+00	2011.00
IUUC-Pfo-096066	Poecilia formosa	76.83	0.00e+00	1202.00
IUUC-Pab-098644	Pongo abelii	82.76	0.00e+00	3774.00
IUUC-Pva-103094	Pteropus vampyrus	78.09	0.00e+00	1861.00
IUUC-Sha-107278	Sarcophilus harrisii	66.52	0.00e+00	2856.00
IUUC-Sar-113402	Sorex araneus	73.34	0.00e+00	2372.00
IUUC-Sbi-114400	Sorghum bicolor	37.50	8.00e-14	68.90
IUUC-Ssc-116193	Sus scrofa	81.90	0.00e+00	3724.00
IUUC-Tgu-116532	Taeniopygia guttata	90.15	0.00e+00	1261.00
IUUC-Tru-117988	Takifugu rubripes	77.79	0.00e+00	1202.00
IUUC-Tsy-118830	Tarsius syrichta	82.39	0.00e+00	3358.00
IUUC-Tca-121456	Theobroma cacao	30.33	2.00e-19	91.30
IUUC-Tae-124687	Triticum aestivum	28.65	7.00e-12	65.90
IUUC-Xma-133606	Xiphophorus maculatus	77.40	0.00e+00	1141.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence