iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026932.14	ENSMUST00000114159.8	ENSMUSP00000109796.2
ENSMUSG00000026932.14	ENSMUST00000140993.1	ENSMUSP00000120198.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.30e-15	58.6	30	92

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv +vv+g+ f+ah++vLaasS +F++lf+++     sk+  e+ + v p +f+++l+F+Ytgkl++
   Q: 30   CDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN-----SKSAFELPGtVPPACFQQILSFCYTGKLTM 92
           8*****************************774.....46778***88*****************986 PP

Organism

Mus musculus

Functional Description
(View)

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity).

Protein Sequence
(Fasta)

MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA SSLYFRDLFS 60
GNSKSAFELP GTVPPACFQQ ILSFCYTGKL TMAASEQLVV MYTAGFLQIQ HIVERGTDLM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCCCACTG GGCCTCTATA TTGCAAGAGC CTCCTCCACA TGGCTGTAAG TCGGTGGGCA 60
GCAGGCACCA GAGCCCGGTG GTACTTATTC CAAGGCTGCT CAGTCACGCG ATTTGCCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR018379--BEN_domain
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS51457--BEN
PS50097--BTB

Pfam

PF10523--BEN
PF00651--BTB

SMART

SM01025--BEN
SM00225--BTB

Gene Ontology

GO:0005739--C:mitochondrion
GO:0000790--C:nuclear chromatin
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0042803--F:protein homodimerization activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001076--F:transcription factor activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0034629--P:cellular protein complex localization
GO:0008285--P:negative regulation of cell proliferation
GO:1900477--P:negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0051260--P:protein homooligomerization

KEGG

mmu:67991

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001902	Ailuropoda melanoleuca	90.10	0.00e+00	837.00
IUUC-Apl-004203	Anas platyrhynchos	80.58	0.00e+00	948.00
IUUC-Ame-011046	Astyanax mexicanus	56.01	2.00e-148	518.00
IUUC-Bta-012908	Bos taurus	91.79	0.00e+00	957.00
IUUC-Cja-019140	Callithrix jacchus	90.82	0.00e+00	1034.00
IUUC-Cfa-020493	Canis familiaris	90.14	2.00e-168	585.00
IUUC-Cpo-022399	Cavia porcellus	90.85	0.00e+00	1058.00
IUUC-Csa-024135	Chlorocebus sabaeus	91.00	0.00e+00	1018.00
IUUC-Dre-027761	Danio rerio	70.45	4.00e-81	295.00
IUUC-Dno-029271	Dasypus novemcinctus	77.80	0.00e+00	741.00
IUUC-Ete-032427	Echinops telfairi	84.43	0.00e+00	897.00
IUUC-Eca-033986	Equus caballus	89.98	0.00e+00	1012.00
IUUC-Eeu-035211	Erinaceus europaeus	89.27	0.00e+00	988.00
IUUC-Fca-035733	Felis catus	89.64	0.00e+00	909.00
IUUC-Fal-037348	Ficedula albicollis	82.68	0.00e+00	950.00
IUUC-Gmo-039529	Gadus morhua	81.95	1.00e-94	339.00
IUUC-Gga-040405	Gallus gallus	83.65	0.00e+00	981.00
IUUC-Gac-041308	Gasterosteus aculeatus	68.37	2.00e-174	605.00
IUUC-Ggo-044687	Gorilla gorilla	70.95	0.00e+00	780.00
IUUC-Hsa-045955	Homo sapiens	89.47	0.00e+00	997.00
IUUC-Itr-048872	Ictidomys tridecemlineatus	93.73	0.00e+00	1031.00
IUUC-Lch-049615	Latimeria chalumnae	75.72	0.00e+00	912.00
IUUC-Loc-051881	Lepisosteus oculatus	70.19	0.00e+00	687.00
IUUC-Lma-053325	Leptosphaeria maculans	36.84	1.00e-06	47.00
IUUC-Laf-054170	Loxodonta africana	86.24	0.00e+00	952.00
IUUC-Mga-059627	Meleagris gallopavo	82.79	0.00e+00	974.00
IUUC-Mdo-063014	Monodelphis domestica	85.55	1.00e-176	612.00
IUUC-Mpu-066806	Mustela putorius furo	88.96	0.00e+00	927.00
IUUC-Nle-069114	Nomascus leucogenys	90.61	0.00e+00	921.00
IUUC-Opr-071127	Ochotona princeps	95.35	7.00e-72	265.00
IUUC-Ont-071693	Oreochromis niloticus	68.30	3.00e-176	611.00
IUUC-Oan-073510	Ornithorhynchus anatinus	86.27	0.00e+00	1017.00
IUUC-Ola-086572	Oryzias latipes	64.80	0.00e+00	647.00
IUUC-Oga-088653	Otolemur garnettii	88.76	0.00e+00	1019.00
IUUC-Oar-089811	Ovis aries	88.54	0.00e+00	800.00
IUUC-Ptr-090703	Pan troglodytes	89.12	0.00e+00	984.00
IUUC-Pan-092388	Papio anubis	90.88	0.00e+00	1031.00
IUUC-Psi-093786	Pelodiscus sinensis	83.48	0.00e+00	989.00
IUUC-Pma-094566	Petromyzon marinus	50.99	6.00e-107	381.00
IUUC-Pno-095029	Phaeosphaeria nodorum	29.11	2.00e-05	42.70
IUUC-Pfo-096554	Poecilia formosa	64.57	0.00e+00	633.00
IUUC-Pca-101090	Procavia capensis	87.35	0.00e+00	958.00
IUUC-Pva-102843	Pteropus vampyrus	89.13	0.00e+00	976.00
IUUC-Rno-105139	Rattus norvegicus	97.78	0.00e+00	1133.00
IUUC-Sha-107545	Sarcophilus harrisii	86.22	0.00e+00	1001.00
IUUC-Tgu-117401	Taeniopygia guttata	82.62	0.00e+00	962.00
IUUC-Tru-118080	Takifugu rubripes	67.65	5.00e-169	587.00
IUUC-Tni-120321	Tetraodon nigroviridis	64.62	9.00e-171	593.00
IUUC-Ttr-128369	Tursiops truncatus	91.39	0.00e+00	719.00
IUUC-Xtr-131793	Xenopus tropicalis	78.27	8.00e-156	543.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence