iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055401

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03023666

Gene Name

CISH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000010497.3	ENSMMUT00000014688.3	ENSMMUP00000013759.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.10e-14	55.1	216	263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           l++++++rs+ rSLqhLCRl+I+r++++     +d+LPLP+++ dYL+++++q
   Q: 216  LVQPFVRRSSARSLQHLCRLVINRLVTD-----VDCLPLPRRMADYLRQYPFQ 263
           57999***********************.....8****************986 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGPPLTAHPL LSRPRPLLAV ERTGQRPLWA QSLELLETVM QPLPAGAFLE EVAEGTPAQI 60
ESEPKVLDPE EDLLCIAKTF SYLRESGWYW GSITASEARQ HLQKMPEGTF LVRDSTHPSY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTCCTC CACTCACTGC TCATCCACTG CTTTCTAGAC CTCGTCCTTT GCTGGCTGTG 60
GAGCGGACTG GGCAGCGGCC CCTGTGGGCC CAGTCCCTAG AACTGCTCGA GACAGTCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	90.48	9.00e-112	395.00
IUUC-Aca-004372	Anolis carolinensis	63.89	6.00e-84	303.00
IUUC-Ame-010787	Astyanax mexicanus	48.25	1.00e-49	189.00
IUUC-Bta-012826	Bos taurus	87.95	6.00e-116	409.00
IUUC-Cja-020004	Callithrix jacchus	93.36	2.00e-117	414.00
IUUC-Cfa-020150	Canis familiaris	89.33	1.00e-107	382.00
IUUC-Csa-023173	Chlorocebus sabaeus	99.62	3.00e-132	463.00
IUUC-Dre-028606	Danio rerio	44.44	7.00e-33	133.00
IUUC-Dno-028956	Dasypus novemcinctus	86.56	1.00e-111	395.00
IUUC-Dor-030148	Dipodomys ordii	73.90	4.00e-93	333.00
IUUC-Ete-032313	Echinops telfairi	81.34	6.00e-102	363.00
IUUC-Eca-033422	Equus caballus	89.64	5.00e-117	413.00
IUUC-Eeu-034806	Erinaceus europaeus	88.59	2.00e-114	404.00
IUUC-Fca-036374	Felis catus	88.45	2.00e-115	407.00
IUUC-Fal-036801	Ficedula albicollis	64.96	1.00e-81	295.00
IUUC-Gmo-038483	Gadus morhua	40.57	3.00e-34	138.00
IUUC-Gga-040891	Gallus gallus	66.40	4.00e-79	287.00
IUUC-Gac-042147	Gasterosteus aculeatus	43.19	2.00e-32	132.00
IUUC-Ggo-045511	Gorilla gorilla	95.67	9.00e-116	409.00
IUUC-Hsa-046678	Homo sapiens	96.41	2.00e-116	411.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	83.21	1.00e-116	412.00
IUUC-Lch-050555	Latimeria chalumnae	55.60	2.00e-69	255.00
IUUC-Laf-054141	Loxodonta africana	86.11	2.00e-111	394.00
IUUC-Meu-056592	Macropus eugenii	68.25	7.00e-91	326.00
IUUC-Mga-059515	Meleagris gallopavo	65.76	8.00e-79	286.00
IUUC-Mmr-060848	Microcebus murinus	90.84	1.00e-118	419.00
IUUC-Mdo-062720	Monodelphis domestica	66.14	2.00e-87	315.00
IUUC-Mmu-063348	Mus musculus	87.95	6.00e-121	426.00
IUUC-Mpu-065834	Mustela putorius furo	77.90	4.00e-109	387.00
IUUC-Mlu-067687	Myotis lucifugus	76.72	1.00e-91	329.00
IUUC-Nle-069277	Nomascus leucogenys	96.02	3.00e-117	414.00
IUUC-Ont-071890	Oreochromis niloticus	45.83	7.00e-36	143.00
IUUC-Oan-073672	Ornithorhynchus anatinus	69.96	4.00e-83	300.00
IUUC-Ocu-073875	Oryctolagus cuniculus	88.54	1.00e-112	398.00
IUUC-Ola-087140	Oryzias latipes	55.29	1.00e-23	102.00
IUUC-Oga-087943	Otolemur garnettii	88.84	3.00e-110	390.00
IUUC-Oar-090194	Ovis aries	87.30	6.00e-116	409.00
IUUC-Ptr-090934	Pan troglodytes	95.67	7.00e-116	409.00
IUUC-Pan-092121	Papio anubis	100.00	2.00e-124	437.00
IUUC-Psi-093733	Pelodiscus sinensis	62.20	2.00e-83	301.00
IUUC-Pfo-096313	Poecilia formosa	48.02	3.00e-43	167.00
IUUC-Pab-098439	Pongo abelii	96.02	1.00e-115	408.00
IUUC-Pca-101010	Procavia capensis	86.51	2.00e-109	388.00
IUUC-Pva-103112	Pteropus vampyrus	87.95	1.00e-119	421.00
IUUC-Rno-105917	Rattus norvegicus	82.06	4.00e-107	380.00
IUUC-Sha-106954	Sarcophilus harrisii	66.14	6.00e-89	320.00
IUUC-Smo-109292	Selaginella moellendorffii	31.15	2.10e-01	30.80
IUUC-Sar-113001	Sorex araneus	87.45	2.00e-111	394.00
IUUC-Ssc-115922	Sus scrofa	91.04	1.00e-60	224.00
IUUC-Tgu-117338	Taeniopygia guttata	64.57	1.00e-81	296.00
IUUC-Tru-118511	Takifugu rubripes	44.32	1.00e-31	129.00
IUUC-Tsy-119434	Tarsius syrichta	88.05	5.00e-112	396.00
IUUC-Tni-119837	Tetraodon nigroviridis	42.64	9.00e-29	119.00
IUUC-Ttr-128340	Tursiops truncatus	73.71	1.00e-73	269.00
IUUC-Vpa-130443	Vicugna pacos	88.84	1.00e-122	432.00
IUUC-Xtr-131784	Xenopus tropicalis	63.50	3.00e-64	238.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence