iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054009

UUCD1 version

UUC-LoA-00405

Ensembl Protein ID

ENSLAFP00000008773.4

UniProt Accession

G3T5P5; G3T5P5_LOXAF

Protein Name

Uncharacterized protein

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000010474.4	ENSLAFT00000010477.4	ENSLAFP00000008773.4
ENSLAFG00000010474.4	ENSLAFT00000031118.1	ENSLAFP00000020938.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.80e-17	62.4	811	862

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 811  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--EANGRIGWFPSTYVEE 862
           67**********************************..9*************86 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MEQWRQCGRW LIDCKVLPPN HRVVWPSAAV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCAGT GGCGGCAGTG CGGCCGCTGG CTCATCGACT GCAAGGTCCT GCCGCCCAAC 60
CACCGGGTCG TGTGGCCCTC GGCTGCGGTC TTCGACCTGG CTCAGGCGCT GCGCGATGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	90.18	0.00e+00	1394.00
IUUC-Apl-003262	Anas platyrhynchos	86.41	0.00e+00	1454.00
IUUC-Ath-007352	Arabidopsis thaliana	37.70	2.00e-04	40.80
IUUC-Ame-011608	Astyanax mexicanus	76.08	0.00e+00	1343.00
IUUC-Bta-013147	Bos taurus	88.69	0.00e+00	1240.00
IUUC-Cja-018877	Callithrix jacchus	87.05	0.00e+00	1308.00
IUUC-Cfa-020315	Canis familiaris	87.32	0.00e+00	1162.00
IUUC-Cpo-021543	Cavia porcellus	89.01	0.00e+00	1246.00
IUUC-Cre-022802	Chlamydomonas reinhardtii	42.31	1.50e+00	29.60
IUUC-Csa-024204	Chlorocebus sabaeus	88.95	0.00e+00	1516.00
IUUC-Dre-028308	Danio rerio	78.05	0.00e+00	1372.00
IUUC-Dno-029584	Dasypus novemcinctus	83.06	0.00e+00	1061.00
IUUC-Dor-031014	Dipodomys ordii	78.06	0.00e+00	1139.00
IUUC-Eca-033448	Equus caballus	88.62	0.00e+00	1502.00
IUUC-Eeu-035182	Erinaceus europaeus	79.58	1.00e-171	597.00
IUUC-Fca-035460	Felis catus	88.56	0.00e+00	1240.00
IUUC-Fal-036684	Ficedula albicollis	84.88	0.00e+00	1458.00
IUUC-Gmo-038816	Gadus morhua	71.54	0.00e+00	1025.00
IUUC-Gga-040999	Gallus gallus	84.00	0.00e+00	1432.00
IUUC-Gac-041353	Gasterosteus aculeatus	73.05	0.00e+00	1077.00
IUUC-Ggo-044558	Gorilla gorilla	90.56	0.00e+00	1524.00
IUUC-Hsa-046208	Homo sapiens	90.67	0.00e+00	1527.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	84.65	0.00e+00	1108.00
IUUC-Loc-052827	Lepisosteus oculatus	77.26	0.00e+00	1386.00
IUUC-Mcc-055054	Macaca mulatta	90.56	0.00e+00	1525.00
IUUC-Mga-060106	Meleagris gallopavo	86.88	0.00e+00	1461.00
IUUC-Mmr-061118	Microcebus murinus	89.64	0.00e+00	1506.00
IUUC-Mdo-062380	Monodelphis domestica	83.18	0.00e+00	1196.00
IUUC-Mmu-063135	Mus musculus	91.60	0.00e+00	1553.00
IUUC-Mpu-066135	Mustela putorius furo	87.28	0.00e+00	1355.00
IUUC-Nle-069465	Nomascus leucogenys	84.00	0.00e+00	1389.00
IUUC-Ont-071945	Oreochromis niloticus	78.82	0.00e+00	1354.00
IUUC-Oan-073384	Ornithorhynchus anatinus	82.60	0.00e+00	1130.00
IUUC-Ola-087499	Oryzias latipes	73.30	0.00e+00	1011.00
IUUC-Olu-087583	Ostreococcus lucimarinus	21.79	1.40e-01	33.10
IUUC-Oga-088444	Otolemur garnettii	86.10	0.00e+00	1209.00
IUUC-Oar-089576	Ovis aries	84.34	0.00e+00	1134.00
IUUC-Ptr-090507	Pan troglodytes	91.71	0.00e+00	1528.00
IUUC-Pan-092325	Papio anubis	88.49	0.00e+00	1471.00
IUUC-Psi-094021	Pelodiscus sinensis	84.22	0.00e+00	1424.00
IUUC-Pma-094372	Petromyzon marinus	51.01	0.00e+00	655.00
IUUC-Pfo-096732	Poecilia formosa	78.17	0.00e+00	1355.00
IUUC-Pab-098426	Pongo abelii	78.11	0.00e+00	1146.00
IUUC-Pca-100295	Procavia capensis	90.95	0.00e+00	1434.00
IUUC-Rno-105332	Rattus norvegicus	91.48	0.00e+00	1475.00
IUUC-Sha-106529	Sarcophilus harrisii	87.43	0.00e+00	1179.00
IUUC-Sit-110173	Setaria italica	34.09	1.70e-01	31.20
IUUC-Ssc-116176	Sus scrofa	89.73	0.00e+00	1371.00
IUUC-Tgu-116917	Taeniopygia guttata	85.19	0.00e+00	1320.00
IUUC-Tru-118398	Takifugu rubripes	74.48	0.00e+00	925.00
IUUC-Tni-120819	Tetraodon nigroviridis	75.98	0.00e+00	1139.00
IUUC-Xtr-132747	Xenopus tropicalis	74.97	0.00e+00	1277.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence