iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-090507

Ensembl Protein ID

ENSPTRP00000036840.5

UniProt Accession

H2QY48; H2QY48_PANTR

Genbank Protein ID

ENSPTRP00000036840

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03070487

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000021525.6	ENSPTRT00000039868.5	ENSPTRP00000036840.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-17	63.6	812	863

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 812  ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 863
           67**********************************..9*************86 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCCATGGA GCAGTGGCGG CAGTGCGGCC GCTGGCTCAT CGACTGCAAG GTCCTGCCGC 60
CCAACCACCG GGTGGTGTGG CCCTCGGCCG TGGTCTTCGA CCTGGCGCAG GCGCTGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	93.17	0.00e+00	1463.00
IUUC-Apl-003262	Anas platyrhynchos	90.78	0.00e+00	1542.00
IUUC-Aca-004628	Anolis carolinensis	66.49	0.00e+00	915.00
IUUC-Ath-007352	Arabidopsis thaliana	38.60	6.00e-04	39.30
IUUC-Ame-011608	Astyanax mexicanus	78.57	0.00e+00	1393.00
IUUC-Bta-013147	Bos taurus	93.74	0.00e+00	1316.00
IUUC-Cel-018578	Caenorhabditis elegans	27.75	1.00e-95	345.00
IUUC-Cja-018877	Callithrix jacchus	93.71	0.00e+00	1419.00
IUUC-Cfa-020315	Canis familiaris	91.82	0.00e+00	1249.00
IUUC-Cpo-021543	Cavia porcellus	92.48	0.00e+00	1332.00
IUUC-Csa-024204	Chlorocebus sabaeus	96.32	0.00e+00	1645.00
IUUC-Cin-025115	Ciona intestinalis	36.63	5.00e-144	505.00
IUUC-Csv-025995	Ciona savignyi	36.44	8.00e-147	514.00
IUUC-Dre-028308	Danio rerio	80.75	0.00e+00	1435.00
IUUC-Dno-029584	Dasypus novemcinctus	87.78	0.00e+00	1147.00
IUUC-Dor-031014	Dipodomys ordii	81.94	0.00e+00	1211.00
IUUC-Eca-033448	Equus caballus	92.37	0.00e+00	1587.00
IUUC-Eeu-035182	Erinaceus europaeus	83.79	0.00e+00	666.00
IUUC-Fca-035460	Felis catus	92.86	0.00e+00	1329.00
IUUC-Fal-036684	Ficedula albicollis	89.57	0.00e+00	1549.00
IUUC-Gmo-038816	Gadus morhua	74.87	0.00e+00	1080.00
IUUC-Gga-040999	Gallus gallus	88.48	0.00e+00	1526.00
IUUC-Gac-041353	Gasterosteus aculeatus	76.04	0.00e+00	1131.00
IUUC-Ggo-044558	Gorilla gorilla	98.52	0.00e+00	1656.00
IUUC-Hsa-046208	Homo sapiens	98.63	0.00e+00	1658.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	89.77	0.00e+00	1196.00
IUUC-Loc-052827	Lepisosteus oculatus	80.61	0.00e+00	1435.00
IUUC-Laf-054009	Loxodonta africana	91.08	0.00e+00	1550.00
IUUC-Mcc-055054	Macaca mulatta	98.29	0.00e+00	1654.00
IUUC-Mga-060106	Meleagris gallopavo	91.47	0.00e+00	1553.00
IUUC-Mmr-061118	Microcebus murinus	94.59	0.00e+00	1603.00
IUUC-Mdo-062380	Monodelphis domestica	87.89	0.00e+00	1280.00
IUUC-Mmu-063135	Mus musculus	95.85	0.00e+00	1648.00
IUUC-Mpu-066135	Mustela putorius furo	89.86	0.00e+00	1429.00
IUUC-Nle-069465	Nomascus leucogenys	91.94	0.00e+00	1519.00
IUUC-Ont-071945	Oreochromis niloticus	81.53	0.00e+00	1399.00
IUUC-Oan-073384	Ornithorhynchus anatinus	87.83	0.00e+00	1214.00
IUUC-Ola-087499	Oryzias latipes	75.80	0.00e+00	1063.00
IUUC-Oga-088444	Otolemur garnettii	92.59	0.00e+00	1307.00
IUUC-Oar-089576	Ovis aries	88.58	0.00e+00	1214.00
IUUC-Pan-092325	Papio anubis	95.85	0.00e+00	1599.00
IUUC-Psi-094021	Pelodiscus sinensis	88.47	0.00e+00	1513.00
IUUC-Pma-094372	Petromyzon marinus	53.03	0.00e+00	701.00
IUUC-Pfo-096732	Poecilia formosa	81.31	0.00e+00	1409.00
IUUC-Pab-098426	Pongo abelii	81.86	0.00e+00	1186.00
IUUC-Pca-100295	Procavia capensis	93.00	0.00e+00	1482.00
IUUC-Rno-105332	Rattus norvegicus	95.05	0.00e+00	1566.00
IUUC-Sha-106529	Sarcophilus harrisii	92.62	0.00e+00	1262.00
IUUC-Ssc-116176	Sus scrofa	93.80	0.00e+00	1456.00
IUUC-Tgu-116917	Taeniopygia guttata	91.01	0.00e+00	1415.00
IUUC-Tru-118398	Takifugu rubripes	79.27	0.00e+00	979.00
IUUC-Tni-120819	Tetraodon nigroviridis	79.90	0.00e+00	1197.00
IUUC-Xtr-132747	Xenopus tropicalis	79.17	0.00e+00	1355.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence