iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037131

Ensembl Protein ID

ENSFALP00000007268.1

UniProt Accession

U3JWW4; U3JWW4_FICAL

Genbank Protein ID

ENSFALP00000007268

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01010283

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000006962.1	ENSFALT00000007300.1	ENSFALP00000007268.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-96	323.7	1682	2061

Active Site

Position(s)	Description	Evidence
2028	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp..................ehlklFe 72
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++++n                   ++   F+
   Q: 1682 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLANPKgsQEGTKYIHNLqglfalpfgrtakpahiaKVKMKFR 1767
           56899***********.**********************766663333330023334444448999999**********9999**** PP
   S: 73   flGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikenaes........................... 130
           flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp ++ks+  +++ + +                           
   Q: 1768 FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFSIDPVVAKSIYHLEDIVRQkkrleqdktqtkeslqyalealtmngc 1854
           *******************************654444*************9999999833344555566666667555555555544 PP
   S: 131  dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFtee 212
           ++e+            +     l+   + eLk gG+++pVt+ N+eeY +lv+ + l+eg+++q+++fr+Gf++v+pl++l++F +e
   Q: 1855 SVED------------LgldftLPGFPNIELKKGGKDTPVTIHNLEEYLRLVIFWALNEGVARQFDSFRDGFESVFPLSHLQYFYPE 1929
           4444............24444478999************************************************************ PP
   S: 213  elellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....d 292
           ele+l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f+se+++ fLqFvTgs+rlP+gGf++l+p l+++rk     +
   Q: 1930 ELEQLLCGSktDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSSFDSEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfestE 2016
           ********97778999999999999***********************************************************988 PP
   S: 293  asddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           + dd lPs++TC+nyLkLP+Ys+ ei++ekLl+A +e+ ++F+ls
   Q: 2017 NPDDFLPSVMTCVNYLKLPDYSTIEIMREKLLIAAREGqQSFHLS 2061
           888***************************************985 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDAV GGRSHLGQAK HKAHSPPENR KSISKTPKVQ 60
SNTTSEQSKG HFSKRGCSSS AVLIPQQEDP ERVDTSEKQK TGQVPKKDNS RGVKRSASPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGATAG TGTCTAGAAA GGGTATGTCC CTTCAGGAGA GAGGTGCCAA TGTCCAACCG 60
GCCTAATAAC AATCCAGGGG GGTCACTGCG ACGTTCACAG AGGAACACTG CCGGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.98	4.00e-128	453.00
IUUC-Aml-001502	Ailuropoda melanoleuca	93.28	0.00e+00	3508.00
IUUC-Atr-002821	Amborella trichopoda	37.73	1.00e-118	421.00
IUUC-Apl-003531	Anas platyrhynchos	94.55	0.00e+00	3504.00
IUUC-Aly-005962	Arabidopsis lyrata	39.09	2.00e-115	411.00
IUUC-Ath-006636	Arabidopsis thaliana	38.80	4.00e-115	410.00
IUUC-Ago-007875	Ashbya gossypii	36.06	2.00e-82	301.00
IUUC-Acl-008242	Aspergillus clavatus	36.05	4.00e-114	406.00
IUUC-Afl-008736	Aspergillus flavus	38.64	1.00e-110	395.00
IUUC-Afu-008812	Aspergillus fumigatus	35.95	3.00e-115	410.00
IUUC-Ani-009407	Aspergillus nidulans	37.27	6.00e-112	399.00
IUUC-Ang-009763	Aspergillus niger	39.78	2.00e-106	380.00
IUUC-Aor-009941	Aspergillus oryzae	30.60	3.00e-112	400.00
IUUC-Ate-010459	Aspergillus terreus	33.61	5.00e-87	316.00
IUUC-Ame-011761	Astyanax mexicanus	88.87	0.00e+00	3005.00
IUUC-Bgr-012265	Blumeria graminis	35.31	3.00e-105	377.00
IUUC-Bta-013070	Bos taurus	90.23	0.00e+00	3404.00
IUUC-Bci-013890	Botrytis cinerea	40.12	3.00e-104	374.00
IUUC-Bdi-014046	Brachypodium distachyon	38.36	3.00e-124	440.00
IUUC-Bol-015942	Brassica oleracea	44.23	7.00e-115	409.00
IUUC-Bra-016849	Brassica rapa	41.21	2.00e-114	408.00
IUUC-Cja-019046	Callithrix jacchus	93.43	0.00e+00	3206.00
IUUC-Cfa-020521	Canis familiaris	91.39	0.00e+00	3394.00
IUUC-Cpo-021639	Cavia porcellus	89.09	0.00e+00	3382.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.27	2.00e-90	326.00
IUUC-Csa-023231	Chlorocebus sabaeus	96.08	0.00e+00	3283.00
IUUC-Cho-024380	Choloepus hoffmanni	89.49	0.00e+00	2073.00
IUUC-Cin-025482	Ciona intestinalis	51.40	4.00e-161	560.00
IUUC-Csv-026121	Ciona savignyi	48.41	0.00e+00	1539.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.49	7.00e-112	399.00
IUUC-Cne-026857	Cryptococcus neoformans	40.08	4.00e-96	347.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.34	3.00e-74	274.00
IUUC-Dre-028174	Danio rerio	88.81	0.00e+00	3054.00
IUUC-Dor-030939	Dipodomys ordii	84.82	0.00e+00	1391.00
IUUC-Dse-031444	Dothistroma septosporum	37.73	5.00e-106	379.00
IUUC-Dme-032162	Drosophila melanogaster	67.73	3.00e-174	607.00
IUUC-Ete-032345	Echinops telfairi	87.41	0.00e+00	2213.00
IUUC-Eca-033229	Equus caballus	92.50	0.00e+00	3434.00
IUUC-Eeu-035205	Erinaceus europaeus	80.99	0.00e+00	2940.00
IUUC-Fca-036444	Felis catus	92.56	0.00e+00	3494.00
IUUC-Fox-038035	Fusarium oxysporum	36.27	6.00e-111	394.00
IUUC-Fso-038320	Fusarium solani	35.91	2.00e-110	394.00
IUUC-Gmo-039497	Gadus morhua	80.48	0.00e+00	3049.00
IUUC-Ggr-040057	Gaeumannomyces graminis	39.10	1.00e-107	385.00
IUUC-Gga-041021	Gallus gallus	98.40	0.00e+00	3675.00
IUUC-Gac-042474	Gasterosteus aculeatus	80.58	0.00e+00	3049.00
IUUC-Gma-043060	Glycine max	39.18	3.00e-122	434.00
IUUC-Ggo-044855	Gorilla gorilla	93.43	0.00e+00	3206.00
IUUC-Hsa-046147	Homo sapiens	93.20	0.00e+00	3209.00
IUUC-Hvu-047775	Hordeum vulgare	38.83	6.00e-126	446.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	92.12	0.00e+00	3392.00
IUUC-Kpa-049098	Komagataella pastoris	38.29	3.00e-86	313.00
IUUC-Lch-049818	Latimeria chalumnae	85.85	0.00e+00	3135.00
IUUC-Lpe-051017	Leersia perrieri	38.75	6.00e-120	426.00
IUUC-Loc-051777	Lepisosteus oculatus	88.23	0.00e+00	3377.00
IUUC-Lma-052990	Leptosphaeria maculans	36.57	3.00e-115	410.00
IUUC-Laf-053727	Loxodonta africana	92.94	0.00e+00	3490.00
IUUC-Mcc-055799	Macaca mulatta	96.15	0.00e+00	3196.00
IUUC-Meu-056065	Macropus eugenii	92.91	0.00e+00	2067.00
IUUC-Mor-057054	Magnaporthe oryzae	38.67	4.00e-107	383.00
IUUC-Mpo-057417	Magnaporthe poae	39.36	4.00e-109	390.00
IUUC-Mtr-057849	Medicago truncatula	37.78	1.00e-114	408.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	1.00e-107	385.00
IUUC-Mga-059580	Meleagris gallopavo	96.63	0.00e+00	3119.00
IUUC-Mvi-060507	Microbotryum violaceum	40.73	5.00e-116	413.00
IUUC-Mmr-060816	Microcebus murinus	94.15	0.00e+00	3569.00
IUUC-Mdo-062866	Monodelphis domestica	92.71	0.00e+00	3375.00
IUUC-Mmu-063906	Mus musculus	92.21	0.00e+00	3474.00
IUUC-Mac-064675	Musa acuminata	39.32	2.00e-114	406.00
IUUC-Mpu-066199	Mustela putorius furo	91.97	0.00e+00	3464.00
IUUC-Mlu-067110	Myotis lucifugus	92.31	0.00e+00	3455.00
IUUC-Nfi-068482	Neosartorya fischeri	35.95	6.00e-115	409.00
IUUC-Ncr-068906	Neurospora crassa	35.07	8.00e-110	392.00
IUUC-Nle-069410	Nomascus leucogenys	94.25	0.00e+00	3196.00
IUUC-Opr-070401	Ochotona princeps	83.11	0.00e+00	1875.00
IUUC-Ont-072100	Oreochromis niloticus	83.29	0.00e+00	3171.00
IUUC-Oan-073121	Ornithorhynchus anatinus	94.72	0.00e+00	3637.00
IUUC-Ocu-074623	Oryctolagus cuniculus	92.02	0.00e+00	3511.00
IUUC-Oba-075380	Oryza barthii	36.81	8.00e-116	411.00
IUUC-Obr-076915	Oryza brachyantha	38.05	5.00e-121	429.00
IUUC-Ogl-077055	Oryza glaberrima	38.58	8.00e-120	425.00
IUUC-Ogu-078892	Oryza glumaepatula	40.57	4.00e-115	409.00
IUUC-Oin-079256	Oryza indica	38.26	2.00e-118	420.00
IUUC-Olo-080343	Oryza longistaminata	37.83	4.00e-118	419.00
IUUC-Ome-081422	Oryza meridionalis	37.83	3.00e-118	420.00
IUUC-Oni-083047	Oryza nivara	40.89	4.00e-116	412.00
IUUC-Opu-083641	Oryza punctata	36.44	2.00e-112	400.00
IUUC-Oru-084439	Oryza rufipogon	40.71	3.00e-115	409.00
IUUC-Osa-085972	Oryza sativa	38.58	4.00e-118	418.00
IUUC-Ola-087173	Oryzias latipes	81.59	0.00e+00	3083.00
IUUC-Olu-087871	Ostreococcus lucimarinus	37.67	4.00e-89	322.00
IUUC-Oga-087908	Otolemur garnettii	91.93	0.00e+00	3501.00
IUUC-Oar-090277	Ovis aries	91.39	0.00e+00	3472.00
IUUC-Ptr-091543	Pan troglodytes	94.03	0.00e+00	3209.00
IUUC-Pan-092243	Papio anubis	96.21	0.00e+00	3197.00
IUUC-Psi-093150	Pelodiscus sinensis	95.16	0.00e+00	3616.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.65	3.00e-115	410.00
IUUC-Ppa-095181	Physcomitrella patens	37.19	4.00e-107	382.00
IUUC-Pfo-096267	Poecilia formosa	88.64	0.00e+00	3054.00
IUUC-Pab-098072	Pongo abelii	94.58	0.00e+00	3207.00
IUUC-Pop-099190	Populus trichocarpa	37.14	4.00e-117	416.00
IUUC-Pca-100311	Procavia capensis	86.78	0.00e+00	3135.00
IUUC-Ppe-101284	Prunus persica	38.01	2.00e-117	417.00
IUUC-Pva-102215	Pteropus vampyrus	89.25	0.00e+00	1279.00
IUUC-Pgr-103694	Puccinia graminis	40.48	7.00e-105	375.00
IUUC-Ptt-103916	Puccinia triticina	38.80	6.00e-99	356.00
IUUC-Pte-104346	Pyrenophora teres	39.81	1.00e-111	398.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	40.07	3.00e-112	400.00
IUUC-Rno-105315	Rattus norvegicus	90.96	0.00e+00	3422.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.26	3.00e-71	264.00
IUUC-Sha-106835	Sarcophilus harrisii	95.12	0.00e+00	3646.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.98	4.00e-96	346.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.74	5.00e-96	346.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.32	1.00e-107	385.00
IUUC-Smo-109590	Selaginella moellendorffii	42.54	4.00e-111	396.00
IUUC-Sit-110717	Setaria italica	38.12	4.00e-121	429.00
IUUC-Sly-111469	Solanum lycopersicum	39.51	5.00e-123	436.00
IUUC-Stu-112896	Solanum tuberosum	38.23	1.00e-105	377.00
IUUC-Sar-113224	Sorex araneus	82.59	0.00e+00	1812.00
IUUC-Sbi-114313	Sorghum bicolor	38.29	2.00e-124	441.00
IUUC-Sre-114993	Sporisorium reilianum	32.95	7.00e-99	356.00
IUUC-Ssc-115535	Sus scrofa	88.67	0.00e+00	3338.00
IUUC-Tgu-117493	Taeniopygia guttata	97.64	0.00e+00	2897.00
IUUC-Tru-118669	Takifugu rubripes	81.26	0.00e+00	3042.00
IUUC-Tsy-119373	Tarsius syrichta	90.36	0.00e+00	1789.00
IUUC-Tni-120049	Tetraodon nigroviridis	78.72	0.00e+00	875.00
IUUC-Tca-121779	Theobroma cacao	38.90	2.00e-116	414.00
IUUC-Tre-122195	Trichoderma reesei	36.05	3.00e-107	384.00
IUUC-Tvi-122650	Trichoderma virens	36.08	1.00e-109	392.00
IUUC-Tae-123580	Triticum aestivum	38.73	5.00e-126	444.00
IUUC-Tur-126295	Triticum urartu	38.83	8.00e-128	452.00
IUUC-Tme-126964	Tuber melanosporum	40.48	7.00e-107	382.00
IUUC-Tbe-128149	Tupaia belangeri	78.45	0.00e+00	1407.00
IUUC-Ttr-128165	Tursiops truncatus	91.82	0.00e+00	2964.00
IUUC-Uma-129365	Ustilago maydis	35.36	3.00e-88	320.00
IUUC-Vda-129725	Verticillium dahliae	41.08	1.00e-109	391.00
IUUC-Vpa-130678	Vicugna pacos	93.59	0.00e+00	2593.00
IUUC-Vvi-131147	Vitis vinifera	39.83	4.00e-123	436.00
IUUC-Xtr-132636	Xenopus tropicalis	87.34	0.00e+00	3251.00
IUUC-Xma-133458	Xiphophorus maculatus	83.15	0.00e+00	3144.00
IUUC-Yli-134481	Yarrowia lipolytica	39.17	1.00e-97	351.00
IUUC-Zma-135657	Zea mays	38.47	7.00e-123	436.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence