iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012803

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 42; Deubiquitinating enzyme 42; Ubiquitin thioesterase 42; Ubiquitin-specific-processing protease 42

Genbank Nucleotide ID

AAFC03050082

Gene Name

USP42

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000000725.4	ENSBTAT00000000967.4	ENSBTAP00000000967.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-81	274.3	112	411

Active Site

Position(s)	Description	Evidence
120	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
371	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           Gl+NlgNtC+ N++LQcL+ +p+l++++l+ ++++++++     +  ++++++q  +++ +++   +++p  +++ ++++a++f+  +q
   Q: 112  GLQNLGNTCFANAALQCLTYTPPLANYMLShEHSKTCHA-----EGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQ 195
           9*****************************445555544.....578****************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da+Efl++ +d++++++                  l+ +++ + +++ ++l+ ++F+g l+s++kcl+c+ vs +++p ld++l+++ 
   Q: 196  EDAHEFLQYTVDAMQKAC------------------LNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKA 266
           ******************..................3344567789999**************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +     s++++Le+f+k+e+l+gen y+c+kckk + a+k++++++ ++vL+l LkRf    ++    ki k v++p+ Ld++p++++
   Q: 267  AQ-----SVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRF----ANFTGGKIAKDVKYPEYLDIRPYMSQ 346
           **.....9***************************************************....668889******************** PP
   S: 268  peekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           p+ +   + +Y L+av+vH+G +++ GHY++y+k ++g W++++Ds V++++  +vl+   ++aYvlfY r
   Q: 347  PNGE---PIIYVLYAVLVHTGfNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLS---QQAYVLFYIR 411
           9977...8**************************************************...********87 PP

Organism

Bos taurus

Functional Description
(View)

Deubiquitinating enzyme which may play an important role during spermatogenesis.

Protein Sequence
(Fasta)

MTIVDKASES SDPSTYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA 60
VVYSSSSVPE KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGTTGAA CAATGACCAT AGTTGACAAA GCTTCTGAAT CTTCAGACCC ATCAACCTAT 60
CAGAACCAGC CTGGCAGTTC TGAGGCTGTC TCACCTGGAG ACATGGATGC AGGTTCTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030154--P:cell differentiation
GO:0016579--P:protein deubiquitination
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000401	Aegilops tauschii	38.91	8.00e-71	262.00
IUUC-Aml-002303	Ailuropoda melanoleuca	74.08	0.00e+00	1440.00
IUUC-Atr-003102	Amborella trichopoda	46.91	3.00e-85	310.00
IUUC-Apl-003459	Anas platyrhynchos	55.64	0.00e+00	694.00
IUUC-Aca-004440	Anolis carolinensis	53.74	0.00e+00	972.00
IUUC-Ago-007836	Ashbya gossypii	26.18	4.00e-34	139.00
IUUC-Ame-011358	Astyanax mexicanus	66.18	0.00e+00	675.00
IUUC-Cja-019199	Callithrix jacchus	71.18	0.00e+00	1533.00
IUUC-Cfa-020597	Canis familiaris	76.69	0.00e+00	1678.00
IUUC-Cpo-021945	Cavia porcellus	67.44	0.00e+00	1533.00
IUUC-Csa-023485	Chlorocebus sabaeus	75.39	0.00e+00	1272.00
IUUC-Cho-024575	Choloepus hoffmanni	73.62	0.00e+00	986.00
IUUC-Cne-027049	Cryptococcus neoformans	31.86	6.00e-38	152.00
IUUC-Dre-028442	Danio rerio	64.78	0.00e+00	660.00
IUUC-Dno-029673	Dasypus novemcinctus	73.28	0.00e+00	1746.00
IUUC-Dor-030518	Dipodomys ordii	62.05	7.00e-121	428.00
IUUC-Ete-033088	Echinops telfairi	59.05	0.00e+00	945.00
IUUC-Eca-033579	Equus caballus	75.45	0.00e+00	1672.00
IUUC-Eeu-034511	Erinaceus europaeus	53.87	0.00e+00	928.00
IUUC-Fca-035792	Felis catus	74.33	0.00e+00	1591.00
IUUC-Fal-037075	Ficedula albicollis	55.96	0.00e+00	753.00
IUUC-Gga-040504	Gallus gallus	42.44	0.00e+00	749.00
IUUC-Ggo-044798	Gorilla gorilla	69.39	0.00e+00	1059.00
IUUC-Hsa-046072	Homo sapiens	76.53	0.00e+00	1292.00
IUUC-Hvu-047620	Hordeum vulgare	41.25	7.00e-74	272.00
IUUC-Itr-048078	Ictidomys tridecemlineatus	74.22	0.00e+00	1754.00
IUUC-Lch-049867	Latimeria chalumnae	68.74	0.00e+00	954.00
IUUC-Loc-052621	Lepisosteus oculatus	64.08	0.00e+00	703.00
IUUC-Laf-054330	Loxodonta africana	89.50	0.00e+00	1246.00
IUUC-Mcc-054900	Macaca mulatta	94.92	0.00e+00	767.00
IUUC-Meu-056877	Macropus eugenii	47.62	1.00e-177	617.00
IUUC-Mga-059501	Meleagris gallopavo	39.43	0.00e+00	682.00
IUUC-Mvi-060547	Microbotryum violaceum	45.62	1.00e-80	294.00
IUUC-Mmr-060864	Microcebus murinus	73.69	0.00e+00	1744.00
IUUC-Mdo-062395	Monodelphis domestica	60.44	0.00e+00	1450.00
IUUC-Mmu-064236	Mus musculus	66.84	0.00e+00	1474.00
IUUC-Mpu-065822	Mustela putorius furo	76.78	0.00e+00	1722.00
IUUC-Mlu-067091	Myotis lucifugus	73.92	0.00e+00	1611.00
IUUC-Nle-069004	Nomascus leucogenys	70.46	0.00e+00	1515.00
IUUC-Opr-071170	Ochotona princeps	61.53	0.00e+00	1080.00
IUUC-Ont-071832	Oreochromis niloticus	61.14	0.00e+00	649.00
IUUC-Oan-073711	Ornithorhynchus anatinus	55.90	0.00e+00	1211.00
IUUC-Ocu-074596	Oryctolagus cuniculus	94.39	0.00e+00	1035.00
IUUC-Oga-088641	Otolemur garnettii	71.74	0.00e+00	1669.00
IUUC-Oar-089760	Ovis aries	91.63	0.00e+00	2104.00
IUUC-Ptr-091445	Pan troglodytes	76.01	0.00e+00	1282.00
IUUC-Pan-092484	Papio anubis	88.81	0.00e+00	1216.00
IUUC-Psi-093277	Pelodiscus sinensis	53.58	0.00e+00	1088.00
IUUC-Pma-094651	Petromyzon marinus	38.24	2.00e-56	212.00
IUUC-Pfo-096469	Poecilia formosa	66.67	0.00e+00	652.00
IUUC-Pab-097794	Pongo abelii	74.04	0.00e+00	1150.00
IUUC-Ppe-101678	Prunus persica	46.25	4.00e-82	299.00
IUUC-Pva-103238	Pteropus vampyrus	71.06	0.00e+00	1494.00
IUUC-Rno-105068	Rattus norvegicus	67.06	0.00e+00	1479.00
IUUC-Sha-106713	Sarcophilus harrisii	61.73	0.00e+00	1485.00
IUUC-Smo-108763	Selaginella moellendorffii	47.73	2.00e-80	292.00
IUUC-Sly-111722	Solanum lycopersicum	44.65	3.00e-78	286.00
IUUC-Sar-113340	Sorex araneus	84.45	0.00e+00	1100.00
IUUC-Tgu-117149	Taeniopygia guttata	57.06	0.00e+00	760.00
IUUC-Tru-117776	Takifugu rubripes	65.42	3.00e-176	612.00
IUUC-Tsy-118974	Tarsius syrichta	70.92	0.00e+00	1618.00
IUUC-Tni-120774	Tetraodon nigroviridis	68.44	4.00e-174	604.00
IUUC-Tca-120936	Theobroma cacao	45.93	3.00e-84	306.00
IUUC-Tbe-128006	Tupaia belangeri	86.04	3.00e-122	433.00
IUUC-Ttr-128764	Tursiops truncatus	74.85	0.00e+00	1627.00
IUUC-Vvi-131535	Vitis vinifera	46.35	9.00e-87	315.00
IUUC-Xtr-132544	Xenopus tropicalis	57.69	0.00e+00	646.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence