iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044430

UUCD1 version

UUC-GoG-00518

Ensembl Protein ID

ENSGGOP00000013129.2

UniProt Accession

G3RCA5; G3RCA5_GORGO

Protein Name

Uncharacterized protein

Gene Name

RFWD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000013437.2	ENSGGOT00000013507.2	ENSGGOP00000013129.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.10e-07	30.1	103	141
E3 adaptor/Cullin RING/DCX/DWD	1.20e-10	41.6	481	511

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++++  + + CgH f+ +C+++          + rCP C+
   Q: 103  CPICFDMIEE-AYMTKCGHSFCYKCIHQS------LEDNNRCPKCN 141
           ********99.888***********9555......999999****7 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf....sdtllvsGsdDgtikvWD 29
           H+ + ++++f    + +ll+sGsdD ++k+W+
   Q: 481  HEKRCWSVDFnlmdP-KLLASGSDDAKVKLWS 511
           777889999999633.99*************9 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MSGSRQAGSG SAGTSPGSSA ASSVTSASSS LSSSPSPPSV AVSAAALVSG GVAQAAGSGG 60
LGGPVRPVLV APAVSGSRKR PLLAPLCNGL INSYEDKSND FVCPICFDMI EEAYMTKCGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGGTA GCCGCCAGGC CGGGTCGGGC TCCGCTGGGA CAAGCCCTGG CTCCTCGGCG 60
GCCTCCTCGG TGACTTCCGC CTCCTCGTCT TTATCCTCTT CCCCGTCGCC GCCTTCCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00400--WD40

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000885	Aegilops tauschii	36.17	2.00e-79	290.00
IUUC-Aml-001265	Ailuropoda melanoleuca	98.74	0.00e+00	941.00
IUUC-Atr-002460	Amborella trichopoda	35.01	2.00e-80	293.00
IUUC-Apl-003796	Anas platyrhynchos	97.53	0.00e+00	870.00
IUUC-Aca-005078	Anolis carolinensis	95.97	0.00e+00	894.00
IUUC-Aly-006014	Arabidopsis lyrata	36.40	8.00e-83	301.00
IUUC-Ath-007636	Arabidopsis thaliana	36.20	3.00e-82	299.00
IUUC-Ame-011176	Astyanax mexicanus	75.81	7.00e-70	258.00
IUUC-Bta-012595	Bos taurus	90.99	0.00e+00	934.00
IUUC-Bdi-014152	Brachypodium distachyon	35.87	4.00e-84	305.00
IUUC-Bol-016380	Brassica oleracea	36.09	2.00e-82	300.00
IUUC-Bra-017690	Brassica rapa	35.04	3.00e-77	283.00
IUUC-Cja-018926	Callithrix jacchus	98.31	0.00e+00	928.00
IUUC-Cfa-021088	Canis familiaris	98.09	0.00e+00	929.00
IUUC-Cpo-022442	Cavia porcellus	97.89	0.00e+00	926.00
IUUC-Cre-022579	Chlamydomonas reinhardtii	31.76	8.00e-17	80.50
IUUC-Csa-024119	Chlorocebus sabaeus	98.73	0.00e+00	934.00
IUUC-Cho-024883	Choloepus hoffmanni	86.43	7.00e-103	368.00
IUUC-Cin-025375	Ciona intestinalis	50.00	5.00e-129	454.00
IUUC-Cme-027350	Cyanidioschyzon merolae	42.78	2.00e-41	164.00
IUUC-Dre-028453	Danio rerio	84.41	0.00e+00	775.00
IUUC-Dno-029887	Dasypus novemcinctus	97.46	0.00e+00	922.00
IUUC-Dor-031110	Dipodomys ordii	84.45	9.00e-160	556.00
IUUC-Dse-031398	Dothistroma septosporum	38.10	3.00e-08	53.50
IUUC-Ete-033016	Echinops telfairi	78.60	0.00e+00	713.00
IUUC-Eca-034403	Equus caballus	98.21	0.00e+00	874.00
IUUC-Eeu-034690	Erinaceus europaeus	78.48	0.00e+00	674.00
IUUC-Fca-036475	Felis catus	97.98	0.00e+00	874.00
IUUC-Fal-037189	Ficedula albicollis	97.32	0.00e+00	872.00
IUUC-Gmo-039245	Gadus morhua	83.58	0.00e+00	756.00
IUUC-Gga-040806	Gallus gallus	97.03	0.00e+00	920.00
IUUC-Gac-042177	Gasterosteus aculeatus	83.43	0.00e+00	801.00
IUUC-Gma-044187	Glycine max	35.57	3.00e-79	289.00
IUUC-Hsa-045853	Homo sapiens	99.15	0.00e+00	942.00
IUUC-Hvu-047750	Hordeum vulgare	36.63	3.00e-52	201.00
IUUC-Itr-048238	Ictidomys tridecemlineatus	98.07	1.00e-118	418.00
IUUC-Kpa-049242	Komagataella pastoris	58.62	2.00e-07	48.50
IUUC-Lch-050420	Latimeria chalumnae	89.77	0.00e+00	841.00
IUUC-Lpe-051219	Leersia perrieri	35.33	3.00e-82	299.00
IUUC-Loc-052728	Lepisosteus oculatus	89.60	0.00e+00	800.00
IUUC-Laf-053775	Loxodonta africana	97.67	0.00e+00	936.00
IUUC-Meu-056595	Macropus eugenii	74.74	2.00e-151	529.00
IUUC-Mtr-058555	Medicago truncatula	35.93	5.00e-88	318.00
IUUC-Mga-059646	Meleagris gallopavo	96.88	0.00e+00	870.00
IUUC-Mmr-060990	Microcebus murinus	98.73	0.00e+00	936.00
IUUC-Mdo-062287	Monodelphis domestica	97.88	0.00e+00	930.00
IUUC-Mmu-064097	Mus musculus	98.09	0.00e+00	932.00
IUUC-Mac-065240	Musa acuminata	35.95	7.00e-87	315.00
IUUC-Mpu-066612	Mustela putorius furo	98.43	0.00e+00	879.00
IUUC-Mlu-067967	Myotis lucifugus	97.99	0.00e+00	874.00
IUUC-Nle-069543	Nomascus leucogenys	98.52	0.00e+00	933.00
IUUC-Opr-070366	Ochotona princeps	83.33	0.00e+00	713.00
IUUC-Ont-071522	Oreochromis niloticus	80.12	0.00e+00	794.00
IUUC-Oan-073409	Ornithorhynchus anatinus	98.21	0.00e+00	873.00
IUUC-Ocu-073756	Oryctolagus cuniculus	97.88	0.00e+00	932.00
IUUC-Oba-075149	Oryza barthii	35.40	1.00e-82	301.00
IUUC-Obr-076563	Oryza brachyantha	35.27	1.00e-82	300.00
IUUC-Ogl-077701	Oryza glaberrima	35.40	5.00e-83	302.00
IUUC-Ogu-078383	Oryza glumaepatula	35.40	5.00e-83	302.00
IUUC-Oin-079965	Oryza indica	32.62	1.00e-68	254.00
IUUC-Olo-080639	Oryza longistaminata	34.70	4.00e-80	292.00
IUUC-Ome-081821	Oryza meridionalis	34.63	8.00e-71	261.00
IUUC-Oni-082622	Oryza nivara	35.40	5.00e-83	302.00
IUUC-Opu-083295	Oryza punctata	35.00	8.00e-83	301.00
IUUC-Oru-084661	Oryza rufipogon	35.40	5.00e-83	302.00
IUUC-Osa-085766	Oryza sativa	35.40	5.00e-83	302.00
IUUC-Ola-086727	Oryzias latipes	82.63	0.00e+00	804.00
IUUC-Olu-087702	Ostreococcus lucimarinus	40.51	6.00e-30	124.00
IUUC-Oga-088215	Otolemur garnettii	98.73	0.00e+00	934.00
IUUC-Oar-089880	Ovis aries	98.73	0.00e+00	934.00
IUUC-Ptr-090597	Pan troglodytes	99.15	0.00e+00	942.00
IUUC-Pan-091987	Papio anubis	98.73	0.00e+00	934.00
IUUC-Psi-094033	Pelodiscus sinensis	96.60	0.00e+00	848.00
IUUC-Pma-094587	Petromyzon marinus	66.46	0.00e+00	650.00
IUUC-Ppa-095256	Physcomitrella patens	35.74	3.00e-84	306.00
IUUC-Pfo-097388	Poecilia formosa	83.30	0.00e+00	765.00
IUUC-Pab-098029	Pongo abelii	99.15	0.00e+00	942.00
IUUC-Pop-099319	Populus trichocarpa	35.61	2.00e-83	303.00
IUUC-Pca-100846	Procavia capensis	87.08	0.00e+00	821.00
IUUC-Ppe-101250	Prunus persica	33.14	1.00e-73	270.00
IUUC-Pva-102407	Pteropus vampyrus	98.31	0.00e+00	920.00
IUUC-Rno-105312	Rattus norvegicus	98.09	0.00e+00	931.00
IUUC-Sha-106514	Sarcophilus harrisii	97.51	1.00e-139	489.00
IUUC-Smo-109418	Selaginella moellendorffii	35.67	5.00e-82	298.00
IUUC-Sit-110248	Setaria italica	35.08	1.00e-83	303.00
IUUC-Sly-110964	Solanum lycopersicum	37.75	2.00e-84	306.00
IUUC-Stu-112882	Solanum tuberosum	38.08	6.00e-86	311.00
IUUC-Sar-113230	Sorex araneus	71.52	9.00e-173	600.00
IUUC-Sbi-113962	Sorghum bicolor	33.33	3.00e-79	289.00
IUUC-Ssc-115987	Sus scrofa	98.42	4.00e-176	610.00
IUUC-Tgu-116471	Taeniopygia guttata	97.25	0.00e+00	922.00
IUUC-Tru-118231	Takifugu rubripes	79.88	0.00e+00	741.00
IUUC-Tsy-119415	Tarsius syrichta	97.31	0.00e+00	851.00
IUUC-Tni-120893	Tetraodon nigroviridis	83.97	0.00e+00	751.00
IUUC-Tca-121703	Theobroma cacao	37.83	4.00e-81	295.00
IUUC-Tae-125440	Triticum aestivum	37.15	6.00e-86	311.00
IUUC-Tur-126557	Triticum urartu	36.40	1.00e-81	296.00
IUUC-Tbe-127253	Tupaia belangeri	69.92	0.00e+00	635.00
IUUC-Ttr-129100	Tursiops truncatus	98.65	0.00e+00	880.00
IUUC-Vpa-130613	Vicugna pacos	98.87	0.00e+00	874.00
IUUC-Vvi-130880	Vitis vinifera	36.81	2.00e-76	280.00
IUUC-Xtr-132033	Xenopus tropicalis	90.46	0.00e+00	936.00
IUUC-Xma-133421	Xiphophorus maculatus	80.20	0.00e+00	763.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence