iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028603

UUCD1 version

UUC-DaR-00230

Ensembl Protein ID

ENSDARP00000057021.5

UniProt Accession

B3DIV9; B8JL77; Q66L56; KL40A_DANRE

Genbank Protein ID

AAH78427.1; AAI63267.1

Protein Name

Kelch-like protein 40a; Kelch repeat and BTB domain-containing protein 5a

Genbank Nucleotide ID

CU464125; BC163267

Gene Name

klhl40a; kbtbd5a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000039052.6	ENSDART00000057022.6	ENSDARP00000057021.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.70e-23	83.0	35	100
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.80e-10	37.9	133	161

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           D+il+++++ef++h++vLaa S++F+a+fl++leesk k ++++kd++p+v+  +l+++Yt+ ++++
   Q: 35   DCILKIKDKEFPCHRLVLAATSPYFKAMFLSDLEESK-KREIVLKDIEPGVMGMILRYIYTSDINLT 100
           9************************************.***********************999876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilk 29
           l+Ncl+i+r++ l+dcp+L+  a+dfi++
   Q: 133  LSNCLAIFRLGLLLDCPRLAMEARDFICD 161
           69*************************98 PP

Organism

Danio rerio

Functional Description
(View)

ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development (PubMed:23746549).

Protein Sequence
(Fasta)

MASMSVDPVT EPRMYQQTLL QDGLCDLLDA NKFVDCILKI KDKEFPCHRL VLAATSPYFK 60
AMFLSDLEES KKREIVLKDI EPGVMGMILR YIYTSDINLT EQNVQDIFMA ANMYQIPSIF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCCCTCC TGCTGGAATA CCACCTCAAT CCATAACAAG ATGGCCTCCA TGTCAGTGGA 60
CCCGGTGACG GAGCCACGGA TGTACCAGCA AACGCTCCTA CAAGATGGAC TCTGTGATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031672--C:A band
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031674--C:I band
GO:0061061--P:muscle structure development
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016567--P:protein ubiquitination
GO:0048741--P:skeletal muscle fiber development
GO:0036268--P:swimming

KEGG

dre:553257

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001792	Ailuropoda melanoleuca	54.15	0.00e+00	684.00
IUUC-Apl-003748	Anas platyrhynchos	64.08	0.00e+00	805.00
IUUC-Aca-005275	Anolis carolinensis	57.26	0.00e+00	708.00
IUUC-Ame-011211	Astyanax mexicanus	80.13	0.00e+00	1003.00
IUUC-Bta-012801	Bos taurus	57.99	0.00e+00	749.00
IUUC-Bdi-014779	Brachypodium distachyon	28.93	6.00e-15	76.60
IUUC-Cja-019795	Callithrix jacchus	56.92	0.00e+00	669.00
IUUC-Cpo-022436	Cavia porcellus	58.63	0.00e+00	759.00
IUUC-Csa-023105	Chlorocebus sabaeus	58.11	0.00e+00	733.00
IUUC-Eca-034393	Equus caballus	57.31	0.00e+00	705.00
IUUC-Fca-035823	Felis catus	49.53	1.00e-178	619.00
IUUC-Fal-037632	Ficedula albicollis	65.32	0.00e+00	793.00
IUUC-Gmo-038524	Gadus morhua	72.06	0.00e+00	826.00
IUUC-Gga-040525	Gallus gallus	64.40	0.00e+00	806.00
IUUC-Gac-042244	Gasterosteus aculeatus	72.91	0.00e+00	868.00
IUUC-Ggo-045596	Gorilla gorilla	58.43	0.00e+00	736.00
IUUC-Hsa-046235	Homo sapiens	58.11	0.00e+00	729.00
IUUC-Itr-048612	Ictidomys tridecemlineatus	58.24	0.00e+00	755.00
IUUC-Lch-050123	Latimeria chalumnae	64.37	0.00e+00	826.00
IUUC-Loc-051824	Lepisosteus oculatus	69.00	0.00e+00	893.00
IUUC-Mcc-054909	Macaca mulatta	57.95	0.00e+00	732.00
IUUC-Meu-055972	Macropus eugenii	59.07	0.00e+00	748.00
IUUC-Mga-059451	Meleagris gallopavo	64.24	0.00e+00	806.00
IUUC-Mmr-060736	Microcebus murinus	58.29	0.00e+00	747.00
IUUC-Mmu-063549	Mus musculus	57.96	0.00e+00	747.00
IUUC-Mpu-066262	Mustela putorius furo	58.47	0.00e+00	759.00
IUUC-Mlu-067210	Myotis lucifugus	57.76	0.00e+00	748.00
IUUC-Opr-070384	Ochotona princeps	55.36	0.00e+00	684.00
IUUC-Ont-071959	Oreochromis niloticus	76.80	0.00e+00	944.00
IUUC-Ocu-074499	Oryctolagus cuniculus	57.87	0.00e+00	733.00
IUUC-Ola-087484	Oryzias latipes	75.65	0.00e+00	974.00
IUUC-Oga-088855	Otolemur garnettii	57.81	0.00e+00	751.00
IUUC-Ptr-091028	Pan troglodytes	54.57	6.00e-138	484.00
IUUC-Pan-091827	Papio anubis	58.11	0.00e+00	733.00
IUUC-Psi-092998	Pelodiscus sinensis	63.49	0.00e+00	788.00
IUUC-Pma-094586	Petromyzon marinus	61.86	1.00e-89	322.00
IUUC-Pfo-097468	Poecilia formosa	74.88	0.00e+00	947.00
IUUC-Rno-105613	Rattus norvegicus	57.19	0.00e+00	660.00
IUUC-Sha-107091	Sarcophilus harrisii	60.31	0.00e+00	787.00
IUUC-Ssc-116276	Sus scrofa	57.67	0.00e+00	748.00
IUUC-Tgu-116494	Taeniopygia guttata	64.89	0.00e+00	819.00
IUUC-Tru-118457	Takifugu rubripes	74.51	0.00e+00	939.00
IUUC-Tni-120080	Tetraodon nigroviridis	74.35	0.00e+00	947.00
IUUC-Tbe-127806	Tupaia belangeri	53.37	0.00e+00	672.00
IUUC-Ttr-128813	Tursiops truncatus	57.42	0.00e+00	739.00
IUUC-Xtr-132942	Xenopus tropicalis	65.18	0.00e+00	801.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence