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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064339
UUCD1 version UUC-MuM-00455
Ensembl Protein ID ENSMUSP00000105493.1
UniProt Accession Q5SSZ7; B2RXA5; Q3V095; ZNRF3_MOUSE
Genbank Protein ID BAE21609.1; CAI24933.1; CAI24933.1; CAI24978.1; CAI24978.1; AAI51081.1; AAI51084.1
Protein Name E3 ubiquitin-protein ligase ZNRF3; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3
Genbank Nucleotide ID AK133342; AL662876; AL662853; AL662853; AL662876; BC151080; BC151083
Gene Name Znrf3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000041961.14 ENSMUST00000109867.7 ENSMUSP00000105493.1
ENSMUSG00000041961.14 ENSMUST00000172492.7 ENSMUSP00000134698.1
ENSMUSG00000041961.14 ENSMUST00000143746.2 ENSMUSP00000122475.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 85.00 0.00e+00 1314.00 IUUC-Hsa-046484
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Protein Sequence
(Fasta)
MRPRSGGRPG APGRRRRRLR RGPRGRRLPP PPPLPLLLGL LLAAAGPGAA RAKETAFVEV 60
VLFESSPSGD YTTHTTGLTG RFSRAGAMLS AEGEIVQMHP LGLCNNNDEE DLYEYGWVGV 120
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Protein Fasta Sequence


>IUUC-Mmu-064339|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGATGAAAGG GCCGCGGCGC GACGGCCGGG GGAGCGGAGC AGAGCCTGCG ACCCACAAAG 60
CCGCCGCCGC CGCGATGGTG CTGTGAGGCG ACCGCCCGCG CTCGGTCCTC CGCCGGCCCG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064339|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005109--F:frizzled binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0016567--P:protein ubiquitination
GO:0072089--P:stem cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0038018--P:Wnt receptor catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway
KEGG mmu:407821
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001916 Ailuropoda melanoleuca 80.17 0.00e+00 1162.00
IUUC-Atr-002558 Amborella trichopoda 33.61 2.00e-12 67.00
IUUC-Apl-004188 Anas platyrhynchos 71.98 0.00e+00 997.00
IUUC-Aca-004606 Anolis carolinensis 36.07 4.00e-27 115.00
IUUC-Aly-005850 Arabidopsis lyrata 42.68 1.00e-15 75.90
IUUC-Ath-007372 Arabidopsis thaliana 42.17 2.00e-15 75.10
IUUC-Ame-011764 Astyanax mexicanus 62.96 0.00e+00 734.00
IUUC-Bta-012478 Bos taurus 61.01 1.00e-175 610.00
IUUC-Bol-016217 Brassica oleracea 42.35 4.00e-15 73.90
IUUC-Bra-017407 Brassica rapa 42.35 4.00e-15 73.90
IUUC-Cja-019504 Callithrix jacchus 85.71 0.00e+00 1286.00
IUUC-Cfa-020048 Canis familiaris 82.40 0.00e+00 1228.00
IUUC-Cpo-021725 Cavia porcellus 83.41 0.00e+00 1264.00
IUUC-Csa-023586 Chlorocebus sabaeus 83.90 0.00e+00 1225.00
IUUC-Cho-024867 Choloepus hoffmanni 91.18 0.00e+00 691.00
IUUC-Cin-025569 Ciona intestinalis 47.74 9.00e-57 214.00
IUUC-Csv-025869 Ciona savignyi 45.49 5.00e-60 225.00
IUUC-Dre-027553 Danio rerio 65.82 0.00e+00 874.00
IUUC-Dno-029370 Dasypus novemcinctus 80.32 0.00e+00 1143.00
IUUC-Dor-030816 Dipodomys ordii 78.02 0.00e+00 1102.00
IUUC-Ete-033060 Echinops telfairi 71.43 0.00e+00 810.00
IUUC-Eca-034044 Equus caballus 83.15 0.00e+00 1231.00
IUUC-Eeu-034591 Erinaceus europaeus 64.54 3.00e-133 469.00
IUUC-Fca-036000 Felis catus 83.19 0.00e+00 1241.00
IUUC-Fal-037147 Ficedula albicollis 71.07 0.00e+00 994.00
IUUC-Fox-037731 Fusarium oxysporum 39.33 8.00e-13 67.00
IUUC-Gmo-039099 Gadus morhua 60.35 3.00e-112 399.00
IUUC-Ggr-039947 Gaeumannomyces graminis 30.43 6.00e-12 65.90
IUUC-Gga-041243 Gallus gallus 68.36 0.00e+00 783.00
IUUC-Gac-041340 Gasterosteus aculeatus 49.40 1.00e-116 413.00
IUUC-Gma-044387 Glycine max 49.23 6.00e-17 80.50
IUUC-Ggo-044953 Gorilla gorilla 84.91 0.00e+00 1262.00
IUUC-Hsa-046484 Homo sapiens 85.55 0.00e+00 1332.00
IUUC-Hvu-047249 Hordeum vulgare 44.44 3.00e-14 70.90
IUUC-Itr-048470 Ictidomys tridecemlineatus 85.44 0.00e+00 1261.00
IUUC-Lch-050004 Latimeria chalumnae 57.81 0.00e+00 656.00
IUUC-Lpe-051375 Leersia perrieri 53.06 7.00e-13 68.20
IUUC-Loc-051830 Lepisosteus oculatus 65.82 0.00e+00 868.00
IUUC-Laf-053975 Loxodonta africana 83.37 0.00e+00 1224.00
IUUC-Mcc-055302 Macaca mulatta 83.54 0.00e+00 1204.00
IUUC-Meu-056263 Macropus eugenii 74.69 0.00e+00 790.00
IUUC-Mtr-058744 Medicago truncatula 39.60 5.00e-15 73.90
IUUC-Mga-059706 Meleagris gallopavo 71.98 0.00e+00 1022.00
IUUC-Mmr-061372 Microcebus murinus 79.57 0.00e+00 1199.00
IUUC-Mdo-062651 Monodelphis domestica 69.56 0.00e+00 874.00
IUUC-Mac-065574 Musa acuminata 45.45 1.00e-14 72.40
IUUC-Mpu-066211 Mustela putorius furo 80.96 0.00e+00 1187.00
IUUC-Mlu-067058 Myotis lucifugus 83.27 0.00e+00 1159.00
IUUC-Nle-069886 Nomascus leucogenys 84.26 0.00e+00 1247.00
IUUC-Opr-070218 Ochotona princeps 78.56 0.00e+00 1050.00
IUUC-Ont-072483 Oreochromis niloticus 62.75 0.00e+00 847.00
IUUC-Oan-073718 Ornithorhynchus anatinus 70.94 0.00e+00 924.00
IUUC-Ocu-073847 Oryctolagus cuniculus 75.03 0.00e+00 1024.00
IUUC-Oba-075508 Oryza barthii 53.06 7.00e-13 68.20
IUUC-Obr-076466 Oryza brachyantha 43.66 1.00e-13 69.30
IUUC-Ogl-077079 Oryza glaberrima 53.06 7.00e-13 68.20
IUUC-Ogu-078315 Oryza glumaepatula 53.06 6.00e-13 68.60
IUUC-Oin-079821 Oryza indica 53.06 7.00e-13 68.20
IUUC-Olo-080552 Oryza longistaminata 32.50 3.00e-13 69.30
IUUC-Oni-082586 Oryza nivara 53.06 7.00e-13 68.20
IUUC-Opu-083306 Oryza punctata 63.83 4.00e-13 67.80
IUUC-Oru-084696 Oryza rufipogon 53.06 6.00e-13 68.60
IUUC-Osa-086259 Oryza sativa 53.06 6.00e-13 68.60
IUUC-Ola-087358 Oryzias latipes 62.53 0.00e+00 759.00
IUUC-Oga-088362 Otolemur garnettii 83.33 0.00e+00 1263.00
IUUC-Oar-090197 Ovis aries 98.48 2.00e-96 347.00
IUUC-Ptr-091350 Pan troglodytes 85.43 0.00e+00 1329.00
IUUC-Pan-091700 Papio anubis 83.93 0.00e+00 1259.00
IUUC-Psi-093301 Pelodiscus sinensis 70.50 0.00e+00 955.00
IUUC-Ppa-095409 Physcomitrella patens 42.25 3.00e-13 69.70
IUUC-Pfo-096917 Poecilia formosa 63.45 0.00e+00 770.00
IUUC-Pab-097932 Pongo abelii 84.18 0.00e+00 1270.00
IUUC-Pop-099512 Populus trichocarpa 49.18 1.00e-15 75.90
IUUC-Pca-101054 Procavia capensis 90.10 0.00e+00 938.00
IUUC-Ppe-102030 Prunus persica 33.85 1.00e-14 74.30
IUUC-Pva-102879 Pteropus vampyrus 83.17 0.00e+00 1237.00
IUUC-Pgr-103645 Puccinia graminis 40.24 1.00e-10 60.10
IUUC-Sha-106507 Sarcophilus harrisii 53.61 2.00e-160 559.00
IUUC-Sit-109802 Setaria italica 53.06 3.00e-13 69.70
IUUC-Sly-111371 Solanum lycopersicum 36.04 5.00e-14 70.90
IUUC-Stu-112010 Solanum tuberosum 47.95 7.00e-14 71.60
IUUC-Sar-113182 Sorex araneus 86.72 1.00e-110 394.00
IUUC-Sbi-114294 Sorghum bicolor 53.06 4.00e-13 68.90
IUUC-Ssc-115966 Sus scrofa 77.02 0.00e+00 1029.00
IUUC-Tgu-116864 Taeniopygia guttata 62.82 0.00e+00 630.00
IUUC-Tru-118502 Takifugu rubripes 62.95 0.00e+00 811.00
IUUC-Tsy-119210 Tarsius syrichta 84.75 0.00e+00 1226.00
IUUC-Tni-120344 Tetraodon nigroviridis 53.62 3.00e-128 452.00
IUUC-Tca-121005 Theobroma cacao 40.00 8.00e-15 73.60
IUUC-Tbe-127735 Tupaia belangeri 80.86 2.00e-128 452.00
IUUC-Ttr-128714 Tursiops truncatus 71.46 0.00e+00 933.00
IUUC-Vvi-131280 Vitis vinifera 31.50 5.00e-15 75.50
IUUC-Xtr-132280 Xenopus tropicalis 61.46 0.00e+00 780.00
Created Date 25-Jun-2017

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