iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055716

Ensembl Protein ID

ENSMMUP00000041599.1

UniProt Accession

G7NRP9; G7NRP9_MACMU

Genbank Protein ID

AFH34719.1; AFH34720.1; EHH31126.1

Protein Name

Rho guanine nucleotide exchange factor 6

Genbank Nucleotide ID

JSUE03046877; JU477916; CM001273

Gene Name

ARHGEF6; EGK_20986

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000013768.3	ENSMMUT00000065490.1	ENSMMUP00000041599.1
ENSMMUG00000013768.3	ENSMMUT00000019339.3	ENSMMUP00000018110.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.80e-14	53.2	164	218

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++ ++++ +n+deL+  kGd+++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 164  IVKARFNFKQTNEDELSVCKGDIIYVT--RVEEGGWWEG--TLNGRTGWFPSNYVREIK 218
           68999*********************7..999*******..8**************997 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MNPEEQIVTW LISLGVLDSP KKTICDPEEF LKSSLKNGVV LCKLINRLMP GSVEKFCLDP 60
QTEADCINNI NDFLKGCATL QVEVFDPDDL YSGVNFSKVL STLLAVNKAT EDQLSERPCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAAAAAGGA AGACAACAGC AGATGCAATC GCGGATGTGG CTTAGTCCTT GCAGCTGCCC 60
CAGAGTGCTG TTTGGAGTGT ACTGTCCTCA GTAATGAATC CAGAAGAACA AATCGTGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

KEGG

mcc:693976

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001631	Ailuropoda melanoleuca	79.47	0.00e+00	1265.00
IUUC-Apl-003960	Anas platyrhynchos	75.26	0.00e+00	1126.00
IUUC-Aca-004988	Anolis carolinensis	70.31	0.00e+00	1048.00
IUUC-Ame-011546	Astyanax mexicanus	63.26	0.00e+00	956.00
IUUC-Bta-013527	Bos taurus	94.46	0.00e+00	1414.00
IUUC-Cja-018935	Callithrix jacchus	98.07	0.00e+00	1455.00
IUUC-Cfa-021269	Canis familiaris	93.94	0.00e+00	1399.00
IUUC-Cpo-021620	Cavia porcellus	88.22	0.00e+00	1310.00
IUUC-Csa-023415	Chlorocebus sabaeus	99.87	0.00e+00	1480.00
IUUC-Dre-028580	Danio rerio	63.40	0.00e+00	969.00
IUUC-Dno-029201	Dasypus novemcinctus	90.01	0.00e+00	1371.00
IUUC-Dor-030868	Dipodomys ordii	75.52	0.00e+00	1036.00
IUUC-Eca-033500	Equus caballus	94.59	0.00e+00	1392.00
IUUC-Eeu-035269	Erinaceus europaeus	81.03	7.00e-164	570.00
IUUC-Fca-035683	Felis catus	93.94	0.00e+00	1373.00
IUUC-Fal-037611	Ficedula albicollis	75.52	0.00e+00	1127.00
IUUC-Gmo-038980	Gadus morhua	61.51	0.00e+00	924.00
IUUC-Gga-040940	Gallus gallus	74.32	0.00e+00	1124.00
IUUC-Gac-042203	Gasterosteus aculeatus	60.26	0.00e+00	940.00
IUUC-Ggo-044755	Gorilla gorilla	99.10	0.00e+00	1469.00
IUUC-Hsa-046210	Homo sapiens	98.58	0.00e+00	1465.00
IUUC-Lch-049517	Latimeria chalumnae	69.03	0.00e+00	1040.00
IUUC-Loc-052393	Lepisosteus oculatus	63.98	0.00e+00	1015.00
IUUC-Laf-054196	Loxodonta africana	92.52	0.00e+00	1336.00
IUUC-Meu-056285	Macropus eugenii	72.08	0.00e+00	668.00
IUUC-Mtr-058576	Medicago truncatula	44.62	4.00e-11	62.40
IUUC-Mga-060029	Meleagris gallopavo	75.00	0.00e+00	1142.00
IUUC-Mmr-060803	Microcebus murinus	94.85	0.00e+00	1403.00
IUUC-Mdo-062654	Monodelphis domestica	78.92	0.00e+00	1211.00
IUUC-Mmu-063479	Mus musculus	91.10	0.00e+00	1329.00
IUUC-Mpu-066065	Mustela putorius furo	93.30	0.00e+00	1365.00
IUUC-Mlu-068222	Myotis lucifugus	93.18	0.00e+00	1356.00
IUUC-Nle-069379	Nomascus leucogenys	99.10	0.00e+00	1469.00
IUUC-Opr-070687	Ochotona princeps	73.87	0.00e+00	826.00
IUUC-Ont-072240	Oreochromis niloticus	58.76	0.00e+00	915.00
IUUC-Oan-073067	Ornithorhynchus anatinus	80.54	0.00e+00	1220.00
IUUC-Ocu-074852	Oryctolagus cuniculus	93.81	0.00e+00	1380.00
IUUC-Oga-089048	Otolemur garnettii	87.78	0.00e+00	1207.00
IUUC-Oar-089339	Ovis aries	94.46	0.00e+00	1406.00
IUUC-Pan-092666	Papio anubis	97.43	0.00e+00	1426.00
IUUC-Psi-093116	Pelodiscus sinensis	75.29	0.00e+00	1166.00
IUUC-Pfo-097394	Poecilia formosa	62.39	0.00e+00	935.00
IUUC-Pab-098567	Pongo abelii	99.10	0.00e+00	1471.00
IUUC-Pca-100997	Procavia capensis	79.38	0.00e+00	1110.00
IUUC-Pva-102500	Pteropus vampyrus	92.40	0.00e+00	1338.00
IUUC-Rno-104974	Rattus norvegicus	91.23	0.00e+00	1310.00
IUUC-Sar-113420	Sorex araneus	88.14	0.00e+00	1286.00
IUUC-Ssc-115679	Sus scrofa	94.51	0.00e+00	1244.00
IUUC-Tgu-117069	Taeniopygia guttata	74.87	0.00e+00	1123.00
IUUC-Tru-118488	Takifugu rubripes	56.27	0.00e+00	824.00
IUUC-Tsy-119243	Tarsius syrichta	87.50	0.00e+00	965.00
IUUC-Tni-120584	Tetraodon nigroviridis	60.33	0.00e+00	921.00
IUUC-Tbe-127994	Tupaia belangeri	78.74	0.00e+00	1135.00
IUUC-Ttr-128839	Tursiops truncatus	92.65	0.00e+00	1341.00
IUUC-Vpa-130144	Vicugna pacos	85.47	0.00e+00	1199.00
IUUC-Xtr-132624	Xenopus tropicalis	70.95	0.00e+00	1081.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence