iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022538

Ensembl Protein ID

ENSCPOP00000007076.2

UniProt Accession

H0VB15; H0VB15_CAVPO

Genbank Protein ID

ENSCPOP00000007076

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAKN02012504

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000007861.3	ENSCPOT00000007936.2	ENSCPOP00000007076.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.40e-15	55.7	56	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++ v +lydy+a + ++L+++kGd++ v+   e++++W+++ + ++ k+G +P+n+v+ ++
   Q: 56   QDFIVVALYDYDAIHREDLSFQKGDQMVVL---EESGEWWRARSLATRKEGYIPSNYVACVN 114
           57899*************************...99***********************9876 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

RMGCVKSKFL RDRGKGSKTE SSSNLHTPVY VPDPTSSLKP GPNSHSNPPG LLEGSQDFIV 60
VALYDYDAIH REDLSFQKGD QMVVLEESGE WWRARSLATR KEGYIPSNYV ACVNSLETEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATGGGAT GTGTGAAGTC CAAGTTCCTC CGGGATAGAG GGAAAGGCTC CAAAACCGAG 60
TCTAGCTCCA ACTTGCACAC CCCTGTGTAT GTACCGGATC CCACGTCCTC GCTCAAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	89.55	0.00e+00	936.00
IUUC-Apl-003285	Anas platyrhynchos	76.97	0.00e+00	794.00
IUUC-Aca-004724	Anolis carolinensis	77.80	0.00e+00	790.00
IUUC-Ame-011954	Astyanax mexicanus	75.30	0.00e+00	765.00
IUUC-Bta-013060	Bos taurus	91.49	0.00e+00	956.00
IUUC-Cja-019817	Callithrix jacchus	88.95	0.00e+00	922.00
IUUC-Cfa-020511	Canis familiaris	89.90	0.00e+00	945.00
IUUC-Csa-024143	Chlorocebus sabaeus	90.12	0.00e+00	948.00
IUUC-Dre-028157	Danio rerio	75.25	0.00e+00	782.00
IUUC-Dno-029761	Dasypus novemcinctus	88.10	0.00e+00	929.00
IUUC-Eca-034090	Equus caballus	87.72	0.00e+00	917.00
IUUC-Fca-035937	Felis catus	87.52	0.00e+00	895.00
IUUC-Fal-036624	Ficedula albicollis	76.82	0.00e+00	792.00
IUUC-Gmo-039009	Gadus morhua	72.56	0.00e+00	755.00
IUUC-Gga-040296	Gallus gallus	73.92	0.00e+00	774.00
IUUC-Gac-042362	Gasterosteus aculeatus	73.43	0.00e+00	768.00
IUUC-Ggo-044570	Gorilla gorilla	89.74	0.00e+00	936.00
IUUC-Hsa-046378	Homo sapiens	90.53	0.00e+00	951.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	90.30	0.00e+00	962.00
IUUC-Loc-052904	Lepisosteus oculatus	76.82	0.00e+00	806.00
IUUC-Laf-053654	Loxodonta africana	89.88	0.00e+00	946.00
IUUC-Mcc-055317	Macaca mulatta	90.30	0.00e+00	952.00
IUUC-Mga-060194	Meleagris gallopavo	78.89	0.00e+00	756.00
IUUC-Mmr-061510	Microcebus murinus	88.12	0.00e+00	926.00
IUUC-Mdo-062035	Monodelphis domestica	83.04	0.00e+00	867.00
IUUC-Mmu-064037	Mus musculus	90.10	0.00e+00	954.00
IUUC-Mpu-066874	Mustela putorius furo	89.31	0.00e+00	939.00
IUUC-Mlu-068202	Myotis lucifugus	85.15	0.00e+00	889.00
IUUC-Nle-069222	Nomascus leucogenys	90.10	0.00e+00	946.00
IUUC-Opr-070705	Ochotona princeps	86.96	0.00e+00	919.00
IUUC-Ont-072347	Oreochromis niloticus	81.88	0.00e+00	758.00
IUUC-Ocu-074490	Oryctolagus cuniculus	88.89	0.00e+00	929.00
IUUC-Ola-086521	Oryzias latipes	79.64	0.00e+00	762.00
IUUC-Oga-088153	Otolemur garnettii	88.74	0.00e+00	935.00
IUUC-Oar-090184	Ovis aries	91.14	0.00e+00	953.00
IUUC-Ptr-090505	Pan troglodytes	86.00	0.00e+00	885.00
IUUC-Pan-092260	Papio anubis	90.30	0.00e+00	952.00
IUUC-Pma-094311	Petromyzon marinus	68.30	0.00e+00	734.00
IUUC-Pfo-096566	Poecilia formosa	75.00	0.00e+00	787.00
IUUC-Pva-103021	Pteropus vampyrus	90.30	0.00e+00	951.00
IUUC-Rno-105309	Rattus norvegicus	89.48	0.00e+00	947.00
IUUC-Sha-107099	Sarcophilus harrisii	80.74	0.00e+00	860.00
IUUC-Tgu-116912	Taeniopygia guttata	76.33	0.00e+00	781.00
IUUC-Tru-118449	Takifugu rubripes	79.60	0.00e+00	747.00
IUUC-Tbe-128144	Tupaia belangeri	85.14	0.00e+00	793.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence