iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020563

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03004536

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000018916.3	ENSCAFT00000030021.3	ENSCAFP00000027899.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-13	50.7	129	176

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 129  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 176
           6789*************************...***************9986 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

APPAAPTPAP APAAAPGDTH FRTFRSQAEY RRITRASALL EACGFYWGPL NVHGAHERLR 60
AEPVGTFLVR DSRQRNCFFA LSVKMASGPT SIRVHFQAGR FHLDGSRESF DCLFELLEHY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCCCCCCG CGGCCCCGAC CCCGGCCCCG GCCCCGGCCG CGGCCCCCGG AGACACGCAC 60
TTCCGCACGT TCCGCTCGCA AGCCGAGTAC CGGCGCATCA CCCGCGCCAG CGCGCTCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	91.25	2.00e-78	285.00
IUUC-Apl-003313	Anas platyrhynchos	71.43	3.00e-71	260.00
IUUC-Aca-005109	Anolis carolinensis	68.99	8.00e-63	232.00
IUUC-Ame-011550	Astyanax mexicanus	50.00	3.00e-48	184.00
IUUC-Bta-013411	Bos taurus	98.14	8.00e-91	326.00
IUUC-Cja-019595	Callithrix jacchus	97.52	4.00e-90	323.00
IUUC-Cpo-021374	Cavia porcellus	96.89	7.00e-90	322.00
IUUC-Csa-023333	Chlorocebus sabaeus	96.89	8.00e-90	322.00
IUUC-Dre-028507	Danio rerio	46.79	5.00e-44	170.00
IUUC-Dno-029406	Dasypus novemcinctus	96.27	9.00e-89	319.00
IUUC-Ete-032399	Echinops telfairi	97.52	1.00e-89	322.00
IUUC-Eca-033519	Equus caballus	94.38	1.00e-84	305.00
IUUC-Fal-036726	Ficedula albicollis	71.43	3.00e-72	264.00
IUUC-Gmo-039667	Gadus morhua	50.44	2.00e-26	112.00
IUUC-Gga-040970	Gallus gallus	72.33	5.00e-71	260.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.00	2.00e-35	142.00
IUUC-Ggo-045569	Gorilla gorilla	97.50	8.00e-90	322.00
IUUC-Hsa-046010	Homo sapiens	97.52	4.00e-90	323.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	97.52	8.00e-90	322.00
IUUC-Lch-050219	Latimeria chalumnae	61.64	1.00e-60	225.00
IUUC-Loc-052494	Lepisosteus oculatus	57.86	3.00e-54	204.00
IUUC-Laf-054219	Loxodonta africana	95.59	2.00e-71	260.00
IUUC-Mcc-054830	Macaca mulatta	96.89	8.00e-90	322.00
IUUC-Meu-056565	Macropus eugenii	80.75	1.00e-77	281.00
IUUC-Mga-060153	Meleagris gallopavo	70.81	2.00e-70	258.00
IUUC-Mmr-061365	Microcebus murinus	97.52	4.00e-90	323.00
IUUC-Mdo-062824	Monodelphis domestica	80.75	4.00e-77	280.00
IUUC-Mmu-064120	Mus musculus	95.03	2.00e-88	318.00
IUUC-Mpu-066839	Mustela putorius furo	97.52	3.00e-90	324.00
IUUC-Mlu-067829	Myotis lucifugus	95.03	3.00e-88	317.00
IUUC-Nle-069592	Nomascus leucogenys	93.79	2.00e-86	311.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	8.00e-38	149.00
IUUC-Oan-073586	Ornithorhynchus anatinus	54.21	1.00e-25	108.00
IUUC-Ocu-073996	Oryctolagus cuniculus	96.27	4.00e-89	320.00
IUUC-Oba-075150	Oryza barthii	30.59	3.40e-02	31.20
IUUC-Ola-087158	Oryzias latipes	46.25	2.00e-39	154.00
IUUC-Oga-088076	Otolemur garnettii	95.65	5.00e-89	320.00
IUUC-Ptr-091241	Pan troglodytes	97.52	3.00e-90	323.00
IUUC-Pan-091836	Papio anubis	96.88	2.00e-89	320.00
IUUC-Psi-093628	Pelodiscus sinensis	73.91	1.00e-72	265.00
IUUC-Pfo-097501	Poecilia formosa	45.28	1.00e-36	146.00
IUUC-Pab-098170	Pongo abelii	97.52	4.00e-90	323.00
IUUC-Pop-100072	Populus trichocarpa	32.69	1.50e-02	33.50
IUUC-Pva-102796	Pteropus vampyrus	98.14	1.00e-90	325.00
IUUC-Rno-105319	Rattus norvegicus	95.03	2.00e-88	318.00
IUUC-Sha-107201	Sarcophilus harrisii	79.87	4.00e-73	266.00
IUUC-Ssc-116004	Sus scrofa	97.52	6.00e-90	323.00
IUUC-Tgu-116836	Taeniopygia guttata	72.67	4.00e-72	263.00
IUUC-Tru-118090	Takifugu rubripes	43.75	2.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	44.38	2.00e-32	132.00
IUUC-Vpa-130235	Vicugna pacos	97.52	5.00e-90	323.00
IUUC-Xtr-132610	Xenopus tropicalis	63.35	2.00e-64	238.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence