iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066913

Ensembl Protein ID

ENSMPUP00000002739.1

UniProt Accession

M3XUI9; M3XUI9_MUSPF

Genbank Protein ID

ENSMPUP00000002739

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01033763

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002766.1	ENSMPUT00000002796.1	ENSMPUP00000002739.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	8.30e-06	25.9	40	84
E3 adaptor/Cullin RING/DCX/DWD	1.00e-12	47.8	360	392
UBD/Beta-Prp	3.80e-41	141.2	129	431

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
              +lp+e+ ++i+++ld++el+r+a+v+++w+ +a+++ lw ++
   Q: 40   FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 84
           5679*****************************999999999765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
            tc+++  s  +l+vsG+ D  +++ Dlrt++ 
   Q: 360  FTCVNLrdSPpNLMVSGNMDRRVRIHDLRTDKI 392
           5899*9973359******************975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheae....vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++      ++++++e++    v+ v+++++  + v + eD+++++wdl+t
   Q: 129  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYtapflESEYEEDEPGmqpyVSFVRINSS--LAVAAYEDGFLNIWDLRT 213
           567778999998888..9***********************7777433334444449999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++ 
   Q: 214  GKYPVHRFEHDARIQALALSQDDVTVATASAFDVVMLRPSEEGYWQITAEFEVQKLVDYLEIVPDTeRYPVAVATAGDL-VYLLKAEDS 301
           ***999999**************************************9******************************9.5******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl     ++v++l+++ n+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +  +++vsg++D+ +ri+dlr++
   Q: 302  ARTLHYVYGQPVTCLDVSANQaafgvKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNLRdSPPNLMVSGNMDRRVRIHDLRTD 390
           ****999********************************************************9978899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+  v++v++   +d+++v+g+e++ v +w++++++
   Q: 391  KIALSLSAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRMSQ 431
           **********99999999...*******************9876 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

XQDSASRSRS PPAREVAGGG EQLVDQLIRD LNEMDDVPFF DIQLPYELAI NIFQYLDRKE 60
LGRCAQVSKT WKVIAEDEVL WYRLCQQEGH LPESSISDYS CWKLIFQECR AKEHMLRTNW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NGGCAGGACT CAGCAAGCCG TTCCCGCTCC CCTCCGGCTC GCGAGGTTGC CGGGGGCGGG 60
GAGCAGCTGG TGGACCAGCT CATCCGCGAC CTGGTGAGTG GCCGTCACCT CCTGCCGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	97.49	0.00e+00	1048.00
IUUC-Apl-003239	Anas platyrhynchos	64.74	0.00e+00	719.00
IUUC-Aca-004756	Anolis carolinensis	61.94	6.00e-140	490.00
IUUC-Ame-011198	Astyanax mexicanus	55.14	1.00e-57	216.00
IUUC-Bta-012430	Bos taurus	58.41	2.00e-155	542.00
IUUC-Cja-019131	Callithrix jacchus	83.01	0.00e+00	871.00
IUUC-Cfa-021022	Canis familiaris	95.80	0.00e+00	996.00
IUUC-Cpo-021898	Cavia porcellus	89.22	0.00e+00	947.00
IUUC-Csa-023452	Chlorocebus sabaeus	87.84	0.00e+00	924.00
IUUC-Cho-024759	Choloepus hoffmanni	79.15	0.00e+00	832.00
IUUC-Dre-028123	Danio rerio	49.14	4.00e-150	525.00
IUUC-Dno-029045	Dasypus novemcinctus	94.04	0.00e+00	890.00
IUUC-Dor-030433	Dipodomys ordii	83.76	0.00e+00	818.00
IUUC-Ete-032465	Echinops telfairi	88.56	0.00e+00	796.00
IUUC-Eca-034134	Equus caballus	94.67	0.00e+00	965.00
IUUC-Eeu-035047	Erinaceus europaeus	83.20	0.00e+00	833.00
IUUC-Fca-036574	Felis catus	94.67	0.00e+00	962.00
IUUC-Fal-037665	Ficedula albicollis	62.58	0.00e+00	637.00
IUUC-Gmo-039137	Gadus morhua	46.48	2.00e-67	249.00
IUUC-Gga-040711	Gallus gallus	64.90	0.00e+00	694.00
IUUC-Gac-041675	Gasterosteus aculeatus	55.08	6.00e-56	209.00
IUUC-Ggo-045331	Gorilla gorilla	87.09	0.00e+00	880.00
IUUC-Hsa-046240	Homo sapiens	87.84	0.00e+00	937.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	93.65	0.00e+00	935.00
IUUC-Loc-052631	Lepisosteus oculatus	56.37	4.00e-174	604.00
IUUC-Laf-054127	Loxodonta africana	80.58	5.00e-61	226.00
IUUC-Mcc-055083	Macaca mulatta	88.42	0.00e+00	939.00
IUUC-Mga-060113	Meleagris gallopavo	65.17	0.00e+00	681.00
IUUC-Mmr-061780	Microcebus murinus	92.28	0.00e+00	967.00
IUUC-Mdo-063066	Monodelphis domestica	68.91	0.00e+00	748.00
IUUC-Mmu-063524	Mus musculus	86.77	0.00e+00	887.00
IUUC-Mlu-067924	Myotis lucifugus	92.29	0.00e+00	972.00
IUUC-Nle-069558	Nomascus leucogenys	87.73	0.00e+00	898.00
IUUC-Opr-070506	Ochotona princeps	89.98	0.00e+00	957.00
IUUC-Ont-071514	Oreochromis niloticus	50.40	1.00e-149	523.00
IUUC-Ocu-074477	Oryctolagus cuniculus	90.52	0.00e+00	923.00
IUUC-Ola-087416	Oryzias latipes	50.30	2.00e-147	515.00
IUUC-Oga-088643	Otolemur garnettii	93.63	0.00e+00	985.00
IUUC-Oar-090172	Ovis aries	93.85	0.00e+00	961.00
IUUC-Ptr-090870	Pan troglodytes	87.84	0.00e+00	931.00
IUUC-Pan-092017	Papio anubis	87.64	0.00e+00	929.00
IUUC-Psi-093794	Pelodiscus sinensis	66.60	0.00e+00	689.00
IUUC-Pfo-096192	Poecilia formosa	52.37	5.00e-153	534.00
IUUC-Pab-097882	Pongo abelii	87.16	0.00e+00	914.00
IUUC-Pca-100902	Procavia capensis	90.67	3.00e-146	511.00
IUUC-Pva-103139	Pteropus vampyrus	93.43	0.00e+00	982.00
IUUC-Rno-105798	Rattus norvegicus	85.88	0.00e+00	909.00
IUUC-Sha-106576	Sarcophilus harrisii	68.39	0.00e+00	709.00
IUUC-Ssc-115923	Sus scrofa	84.39	0.00e+00	907.00
IUUC-Tgu-116667	Taeniopygia guttata	57.95	5.00e-122	430.00
IUUC-Tru-118323	Takifugu rubripes	47.98	4.00e-143	501.00
IUUC-Tsy-118818	Tarsius syrichta	78.00	2.00e-107	382.00
IUUC-Tni-120438	Tetraodon nigroviridis	47.86	9.00e-137	480.00
IUUC-Tbe-127784	Tupaia belangeri	95.15	3.00e-114	405.00
IUUC-Ttr-128288	Tursiops truncatus	84.83	0.00e+00	871.00
IUUC-Vpa-130307	Vicugna pacos	90.37	0.00e+00	848.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence