iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046865

UUCD1 version

UUC-HoS-00173

Ensembl Protein ID

ENSP00000322937.4

UniProt Accession

Q6UWE0; Q5VVV0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7; LRSM1_HUMAN

Genbank Protein ID

AAQ89189.1; BAB71119.1; BAB71144.1; BAC03703.1; CAH72930.1; CAH72931.1; AAH09239.1

Protein Name

E3 ubiquitin-protein ligase LRSAM1; Leucine-rich repeat and sterile alpha motif-containing protein 1; RING-type E3 ubiquitin transferase LRSAM1; Tsg101-associated ligase

Genbank Nucleotide ID

AY358830; AK056203; AK056305; AK091589; AL445222; AL445222; BC009239

Gene Name

LRSAM1; TAL; UNQ6496/PRO21356

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000148356.13	ENST00000373324.8	ENSP00000362421.4
ENSG00000148356.13	ENST00000323301.8	ENSP00000322937.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19703557; 23519028

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098).

Protein Sequence
(Fasta)

MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL 60
IVHTNHLTSL LPKSCSLLSL ATIKVLDLHD NQLTALPDDL GQLTALQVLN VERNQLMQLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGACGCCC TTGTCGCCAT GTTTGTTGTG GGCAGGCGCC TGAGGCTGAC GGCTGGCAAG 60
CAGGGCACCG CGGTGCGCTG AAGCTAGAGA TTCCGAAAGG GGGTTCGGGT AGTTCGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0144--Charcot-Marie-Tooth disease
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR001660--SAM
IPR013761--SAM/pointed
IPR001841--Znf_RING

PROSITE

PS51450--LRR
PS50105--SAM_DOMAIN
PS50089--ZF_RING_2

Pfam

PF13855--LRR_8
PF07647--SAM_2

SMART

SM00369--LRR_TYP
SM00454--SAM

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0045806--P:negative regulation of endocytosis
GO:2000786--P:positive regulation of autophagosome assembly
GO:1904417--P:positive regulation of xenophagy
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007165--P:signal transduction
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0046755--P:viral budding

KEGG

hsa:90678

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001663	Ailuropoda melanoleuca	87.93	0.00e+00	1086.00
IUUC-Apl-004029	Anas platyrhynchos	72.79	0.00e+00	629.00
IUUC-Aca-004487	Anolis carolinensis	63.60	0.00e+00	724.00
IUUC-Aly-005571	Arabidopsis lyrata	31.39	2.00e-13	72.00
IUUC-Ath-006853	Arabidopsis thaliana	31.85	8.00e-17	81.60
IUUC-Ame-011792	Astyanax mexicanus	56.19	0.00e+00	723.00
IUUC-Bta-012937	Bos taurus	91.17	0.00e+00	1142.00
IUUC-Bdi-014104	Brachypodium distachyon	33.33	3.00e-09	56.20
IUUC-Bol-016339	Brassica oleracea	30.14	8.00e-15	74.70
IUUC-Bra-016795	Brassica rapa	30.14	1.00e-14	73.90
IUUC-Cja-019359	Callithrix jacchus	94.45	0.00e+00	1141.00
IUUC-Cfa-020908	Canis familiaris	90.52	0.00e+00	1113.00
IUUC-Cpo-021744	Cavia porcellus	85.28	0.00e+00	1024.00
IUUC-Cre-022825	Chlamydomonas reinhardtii	45.76	8.00e-08	51.60
IUUC-Csa-023784	Chlorocebus sabaeus	98.06	0.00e+00	1229.00
IUUC-Cin-025241	Ciona intestinalis	36.99	8.00e-101	361.00
IUUC-Dre-027424	Danio rerio	56.67	0.00e+00	695.00
IUUC-Dno-028857	Dasypus novemcinctus	90.37	0.00e+00	1100.00
IUUC-Dor-030397	Dipodomys ordii	80.83	1.00e-104	374.00
IUUC-Ete-032958	Echinops telfairi	72.08	6.00e-155	541.00
IUUC-Eca-033505	Equus caballus	91.29	0.00e+00	1144.00
IUUC-Eeu-035089	Erinaceus europaeus	79.57	0.00e+00	855.00
IUUC-Fca-036318	Felis catus	90.38	0.00e+00	1112.00
IUUC-Fal-037299	Ficedula albicollis	70.94	0.00e+00	811.00
IUUC-Gmo-038494	Gadus morhua	58.27	0.00e+00	674.00
IUUC-Gga-041180	Gallus gallus	71.70	0.00e+00	882.00
IUUC-Gac-041975	Gasterosteus aculeatus	54.57	0.00e+00	635.00
IUUC-Gma-043846	Glycine max	33.33	1.00e-09	57.40
IUUC-Ggo-045293	Gorilla gorilla	94.19	0.00e+00	1157.00
IUUC-Hvu-047769	Hordeum vulgare	27.98	3.00e-13	69.30
IUUC-Itr-048290	Ictidomys tridecemlineatus	89.68	0.00e+00	1097.00
IUUC-Lch-049955	Latimeria chalumnae	53.76	3.00e-175	608.00
IUUC-Loc-052396	Lepisosteus oculatus	50.98	2.00e-142	499.00
IUUC-Laf-054274	Loxodonta africana	92.03	0.00e+00	1091.00
IUUC-Mcc-055328	Macaca mulatta	98.20	0.00e+00	1231.00
IUUC-Meu-056407	Macropus eugenii	75.70	1.00e-82	301.00
IUUC-Mtr-057683	Medicago truncatula	29.35	3.00e-15	76.30
IUUC-Mga-059898	Meleagris gallopavo	72.12	0.00e+00	892.00
IUUC-Mmr-061558	Microcebus murinus	91.07	0.00e+00	1157.00
IUUC-Mdo-062877	Monodelphis domestica	79.59	0.00e+00	994.00
IUUC-Mmu-063525	Mus musculus	87.48	0.00e+00	1102.00
IUUC-Mac-064501	Musa acuminata	40.00	7.00e-14	71.60
IUUC-Mpu-066491	Mustela putorius furo	87.76	0.00e+00	1037.00
IUUC-Mlu-068182	Myotis lucifugus	85.58	0.00e+00	984.00
IUUC-Nle-069349	Nomascus leucogenys	96.96	0.00e+00	1195.00
IUUC-Opr-070326	Ochotona princeps	78.20	0.00e+00	862.00
IUUC-Ont-071685	Oreochromis niloticus	55.37	0.00e+00	701.00
IUUC-Oan-072957	Ornithorhynchus anatinus	82.17	0.00e+00	981.00
IUUC-Obr-076454	Oryza brachyantha	33.76	5.00e-16	79.00
IUUC-Ogl-077480	Oryza glaberrima	32.48	2.00e-14	73.60
IUUC-Oin-079319	Oryza indica	31.21	9.00e-14	72.00
IUUC-Olo-081076	Oryza longistaminata	26.92	5.00e-06	47.40
IUUC-Oni-083060	Oryza nivara	33.33	1.10e-02	36.20
IUUC-Oga-088129	Otolemur garnettii	92.39	0.00e+00	1133.00
IUUC-Oar-089353	Ovis aries	85.01	0.00e+00	1006.00
IUUC-Ptr-091511	Pan troglodytes	98.76	0.00e+00	1233.00
IUUC-Pan-092251	Papio anubis	97.93	0.00e+00	1227.00
IUUC-Psi-093778	Pelodiscus sinensis	63.18	0.00e+00	734.00
IUUC-Pma-094158	Petromyzon marinus	45.44	4.00e-126	445.00
IUUC-Ppa-095427	Physcomitrella patens	32.48	1.00e-14	73.90
IUUC-Pfo-096094	Poecilia formosa	54.90	0.00e+00	654.00
IUUC-Pab-098187	Pongo abelii	93.08	0.00e+00	1136.00
IUUC-Pop-099197	Populus trichocarpa	30.86	1.00e-14	73.90
IUUC-Pca-100526	Procavia capensis	87.15	2.00e-142	499.00
IUUC-Ppe-101851	Prunus persica	38.46	4.00e-15	75.50
IUUC-Pva-102557	Pteropus vampyrus	87.43	0.00e+00	1041.00
IUUC-Pgr-103622	Puccinia graminis	34.82	3.00e-13	72.00
IUUC-Pyt-104751	Pyrenophora triticirepentis	38.64	1.00e-14	75.50
IUUC-Rno-105540	Rattus norvegicus	85.99	0.00e+00	1095.00
IUUC-Sha-107485	Sarcophilus harrisii	80.61	0.00e+00	979.00
IUUC-Spo-108106	Schizosaccharomyces pombe	33.04	7.00e-14	73.20
IUUC-Sit-110214	Setaria italica	33.33	3.00e-10	59.70
IUUC-Stu-112067	Solanum tuberosum	28.87	2.00e-16	79.70
IUUC-Sar-113098	Sorex araneus	74.10	0.00e+00	816.00
IUUC-Sbi-114187	Sorghum bicolor	35.42	4.00e-10	59.30
IUUC-Ssc-116105	Sus scrofa	86.84	0.00e+00	1030.00
IUUC-Tgu-116857	Taeniopygia guttata	72.42	0.00e+00	651.00
IUUC-Tru-117930	Takifugu rubripes	52.46	0.00e+00	658.00
IUUC-Tsy-119382	Tarsius syrichta	79.75	5.00e-94	338.00
IUUC-Tni-120714	Tetraodon nigroviridis	54.47	0.00e+00	637.00
IUUC-Tca-121678	Theobroma cacao	30.57	8.00e-15	74.70
IUUC-Tae-125723	Triticum aestivum	26.45	2.00e-13	70.10
IUUC-Tbe-127528	Tupaia belangeri	75.00	2.00e-78	287.00
IUUC-Ttr-128282	Tursiops truncatus	91.11	0.00e+00	1113.00
IUUC-Vda-129866	Verticillium dahliae	36.62	2.00e-07	52.00
IUUC-Vpa-130740	Vicugna pacos	76.86	0.00e+00	749.00
IUUC-Vvi-131120	Vitis vinifera	34.31	2.00e-12	66.60
IUUC-Xtr-132037	Xenopus tropicalis	60.17	0.00e+00	694.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence