iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062122

Ensembl Protein ID

ENSMODP00000008410.1

UniProt Accession

F6PH04; F6PH04_MONDO

Protein Name

Presenilin

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006792.2	ENSMODT00000008578.2	ENSMODP00000008410.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.60e-08	34.6	275	313

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ +  
   Q: 275  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVS 313
           89***************************9999987765 PP

Organism

Monodelphis domestica

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MTELSAPLPY FQNAQMTEDS HMSNTVRNQN DGRERQRHEH SERRRHGNNS EAETNGQPQG 60
GTRQVVENDD EEDEELTLKY GAKHVIMLFV PVTLCMVVVV ATIKSVSFYT RKDGQLIYTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTGCAAGA GATTTTGTGT TTTTGTGGAA AAGAGAAGTG TGTCTGTAAG ACTGCTCCAA 60
TGACTGAGCT GTCTGCACCC TTACCCTACT TCCAGAATGC TCAGATGACA GAAGATAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0031410--C:cytoplasmic vesicle
GO:0043198--C:dendritic shaft
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005262--F:calcium channel activity
GO:0004175--F:endopeptidase activity
GO:0000186--P:activation of MAPKK activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0000045--P:autophagosome assembly
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0001568--P:blood vessel development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0001708--P:cell fate specification
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0050673--P:epithelial cell proliferation
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0051402--P:neuron apoptotic process
GO:0048666--P:neuron development
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

KEGG

mdo:100019628

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	34.11	7.00e-22	99.40
IUUC-Aml-001648	Ailuropoda melanoleuca	89.34	1.00e-157	549.00
IUUC-Atr-003039	Amborella trichopoda	31.90	6.00e-38	151.00
IUUC-Apl-003727	Anas platyrhynchos	82.95	0.00e+00	629.00
IUUC-Aca-004582	Anolis carolinensis	79.96	0.00e+00	631.00
IUUC-Aly-005455	Arabidopsis lyrata	58.82	2.00e-17	84.00
IUUC-Ath-006730	Arabidopsis thaliana	32.56	9.00e-18	84.70
IUUC-Ame-011500	Astyanax mexicanus	74.22	9.00e-151	526.00
IUUC-Bta-013026	Bos taurus	84.20	0.00e+00	671.00
IUUC-Bdi-014196	Brachypodium distachyon	32.71	9.00e-28	118.00
IUUC-Bol-015841	Brassica oleracea	35.35	7.00e-31	128.00
IUUC-Bra-017580	Brassica rapa	56.70	1.00e-17	84.30
IUUC-Cel-018553	Caenorhabditis elegans	50.11	2.00e-96	346.00
IUUC-Cja-019994	Callithrix jacchus	89.39	0.00e+00	634.00
IUUC-Cfa-020074	Canis familiaris	87.69	0.00e+00	690.00
IUUC-Cpo-022237	Cavia porcellus	87.58	0.00e+00	652.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.70	7.00e-29	122.00
IUUC-Csa-023537	Chlorocebus sabaeus	87.90	0.00e+00	706.00
IUUC-Cho-024735	Choloepus hoffmanni	78.13	4.00e-180	624.00
IUUC-Cin-025780	Ciona intestinalis	62.03	3.00e-126	444.00
IUUC-Csv-025967	Ciona savignyi	62.69	6.00e-120	424.00
IUUC-Dre-028689	Danio rerio	72.73	3.00e-146	511.00
IUUC-Dno-029758	Dasypus novemcinctus	88.11	0.00e+00	683.00
IUUC-Dor-030609	Dipodomys ordii	67.30	1.00e-155	543.00
IUUC-Dme-031929	Drosophila melanogaster	56.28	1.00e-110	393.00
IUUC-Ete-032487	Echinops telfairi	78.67	2.00e-78	286.00
IUUC-Eeu-035134	Erinaceus europaeus	87.34	1.00e-134	472.00
IUUC-Fca-036243	Felis catus	88.32	0.00e+00	686.00
IUUC-Fal-036600	Ficedula albicollis	81.86	0.00e+00	634.00
IUUC-Gga-040993	Gallus gallus	83.76	0.00e+00	639.00
IUUC-Gac-042342	Gasterosteus aculeatus	65.74	3.00e-130	458.00
IUUC-Gma-043822	Glycine max	38.29	1.00e-24	107.00
IUUC-Ggo-044859	Gorilla gorilla	85.19	5.00e-149	520.00
IUUC-Hsa-046822	Homo sapiens	87.69	0.00e+00	704.00
IUUC-Hvu-047141	Hordeum vulgare	33.66	9.00e-22	98.20
IUUC-Itr-048420	Ictidomys tridecemlineatus	89.16	2.00e-147	514.00
IUUC-Lch-049946	Latimeria chalumnae	68.50	9.00e-148	516.00
IUUC-Lpe-051132	Leersia perrieri	32.58	2.00e-28	119.00
IUUC-Loc-052469	Lepisosteus oculatus	67.26	1.00e-142	499.00
IUUC-Laf-053979	Loxodonta africana	86.55	1.00e-172	599.00
IUUC-Mcc-055682	Macaca mulatta	87.69	0.00e+00	704.00
IUUC-Meu-056004	Macropus eugenii	82.58	8.00e-171	593.00
IUUC-Mga-059466	Meleagris gallopavo	82.91	0.00e+00	635.00
IUUC-Mmr-061538	Microcebus murinus	71.34	4.00e-148	517.00
IUUC-Mmu-063176	Mus musculus	85.35	0.00e+00	669.00
IUUC-Mpu-065927	Mustela putorius furo	87.26	0.00e+00	676.00
IUUC-Mlu-067079	Myotis lucifugus	87.47	0.00e+00	708.00
IUUC-Nle-070180	Nomascus leucogenys	87.69	0.00e+00	704.00
IUUC-Opr-070847	Ochotona princeps	81.29	1.00e-177	615.00
IUUC-Ont-071846	Oreochromis niloticus	76.05	1.00e-147	516.00
IUUC-Oan-072783	Ornithorhynchus anatinus	84.10	9.00e-138	482.00
IUUC-Ocu-074527	Oryctolagus cuniculus	86.86	0.00e+00	692.00
IUUC-Oba-075256	Oryza barthii	33.03	7.00e-27	114.00
IUUC-Obr-076302	Oryza brachyantha	42.76	2.00e-16	80.90
IUUC-Ogl-077097	Oryza glaberrima	32.12	1.00e-27	117.00
IUUC-Ogu-078570	Oryza glumaepatula	32.56	1.00e-27	117.00
IUUC-Olo-080484	Oryza longistaminata	35.36	2.00e-23	102.00
IUUC-Ome-081814	Oryza meridionalis	32.12	5.00e-28	118.00
IUUC-Oru-084618	Oryza rufipogon	32.56	2.00e-27	117.00
IUUC-Osa-085602	Oryza sativa	32.56	2.00e-27	117.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.19	6.00e-45	174.00
IUUC-Oar-090348	Ovis aries	85.99	0.00e+00	708.00
IUUC-Ptr-091060	Pan troglodytes	87.69	0.00e+00	704.00
IUUC-Pan-091855	Papio anubis	81.74	3.00e-179	621.00
IUUC-Psi-093505	Pelodiscus sinensis	81.86	0.00e+00	635.00
IUUC-Pfo-097396	Poecilia formosa	73.43	1.00e-153	536.00
IUUC-Pab-098591	Pongo abelii	87.05	0.00e+00	692.00
IUUC-Pop-099661	Populus trichocarpa	32.17	1.00e-32	134.00
IUUC-Pca-101029	Procavia capensis	85.35	0.00e+00	645.00
IUUC-Ppe-101495	Prunus persica	31.39	7.00e-37	148.00
IUUC-Pva-102244	Pteropus vampyrus	81.10	0.00e+00	628.00
IUUC-Rno-105861	Rattus norvegicus	85.84	0.00e+00	659.00
IUUC-Sha-107045	Sarcophilus harrisii	96.39	0.00e+00	765.00
IUUC-Smo-109325	Selaginella moellendorffii	34.64	2.00e-36	146.00
IUUC-Stu-112433	Solanum tuberosum	35.08	1.00e-33	137.00
IUUC-Sar-113169	Sorex araneus	84.79	7.00e-136	477.00
IUUC-Sbi-114305	Sorghum bicolor	33.54	2.00e-24	107.00
IUUC-Ssc-115766	Sus scrofa	87.26	0.00e+00	683.00
IUUC-Tgu-116469	Taeniopygia guttata	86.47	8.00e-140	489.00
IUUC-Tru-117732	Takifugu rubripes	75.31	1.00e-145	509.00
IUUC-Tsy-119624	Tarsius syrichta	80.25	0.00e+00	634.00
IUUC-Tni-119852	Tetraodon nigroviridis	69.91	2.00e-138	485.00
IUUC-Tca-121865	Theobroma cacao	32.91	6.00e-37	148.00
IUUC-Tae-125925	Triticum aestivum	36.25	6.00e-26	111.00
IUUC-Tur-126237	Triticum urartu	35.10	7.00e-22	98.20
IUUC-Tbe-128148	Tupaia belangeri	77.63	4.00e-153	534.00
IUUC-Ttr-128793	Tursiops truncatus	85.77	0.00e+00	664.00
IUUC-Vpa-130625	Vicugna pacos	70.43	3.00e-148	518.00
IUUC-Vvi-131312	Vitis vinifera	33.67	7.00e-35	141.00
IUUC-Xtr-131790	Xenopus tropicalis	78.60	2.00e-161	562.00
IUUC-Xma-133377	Xiphophorus maculatus	74.82	3.00e-153	535.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence