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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045805
UUCD1 version UUC-HoS-00035
Ensembl Protein ID ENSP00000305133.5
UniProt Accession O75159; Q53SD4; Q8IYZ4; SOCS5_HUMAN
Genbank Protein ID AAD40484.1; BAA31646.2; CAB66830.1; BAF82883.1; AAY24289.1; EAX00236.1; EAX00237.1; AAH32862.1
Protein Name Suppressor of cytokine signaling 5; Cytokine-inducible SH2 protein 6; Cytokine-inducible SH2-containing protein 5
Genbank Nucleotide ID AF073958; AB014571; AL136896; AK290194; AC020604; CH471053; CH471053; BC032862
Gene Name SOCS5; CIS6; CISH5; CISH6; KIAA0671
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000171150.7 ENST00000306503.5 ENSP00000305133.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
miRecordsRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
InWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 15695332
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.20e-15 58.8 473 520
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 520
           6778999**********************...****************985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Protein Sequence
(Fasta)
MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS TPQQQSSPLR 60
ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045805|E3,SOCS|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCAGCCGCG CAGAGCGCGC ACCCAAGCGG CCGGACCTCC CCGACTCCCG GGCCGCCCCC 60
GTCTCGCGCC CTGCCTCCCT CCTTCGGCCT TCACCTACCC GCCTCCGGAT TGGCCGCTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045805|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004860--F:protein kinase inhibitor activity
GO:0030971--F:receptor tyrosine kinase binding
GO:0016049--P:cell growth
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0009968--P:negative regulation of signal transduction
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
GO:0097699--P:vascular endothelial cell response to fluid shear stress
KEGG hsa:9655
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000371 Aegilops tauschii 36.73 1.50e-02 32.70
IUUC-Apl-003815 Anas platyrhynchos 91.60 0.00e+00 1012.00
IUUC-Aca-004504 Anolis carolinensis 85.07 0.00e+00 878.00
IUUC-Ame-010677 Astyanax mexicanus 63.46 0.00e+00 645.00
IUUC-Bta-012338 Bos taurus 97.95 0.00e+00 1052.00
IUUC-Cja-019828 Callithrix jacchus 98.13 0.00e+00 1029.00
IUUC-Cfa-020369 Canis familiaris 97.57 0.00e+00 1052.00
IUUC-Cpo-021397 Cavia porcellus 95.71 0.00e+00 1057.00
IUUC-Csa-023856 Chlorocebus sabaeus 99.63 0.00e+00 1063.00
IUUC-Dre-028262 Danio rerio 63.56 1.00e-173 603.00
IUUC-Dno-029019 Dasypus novemcinctus 97.95 0.00e+00 1077.00
IUUC-Dme-031965 Drosophila melanogaster 68.02 1.00e-69 258.00
IUUC-Eca-033867 Equus caballus 96.08 0.00e+00 1057.00
IUUC-Fca-035806 Felis catus 97.39 0.00e+00 1046.00
IUUC-Fal-037117 Ficedula albicollis 91.60 0.00e+00 1003.00
IUUC-Fso-038185 Fusarium solani 34.38 5.00e-02 31.60
IUUC-Gmo-039066 Gadus morhua 84.43 1.00e-108 386.00
IUUC-Gga-040876 Gallus gallus 91.04 0.00e+00 987.00
IUUC-Gac-042149 Gasterosteus aculeatus 67.41 0.00e+00 649.00
IUUC-Ggo-045169 Gorilla gorilla 98.88 0.00e+00 1058.00
IUUC-Hvu-047122 Hordeum vulgare 39.02 1.30e-02 33.50
IUUC-Itr-049048 Ictidomys tridecemlineatus 97.20 0.00e+00 1066.00
IUUC-Lch-049686 Latimeria chalumnae 79.41 0.00e+00 845.00
IUUC-Lpe-051639 Leersia perrieri 32.31 3.90e-02 33.50
IUUC-Loc-051745 Lepisosteus oculatus 72.61 0.00e+00 718.00
IUUC-Lma-053042 Leptosphaeria maculans 26.67 4.00e-01 32.70
IUUC-Laf-054124 Loxodonta africana 94.97 0.00e+00 1036.00
IUUC-Mcc-055175 Macaca mulatta 99.63 0.00e+00 1063.00
IUUC-Meu-056557 Macropus eugenii 92.39 0.00e+00 1025.00
IUUC-Mga-059214 Meleagris gallopavo 90.86 0.00e+00 1003.00
IUUC-Mmr-060613 Microcebus murinus 81.90 0.00e+00 815.00
IUUC-Mdo-062788 Monodelphis domestica 91.84 0.00e+00 983.00
IUUC-Mmu-064333 Mus musculus 94.40 0.00e+00 1017.00
IUUC-Mpu-066048 Mustela putorius furo 97.95 0.00e+00 1049.00
IUUC-Mlu-067430 Myotis lucifugus 97.39 0.00e+00 1019.00
IUUC-Nle-069086 Nomascus leucogenys 99.63 0.00e+00 1088.00
IUUC-Opr-070312 Ochotona princeps 92.72 0.00e+00 996.00
IUUC-Ont-072299 Oreochromis niloticus 64.36 0.00e+00 642.00
IUUC-Ocu-074123 Oryctolagus cuniculus 90.49 0.00e+00 972.00
IUUC-Ola-086934 Oryzias latipes 67.10 0.00e+00 662.00
IUUC-Oga-088535 Otolemur garnettii 97.57 0.00e+00 1072.00
IUUC-Oar-089875 Ovis aries 97.39 0.00e+00 1047.00
IUUC-Ptr-090541 Pan troglodytes 100.00 0.00e+00 1065.00
IUUC-Pan-092416 Papio anubis 99.63 0.00e+00 1063.00
IUUC-Psi-092960 Pelodiscus sinensis 89.74 0.00e+00 994.00
IUUC-Pma-094222 Petromyzon marinus 51.44 6.00e-137 481.00
IUUC-Pfo-096930 Poecilia formosa 64.83 0.00e+00 657.00
IUUC-Pab-098659 Pongo abelii 99.63 0.00e+00 1064.00
IUUC-Pca-100222 Procavia capensis 92.74 0.00e+00 1024.00
IUUC-Pva-102387 Pteropus vampyrus 97.39 0.00e+00 1041.00
IUUC-Rno-105698 Rattus norvegicus 95.15 0.00e+00 1028.00
IUUC-Sha-107234 Sarcophilus harrisii 91.09 0.00e+00 988.00
IUUC-Sar-113698 Sorex araneus 88.81 0.00e+00 910.00
IUUC-Ssc-115985 Sus scrofa 97.01 0.00e+00 1063.00
IUUC-Tgu-116676 Taeniopygia guttata 91.98 0.00e+00 1009.00
IUUC-Tru-118441 Takifugu rubripes 58.38 2.00e-150 526.00
IUUC-Tsy-119163 Tarsius syrichta 89.93 0.00e+00 989.00
IUUC-Tni-120436 Tetraodon nigroviridis 66.54 0.00e+00 647.00
IUUC-Tca-121188 Theobroma cacao 34.69 1.50e-01 30.80
IUUC-Tae-124846 Triticum aestivum 36.73 3.10e-02 31.60
IUUC-Tbe-127353 Tupaia belangeri 97.20 0.00e+00 1044.00
IUUC-Ttr-128907 Tursiops truncatus 97.76 0.00e+00 1027.00
IUUC-Vpa-130140 Vicugna pacos 97.39 0.00e+00 1049.00
IUUC-Xtr-132817 Xenopus tropicalis 80.63 0.00e+00 880.00
Created Date 25-Jun-2017

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