iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000003504.2	ENSXETT00000061454.1	ENSXETP00000063075.1
ENSXETG00000003504.2	ENSXETT00000007574.2	ENSXETP00000007574.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-75	255.4	503	829

Active Site

Position(s)	Description	Evidence
799	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + l  +e++G+l+g al+ +++l
   Q: 503  WWECKFIAEGIIDQGGGFRDSLADISEELCPSSadipvpLPFFVRTSNQGNGTGEAQDMYVPNPscKDLAKYEWIGQLMGAALRGKEFL 591
           355*****************************99999999*********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeY 173
            l l+  ++k+l g+++s+ +d+++vd+ l+k l+ ++ +     +e++++++fs   + +++l+++k +eL+pgG+ni+V ++++ e+
   Q: 592  VLALPGLVWKQLTGEEVSWsKDFPAVDSLLVKLLEMMELM-----DEETFEFKFSgelTYTTVLSDQKMVELVPGGSNISVLYKDRVEF 675
           ***********************************99955.....555677777755666777************************** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++ v ++rl+e  keq+ a+++G+ +v+p+ +l+l+t++ele  +cG++ei+ve+lkk t++ g++++++  +q+Fwe+l++f++e+r+
   Q: 676  IRMVQKARLEE-SKEQIGALQAGLLKVVPQAVLDLLTWQELEKRVCGDPEITVEALKKLTRF-GDIEQTDTRVQYFWEALNNFTNEDRS 762
           **********9.9*************************************************.66************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+    +    ++++++    ++dd+lP+s+TC + L LP+Y s +i++ekL+yA  ++ +++
   Q: 763  RFLRFVTGRSRLPA----P----IYIYPDrswLGTDDSLPESSTCSSSLYLPNYASAKICEEKLRYAAYNCVAID 829
           *************5....3....345555578899**********************************998776 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MQAPDNPHRL LGQIRCVLEC IDCFRHVQPL PEALCYVPGE VQYKICKDTS SSSSSRSLLT 60
VWEAPGYAKQ NLKKLSRATV EVRKGSCVTA TGEEYCNANG LWVKLSEAQM EEFKGSCDMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGGCTC CAGATAATCC ACATCGACTA CTGGGCCAAA TCCGCTGTGT TTTGGAGTGT 60
ATCGACTGCT TCCGACATGT GCAGCCCCTC CCCGAGGCCT TATGTTATGT TCCTGGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	64.04	0.00e+00	1115.00
IUUC-Apl-003715	Anas platyrhynchos	72.06	0.00e+00	1085.00
IUUC-Aca-004377	Anolis carolinensis	68.98	0.00e+00	1169.00
IUUC-Ame-011918	Astyanax mexicanus	59.79	0.00e+00	1007.00
IUUC-Bta-012736	Bos taurus	64.62	0.00e+00	1127.00
IUUC-Cja-019926	Callithrix jacchus	64.27	0.00e+00	1120.00
IUUC-Cfa-020753	Canis familiaris	74.35	0.00e+00	905.00
IUUC-Cpo-021415	Cavia porcellus	64.27	0.00e+00	1122.00
IUUC-Csa-023096	Chlorocebus sabaeus	64.30	0.00e+00	1121.00
IUUC-Dre-028746	Danio rerio	63.77	0.00e+00	1083.00
IUUC-Dno-029293	Dasypus novemcinctus	79.47	0.00e+00	901.00
IUUC-Dor-031113	Dipodomys ordii	73.56	0.00e+00	909.00
IUUC-Ete-032601	Echinops telfairi	61.73	0.00e+00	979.00
IUUC-Eca-034198	Equus caballus	63.23	0.00e+00	1114.00
IUUC-Eeu-034708	Erinaceus europaeus	79.02	0.00e+00	756.00
IUUC-Fca-035478	Felis catus	65.19	0.00e+00	1125.00
IUUC-Fal-037366	Ficedula albicollis	68.08	0.00e+00	1140.00
IUUC-Gmo-039020	Gadus morhua	66.56	0.00e+00	883.00
IUUC-Gga-040332	Gallus gallus	71.22	0.00e+00	1206.00
IUUC-Gac-042336	Gasterosteus aculeatus	63.95	0.00e+00	1116.00
IUUC-Ggo-045382	Gorilla gorilla	64.30	0.00e+00	1121.00
IUUC-Hsa-046562	Homo sapiens	64.30	0.00e+00	1121.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	64.39	0.00e+00	1122.00
IUUC-Lch-049606	Latimeria chalumnae	61.09	0.00e+00	775.00
IUUC-Loc-052448	Lepisosteus oculatus	56.88	0.00e+00	947.00
IUUC-Laf-054507	Loxodonta africana	64.58	0.00e+00	1138.00
IUUC-Mcc-055690	Macaca mulatta	64.30	0.00e+00	1121.00
IUUC-Meu-055970	Macropus eugenii	64.74	0.00e+00	1090.00
IUUC-Mga-059654	Meleagris gallopavo	72.64	0.00e+00	1073.00
IUUC-Mmr-061069	Microcebus murinus	64.15	0.00e+00	1118.00
IUUC-Mdo-062547	Monodelphis domestica	80.61	0.00e+00	701.00
IUUC-Mmu-063096	Mus musculus	64.31	0.00e+00	1118.00
IUUC-Mpu-065846	Mustela putorius furo	64.04	0.00e+00	1121.00
IUUC-Mlu-067992	Myotis lucifugus	67.70	0.00e+00	1091.00
IUUC-Nle-069565	Nomascus leucogenys	63.88	0.00e+00	1032.00
IUUC-Opr-070853	Ochotona princeps	61.33	0.00e+00	711.00
IUUC-Ont-071628	Oreochromis niloticus	63.51	0.00e+00	1078.00
IUUC-Ocu-074094	Oryctolagus cuniculus	64.62	0.00e+00	1124.00
IUUC-Ola-087384	Oryzias latipes	63.39	0.00e+00	1112.00
IUUC-Oga-088224	Otolemur garnettii	64.27	0.00e+00	1123.00
IUUC-Oar-090043	Ovis aries	62.82	0.00e+00	1061.00
IUUC-Ptr-090852	Pan troglodytes	64.30	0.00e+00	1117.00
IUUC-Pan-092787	Papio anubis	64.30	0.00e+00	1122.00
IUUC-Psi-092986	Pelodiscus sinensis	65.56	0.00e+00	891.00
IUUC-Pma-094416	Petromyzon marinus	39.50	4.00e-165	575.00
IUUC-Pfo-096720	Poecilia formosa	64.38	0.00e+00	1125.00
IUUC-Pab-098325	Pongo abelii	59.61	0.00e+00	796.00
IUUC-Pca-100885	Procavia capensis	58.69	0.00e+00	845.00
IUUC-Pva-102829	Pteropus vampyrus	52.78	0.00e+00	850.00
IUUC-Rno-104882	Rattus norvegicus	64.39	0.00e+00	1123.00
IUUC-Sha-106811	Sarcophilus harrisii	70.28	7.00e-93	333.00
IUUC-Sar-113020	Sorex araneus	69.60	2.00e-172	599.00
IUUC-Ssc-115436	Sus scrofa	52.35	8.00e-80	290.00
IUUC-Tgu-117042	Taeniopygia guttata	70.46	0.00e+00	1194.00
IUUC-Tru-118419	Takifugu rubripes	63.03	0.00e+00	1048.00
IUUC-Tsy-118829	Tarsius syrichta	58.25	1.00e-174	606.00
IUUC-Tni-120410	Tetraodon nigroviridis	51.64	0.00e+00	803.00
IUUC-Tbe-128113	Tupaia belangeri	80.42	0.00e+00	649.00
IUUC-Ttr-128167	Tursiops truncatus	60.72	0.00e+00	1033.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence