iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046339

UUCD1 version

UUC-HoS-01078

Ensembl Protein ID

ENSP00000393596.2

UniProt Accession

Q9NR09; Q9ULD1; BIRC6_HUMAN

Genbank Protein ID

AAF75772.1; BAA86603.2

Protein Name

Baculoviral IAP repeat-containing protein 6; BIR repeat-containing ubiquitin-conjugating enzyme; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon

Genbank Nucleotide ID

AC079837; AB033115

Gene Name

BIRC6; KIAA1289

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000115760.13	ENST00000421745.6	ENSP00000393596.2
ENSG00000115760.13	ENST00000444173.5	ENSP00000413090.1
ENSG00000115760.13	ENST00000431454.2	ENSP00000393590.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	16601304

Classification

Family	E-value	Score	Start	End
E2/UBC	9.90e-34	117.7	4577	4733

Active Site

Position(s)	Description	Evidence
4625	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp....egisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.....ifhPnvyenGkv 81
           Rl++e+ +l+++ p    +++++++++e  l+ ++vli+Gp+dtpY++g+F+++++fp+dYP++PP v+++t+     +f+Pn+y++Gkv
   Q: 4577 RLAQEAVTLSTSLPlsssSSVFVRCDEE-RLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTgghsvRFNPNLYNDGKV 4665
           8999999999998877768899999999.6************************************************************ PP
   S: 82   Clsilk.....eeekWsp.alsvesvllsiqsll..aepnpesplneeaa...ellkknreeykkkvre 139
           Clsil+     +eekW+p ++s+ +vl+s+qsl+  aep++++p +e+++   + ++++re y+ ++r+
   Q: 4666 CLSILNtwhgrPEEKWNPqTSSFLQVLVSVQSLIlvAEPYFNEPGYERSRgtpSGTQSSRE-YDGNIRQ 4733
           *****7788889******8899***********999***********99866555666655.9998875 PP

Organism

Homo sapiens

Functional Description
(View)

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Protein Sequence
(Fasta)

MVTGGGAAPP GTVTEPLPSV IVLSAGRKMA AAAAAASGPG CSSAAGAGAA GVSEWLVLRD 60
GCMHCDADGL HSLSYHPALN AILAVTSRGT IKVIDGTSGA TLQASALSAK PGGQVKCQYI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCTGCTTC TCCCCCTCTC CCGTCAGCCT CCCTCCGAGT TTGGCCCCTC CGGCCGGGCG 60
ATCGACGTTC CGCGTGCGTG CGGGCGCCTG ACTTCACTTC CGGCTAACGC GCTCGGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0789--Thiol protease inhibitor
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001370--BIR_rpt
IPR022103--BIRC6
IPR008979--Galactose-bd-like
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50143--BIR_REPEAT_2
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00653--BIR
PF12356--BIRC6
PF00179--UQ_con

SMART

SM00238--BIR

Gene Ontology

GO:0005768--C:endosome
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0000922--C:spindle pole
GO:0005802--C:trans-Golgi network
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0051301--P:cell division
GO:0060711--P:labyrinthine layer development
GO:0007067--P:mitotic nuclear division
GO:0043066--P:negative regulation of apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0008284--P:positive regulation of cell proliferation
GO:0006468--P:protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0032465--P:regulation of cytokinesis
GO:0060712--P:spongiotrophoblast layer development

KEGG

hsa:57448

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001583	Ailuropoda melanoleuca	97.85	0.00e+00	8819.00
IUUC-Atr-003108	Amborella trichopoda	42.86	4.00e-45	175.00
IUUC-Apl-004144	Anas platyrhynchos	92.59	0.00e+00	5652.00
IUUC-Aca-005257	Anolis carolinensis	89.74	0.00e+00	8076.00
IUUC-Ath-007217	Arabidopsis thaliana	37.08	7.00e-44	172.00
IUUC-Ame-011337	Astyanax mexicanus	77.99	0.00e+00	6698.00
IUUC-Bta-012501	Bos taurus	96.74	0.00e+00	8594.00
IUUC-Bdi-014931	Brachypodium distachyon	38.06	3.00e-46	179.00
IUUC-Bol-015976	Brassica oleracea	46.33	1.00e-45	177.00
IUUC-Bra-017967	Brassica rapa	46.33	5.00e-46	178.00
IUUC-Cel-018661	Caenorhabditis elegans	36.76	3.00e-79	289.00
IUUC-Cja-018746	Callithrix jacchus	98.66	0.00e+00	8810.00
IUUC-Cfa-020170	Canis familiaris	97.92	0.00e+00	8621.00
IUUC-Cpo-022138	Cavia porcellus	97.56	0.00e+00	5846.00
IUUC-Cre-022768	Chlamydomonas reinhardtii	44.69	1.00e-44	172.00
IUUC-Csa-023927	Chlorocebus sabaeus	99.12	0.00e+00	8811.00
IUUC-Cho-024890	Choloepus hoffmanni	94.61	0.00e+00	1949.00
IUUC-Cne-026995	Cryptococcus neoformans	42.62	2.00e-37	151.00
IUUC-Dre-027941	Danio rerio	78.58	0.00e+00	5336.00
IUUC-Dno-028913	Dasypus novemcinctus	95.74	0.00e+00	8572.00
IUUC-Dor-030715	Dipodomys ordii	94.93	0.00e+00	1954.00
IUUC-Dse-031232	Dothistroma septosporum	44.51	5.00e-38	153.00
IUUC-Dme-031592	Drosophila melanogaster	52.78	0.00e+00	674.00
IUUC-Ete-032587	Echinops telfairi	78.37	0.00e+00	2088.00
IUUC-Eca-033819	Equus caballus	97.53	0.00e+00	8663.00
IUUC-Eeu-034863	Erinaceus europaeus	85.77	0.00e+00	2542.00
IUUC-Fca-035505	Felis catus	95.02	0.00e+00	8413.00
IUUC-Fal-037318	Ficedula albicollis	92.39	0.00e+00	8267.00
IUUC-Gmo-039521	Gadus morhua	81.18	0.00e+00	1689.00
IUUC-Ggr-040040	Gaeumannomyces graminis	47.06	2.00e-33	138.00
IUUC-Gga-040728	Gallus gallus	92.18	0.00e+00	8172.00
IUUC-Gac-042251	Gasterosteus aculeatus	84.31	0.00e+00	1791.00
IUUC-Ggo-045562	Gorilla gorilla	97.42	0.00e+00	1615.00
IUUC-Hvu-047441	Hordeum vulgare	46.70	4.00e-47	182.00
IUUC-Itr-048099	Ictidomys tridecemlineatus	97.65	0.00e+00	2714.00
IUUC-Lch-050164	Latimeria chalumnae	85.74	0.00e+00	7546.00
IUUC-Lpe-051294	Leersia perrieri	40.23	3.00e-47	182.00
IUUC-Loc-052800	Lepisosteus oculatus	84.93	0.00e+00	7521.00
IUUC-Laf-054034	Loxodonta africana	96.58	0.00e+00	8627.00
IUUC-Mcc-055267	Macaca mulatta	99.08	0.00e+00	8794.00
IUUC-Meu-056461	Macropus eugenii	93.25	0.00e+00	1237.00
IUUC-Mpo-057396	Magnaporthe poae	49.03	2.00e-34	141.00
IUUC-Mtr-057797	Medicago truncatula	39.52	4.00e-47	182.00
IUUC-Mla-059114	Melampsora laricipopulina	28.31	4.00e-40	160.00
IUUC-Mga-059594	Meleagris gallopavo	92.05	0.00e+00	7759.00
IUUC-Mmr-061179	Microcebus murinus	97.76	0.00e+00	8665.00
IUUC-Mdo-062990	Monodelphis domestica	93.70	0.00e+00	8238.00
IUUC-Mmu-063825	Mus musculus	94.96	0.00e+00	8467.00
IUUC-Mac-064881	Musa acuminata	43.41	7.00e-42	164.00
IUUC-Mpu-065908	Mustela putorius furo	97.33	0.00e+00	5566.00
IUUC-Mlu-067106	Myotis lucifugus	96.47	0.00e+00	8620.00
IUUC-Nle-069347	Nomascus leucogenys	99.50	0.00e+00	8826.00
IUUC-Opr-070799	Ochotona princeps	87.51	0.00e+00	2550.00
IUUC-Ont-072046	Oreochromis niloticus	79.06	0.00e+00	6802.00
IUUC-Oan-073415	Ornithorhynchus anatinus	93.14	0.00e+00	3391.00
IUUC-Ocu-074556	Oryctolagus cuniculus	97.18	0.00e+00	8604.00
IUUC-Oba-075602	Oryza barthii	39.55	5.00e-40	159.00
IUUC-Obr-076463	Oryza brachyantha	38.81	8.00e-47	180.00
IUUC-Ogl-077040	Oryza glaberrima	39.55	5.00e-40	159.00
IUUC-Ogu-077966	Oryza glumaepatula	39.31	2.00e-47	183.00
IUUC-Oin-079561	Oryza indica	39.55	5.00e-40	159.00
IUUC-Olo-080416	Oryza longistaminata	41.04	1.00e-40	162.00
IUUC-Ome-081384	Oryza meridionalis	39.55	6.00e-40	158.00
IUUC-Oni-082326	Oryza nivara	39.46	3.00e-47	182.00
IUUC-Opu-083659	Oryza punctata	38.81	2.00e-46	180.00
IUUC-Oru-084622	Oryza rufipogon	39.55	5.00e-40	159.00
IUUC-Osa-085920	Oryza sativa	39.55	5.00e-40	159.00
IUUC-Ola-087459	Oryzias latipes	82.68	0.00e+00	2881.00
IUUC-Oga-088251	Otolemur garnettii	95.33	0.00e+00	8239.00
IUUC-Oar-090367	Ovis aries	96.55	0.00e+00	8601.00
IUUC-Ptr-091512	Pan troglodytes	99.75	0.00e+00	8837.00
IUUC-Pan-092222	Papio anubis	98.37	0.00e+00	8781.00
IUUC-Pma-094574	Petromyzon marinus	61.06	0.00e+00	3000.00
IUUC-Ppa-095592	Physcomitrella patens	29.45	4.00e-55	210.00
IUUC-Pfo-097086	Poecilia formosa	77.73	0.00e+00	6830.00
IUUC-Pab-098390	Pongo abelii	97.75	0.00e+00	8580.00
IUUC-Pop-099782	Populus trichocarpa	43.96	1.00e-41	164.00
IUUC-Pca-101036	Procavia capensis	88.93	0.00e+00	4141.00
IUUC-Ppe-101722	Prunus persica	44.51	4.00e-43	169.00
IUUC-Pva-103053	Pteropus vampyrus	92.89	0.00e+00	3617.00
IUUC-Pte-104333	Pyrenophora teres	41.29	1.00e-43	172.00
IUUC-Pyt-104498	Pyrenophora triticirepentis	39.39	4.00e-44	173.00
IUUC-Rno-106049	Rattus norvegicus	95.71	0.00e+00	6962.00
IUUC-Sha-107483	Sarcophilus harrisii	90.93	0.00e+00	7786.00
IUUC-Smo-108915	Selaginella moellendorffii	42.96	2.00e-44	172.00
IUUC-Sly-110929	Solanum lycopersicum	38.55	2.00e-46	180.00
IUUC-Stu-112554	Solanum tuberosum	38.96	1.00e-46	181.00
IUUC-Sar-112965	Sorex araneus	86.29	0.00e+00	1807.00
IUUC-Sbi-113880	Sorghum bicolor	35.99	2.00e-44	173.00
IUUC-Ssc-115927	Sus scrofa	97.78	0.00e+00	6003.00
IUUC-Tgu-117132	Taeniopygia guttata	92.44	0.00e+00	8202.00
IUUC-Tru-118115	Takifugu rubripes	75.92	0.00e+00	6672.00
IUUC-Tsy-118899	Tarsius syrichta	95.34	0.00e+00	5097.00
IUUC-Tni-120891	Tetraodon nigroviridis	74.80	0.00e+00	6637.00
IUUC-Tae-125407	Triticum aestivum	47.25	3.00e-47	183.00
IUUC-Tur-126479	Triticum urartu	46.41	2.00e-43	170.00
IUUC-Tme-126930	Tuber melanosporum	42.60	8.00e-48	186.00
IUUC-Tbe-127630	Tupaia belangeri	94.41	0.00e+00	1560.00
IUUC-Ttr-128629	Tursiops truncatus	95.61	0.00e+00	8486.00
IUUC-Vpa-130310	Vicugna pacos	96.74	0.00e+00	8361.00
IUUC-Xtr-131861	Xenopus tropicalis	83.75	0.00e+00	7264.00
IUUC-Xma-133613	Xiphophorus maculatus	77.91	0.00e+00	6815.00
IUUC-Zma-135768	Zea mays	35.90	4.00e-45	177.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence