iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	3.20e-48	164.9	30	220

Active Site

Position(s)	Description	Evidence
204	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpek..leeseikellveeelykryekllleevveadaal 88
           Ck+Cl+e+s +++t+l+eC+++fC+ Clkqy+ l i+eg+ + i+cp++ c ++  l+e+ei++ lv  + ++ y++l++e++v++d+ +
   Q: 30   CKLCLCEQSLDKMTMLQECQCIFCTPCLKQYMVLSIREGCGSPITCPDMVCLNHgtLQETEIAC-LVPLDEFQLYQRLKFEREVHMDPLR 118
           ***************************************************9988899******.688999******************* PP
   S: 89   kwcpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekneg 176
           +wcp +dC++v+ ++  +  + + vec++c+ +fC++Ck++wHe++sC++ + ++ ++      a   + ++a +k+Cp C++yie+neg
   Q: 119  TWCPVADCQTVCHISAGDpgQPVLVECPSCHLKFCSCCKDAWHEESSCRDSQSAMPEHG-----ALFGTDADAPIKQCPVCRIYIERNEG 203
           ************99987767899999************************998877666.....899999******************** PP
   S: 177  CnhmtCakCkaefCwlC 193
           C++m+C++Ck++fCw+C
   Q: 204  CAQMMCKNCKHTFCWYC 220
           ***************** PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity).

Protein Sequence
(Fasta)

MDSVDGLQCL TMTAENPPSG DLIPAPLVTC KLCLCEQSLD KMTMLQECQC IFCTPCLKQY 60
MVLSIREGCG SPITCPDMVC LNHGTLQETE IACLVPLDEF QLYQRLKFER EVHMDPLRTW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCAGGGT GCAACGGCCG CAGGCCGCTG GACTGAGCCA CGGGATGGTA GCTAGGAGAT 60
TGGAAAGCCT TTGATGCCAG AAGATTCTGG CTGGAGACGC TGACAACCCA GCCCTGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0031966--C:mitochondrial membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mmu:218215

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001257	Ailuropoda melanoleuca	86.14	1.00e-155	541.00
IUUC-Apl-004112	Anas platyrhynchos	79.41	2.00e-122	431.00
IUUC-Aca-004533	Anolis carolinensis	79.93	3.00e-132	464.00
IUUC-Bta-012641	Bos taurus	87.50	6.00e-156	543.00
IUUC-Cja-019626	Callithrix jacchus	76.49	7.00e-132	462.00
IUUC-Cfa-020702	Canis familiaris	86.14	4.00e-155	540.00
IUUC-Cpo-022147	Cavia porcellus	88.45	8.00e-158	549.00
IUUC-Csa-023473	Chlorocebus sabaeus	86.80	1.00e-156	545.00
IUUC-Cho-024298	Choloepus hoffmanni	84.05	7.00e-127	446.00
IUUC-Dre-028099	Danio rerio	62.41	2.00e-87	315.00
IUUC-Dno-029122	Dasypus novemcinctus	81.58	4.00e-143	500.00
IUUC-Dor-030669	Dipodomys ordii	89.70	8.00e-125	439.00
IUUC-Ete-033141	Echinops telfairi	74.59	1.00e-119	422.00
IUUC-Eca-034360	Equus caballus	87.79	7.00e-157	546.00
IUUC-Eeu-034538	Erinaceus europaeus	69.01	4.00e-80	290.00
IUUC-Fca-036055	Felis catus	85.15	2.00e-153	534.00
IUUC-Fal-037339	Ficedula albicollis	75.99	9.00e-125	439.00
IUUC-Gmo-038780	Gadus morhua	60.44	8.00e-84	303.00
IUUC-Gga-040256	Gallus gallus	78.15	7.00e-126	443.00
IUUC-Gac-042127	Gasterosteus aculeatus	60.85	9.00e-87	313.00
IUUC-Ggo-044867	Gorilla gorilla	88.12	5.00e-158	550.00
IUUC-Hsa-046928	Homo sapiens	87.79	1.00e-157	548.00
IUUC-Hvu-047484	Hordeum vulgare	29.80	1.00e-15	77.40
IUUC-Itr-048250	Ictidomys tridecemlineatus	90.16	3.00e-101	360.00
IUUC-Lch-050168	Latimeria chalumnae	72.88	3.00e-126	444.00
IUUC-Lpe-051649	Leersia perrieri	27.59	1.00e-15	79.00
IUUC-Loc-052150	Lepisosteus oculatus	59.42	8.00e-86	310.00
IUUC-Laf-053967	Loxodonta africana	88.45	3.00e-159	554.00
IUUC-Mcc-055898	Macaca mulatta	86.80	1.00e-156	545.00
IUUC-Meu-056628	Macropus eugenii	94.87	9.00e-43	166.00
IUUC-Mtr-057989	Medicago truncatula	27.94	1.00e-17	83.60
IUUC-Mga-059820	Meleagris gallopavo	77.04	4.00e-124	437.00
IUUC-Mmr-060680	Microcebus murinus	86.47	3.00e-154	537.00
IUUC-Mdo-062839	Monodelphis domestica	81.91	3.00e-146	510.00
IUUC-Mac-065414	Musa acuminata	28.44	4.00e-18	85.50
IUUC-Mpu-065973	Mustela putorius furo	85.48	2.00e-154	538.00
IUUC-Mlu-067112	Myotis lucifugus	87.46	5.00e-147	513.00
IUUC-Nle-069795	Nomascus leucogenys	87.79	1.00e-157	548.00
IUUC-Opr-070390	Ochotona princeps	80.53	6.00e-137	479.00
IUUC-Ont-072329	Oreochromis niloticus	63.18	2.00e-87	315.00
IUUC-Oan-072980	Ornithorhynchus anatinus	80.43	2.00e-130	458.00
IUUC-Ocu-073845	Oryctolagus cuniculus	87.79	9.00e-157	545.00
IUUC-Ola-086872	Oryzias latipes	59.55	8.00e-82	296.00
IUUC-Oga-088954	Otolemur garnettii	87.79	1.00e-155	542.00
IUUC-Oar-089879	Ovis aries	87.50	6.00e-156	543.00
IUUC-Ptr-090685	Pan troglodytes	87.79	1.00e-157	548.00
IUUC-Pan-092086	Papio anubis	87.13	9.00e-157	545.00
IUUC-Psi-093481	Pelodiscus sinensis	78.55	2.00e-132	464.00
IUUC-Pfo-096065	Poecilia formosa	62.21	3.00e-88	318.00
IUUC-Pab-098031	Pongo abelii	87.79	6.00e-157	546.00
IUUC-Pca-100936	Procavia capensis	86.14	2.00e-153	534.00
IUUC-Pva-102864	Pteropus vampyrus	77.89	3.00e-134	471.00
IUUC-Rno-105503	Rattus norvegicus	98.01	1.00e-166	578.00
IUUC-Sha-107425	Sarcophilus harrisii	82.24	3.00e-147	514.00
IUUC-Ssc-115458	Sus scrofa	85.34	5.00e-143	500.00
IUUC-Tgu-117226	Taeniopygia guttata	76.34	4.00e-126	444.00
IUUC-Tru-118362	Takifugu rubripes	63.91	6.00e-91	327.00
IUUC-Tsy-119255	Tarsius syrichta	88.12	1.00e-158	551.00
IUUC-Tni-120140	Tetraodon nigroviridis	60.29	2.00e-86	311.00
IUUC-Tae-124420	Triticum aestivum	30.30	5.00e-17	82.80
IUUC-Tbe-127306	Tupaia belangeri	87.79	4.00e-156	543.00
IUUC-Ttr-128923	Tursiops truncatus	86.51	2.00e-142	498.00
IUUC-Vpa-130148	Vicugna pacos	86.47	7.00e-155	539.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence