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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063364
UUCD1 version UUC-MuM-00004
Ensembl Protein ID ENSMUSP00000113035.1
UniProt Accession O70263; O70264; Q8BRI8; Q8CFR3; LNX1_MOUSE
Genbank Protein ID AAC40075.1; AAC40076.1; BAC31789.1; AAH40367.1
Protein Name E3 ubiquitin-protein ligase LNX; Ligand of Numb protein X 1; Ligand of Numb-binding protein 1; Numb-binding protein 1; RING-type E3 ubiquitin transferase LNX
Genbank Nucleotide ID AF034745; AF034746; AK044127; BC040367
Gene Name Lnx1; Lnx
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029228.15 ENSMUST00000039744.12 ENSMUSP00000040098.6
ENSMUSG00000029228.15 ENSMUST00000127396.7 ENSMUSP00000120886.1
ENSMUSG00000029228.15 ENSMUST00000121690.7 ENSMUSP00000113565.1
ENSMUSG00000029228.15 ENSMUST00000117388.7 ENSMUSP00000113035.1
ENSMUSG00000029228.15 ENSMUST00000140084.3 ENSMUSP00000117935.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17553932
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0018 19.9 45 83
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+ + d pl +pCgH++++ Cl ++         ++ CP++r
   Q: 45   CHICLQALLD-PLDTPCGHTYCTLCLTNF------LVEKDFCPVDR 83
           99********.99*************888......66666699986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
 Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
Protein Sequence
(Fasta)
MNQPDLADDP DPSPEPLCIV CGQNHSPEEN HFYTYTEDVD DDLICHICLQ ALLDPLDTPC 60
GHTYCTLCLT NFLVEKDFCP VDRKPVVLQH CKKSSILVNK LLNKLLVTCP FTEHCTEVLQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063364|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGCCACCTG TACACCGAAG TTGAGACCGG TCACAGCTCA GGCGGCCCTA GACGCTTCTG 60
GCACAGGGAT GGAGGCTGGC TGGTCACTGC TGCTTTGAAA GTCCCAAACA TCTTTGAACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063364|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001478--PDZ
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50106--PDZ
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00595--PDZ
SMART

SM00228--PDZ
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030165--F:PDZ domain binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051260--P:protein homooligomerization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:16924
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002005 Ailuropoda melanoleuca 86.03 0.00e+00 1191.00
IUUC-Apl-003561 Anas platyrhynchos 71.51 0.00e+00 989.00
IUUC-Aca-005346 Anolis carolinensis 71.12 0.00e+00 1034.00
IUUC-Bta-012970 Bos taurus 86.75 0.00e+00 1216.00
IUUC-Cja-019412 Callithrix jacchus 86.75 0.00e+00 1243.00
IUUC-Cfa-020735 Canis familiaris 86.75 0.00e+00 1263.00
IUUC-Cpo-022198 Cavia porcellus 77.41 0.00e+00 1047.00
IUUC-Dre-028841 Danio rerio 49.25 6.00e-29 119.00
IUUC-Dno-028889 Dasypus novemcinctus 87.95 0.00e+00 1272.00
IUUC-Dor-030810 Dipodomys ordii 79.06 0.00e+00 927.00
IUUC-Fca-036264 Felis catus 87.47 0.00e+00 1204.00
IUUC-Fal-037198 Ficedula albicollis 71.80 0.00e+00 1046.00
IUUC-Gga-040766 Gallus gallus 67.71 0.00e+00 994.00
IUUC-Ggo-045057 Gorilla gorilla 87.98 0.00e+00 1274.00
IUUC-Hsa-046470 Homo sapiens 87.98 0.00e+00 1300.00
IUUC-Itr-048393 Ictidomys tridecemlineatus 89.71 0.00e+00 1328.00
IUUC-Lch-050081 Latimeria chalumnae 63.66 0.00e+00 915.00
IUUC-Loc-052884 Lepisosteus oculatus 61.74 0.00e+00 895.00
IUUC-Laf-054498 Loxodonta africana 88.52 0.00e+00 1275.00
IUUC-Meu-056401 Macropus eugenii 53.29 4.00e-139 488.00
IUUC-Mga-059504 Meleagris gallopavo 72.08 0.00e+00 1030.00
IUUC-Mmr-060696 Microcebus murinus 62.46 0.00e+00 759.00
IUUC-Mdo-062731 Monodelphis domestica 80.08 0.00e+00 1156.00
IUUC-Mpu-066626 Mustela putorius furo 86.48 0.00e+00 1250.00
IUUC-Mlu-068207 Myotis lucifugus 86.31 0.00e+00 1217.00
IUUC-Nle-069304 Nomascus leucogenys 88.52 0.00e+00 1305.00
IUUC-Opr-071080 Ochotona princeps 74.23 0.00e+00 1048.00
IUUC-Ont-072002 Oreochromis niloticus 58.29 0.00e+00 788.00
IUUC-Ola-086477 Oryzias latipes 57.60 0.00e+00 820.00
IUUC-Oga-089142 Otolemur garnettii 85.13 0.00e+00 1230.00
IUUC-Oar-090359 Ovis aries 86.20 0.00e+00 1230.00
IUUC-Ptr-090797 Pan troglodytes 88.11 0.00e+00 1300.00
IUUC-Pan-091910 Papio anubis 87.43 0.00e+00 1286.00
IUUC-Psi-093386 Pelodiscus sinensis 73.40 0.00e+00 1037.00
IUUC-Pfo-096370 Poecilia formosa 58.16 0.00e+00 788.00
IUUC-Pab-097761 Pongo abelii 88.49 0.00e+00 1005.00
IUUC-Pva-102443 Pteropus vampyrus 87.73 0.00e+00 953.00
IUUC-Rno-106030 Rattus norvegicus 95.47 0.00e+00 1402.00
IUUC-Sha-107609 Sarcophilus harrisii 78.07 0.00e+00 1134.00
IUUC-Sar-113333 Sorex araneus 84.79 0.00e+00 1236.00
IUUC-Ssc-116222 Sus scrofa 78.56 0.00e+00 1102.00
IUUC-Tgu-117019 Taeniopygia guttata 72.18 0.00e+00 1019.00
IUUC-Tru-118481 Takifugu rubripes 60.33 0.00e+00 834.00
IUUC-Tni-119796 Tetraodon nigroviridis 52.82 0.00e+00 699.00
IUUC-Tbe-127538 Tupaia belangeri 84.84 0.00e+00 1211.00
IUUC-Ttr-128787 Tursiops truncatus 84.86 0.00e+00 1177.00
IUUC-Xtr-132476 Xenopus tropicalis 63.11 0.00e+00 843.00
Created Date 25-Jun-2017

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