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Tag Content
iUUCD ID IUUC-Dre-028261
UUCD1 version UUC-DaR-00995
Ensembl Protein ID ENSDARP00000139883.1
UniProt Accession Q804S5; Q8JHG3; MIB1_DANRE
Genbank Protein ID AAO37830.1; AAM34677.1
Protein Name E3 ubiquitin-protein ligase mib1; Protein mind bomb; RING-type E3 ubiquitin transferase mib1
Genbank Nucleotide ID AF537301; AF506233
Gene Name mib1; mib
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000102184.2 ENSDART00000158602.2 ENSDARP00000135215.2
ENSDARG00000102184.2 ENSDART00000163507.2 ENSDARP00000132570.2
ENSDARG00000102184.2 ENSDART00000173418.1 ENSDARP00000142055.1
ENSDARG00000102184.2 ENSDART00000171170.1 ENSDARP00000141673.1
ENSDARG00000102184.2 ENSDART00000165634.1 ENSDARP00000139883.1
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19056830; 17196985
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 91.76 0.00e+00 1943.00 IUUC-Hsa-046439
E3 activity/RING/RING 91.76 0.00e+00 1943.00 IUUC-Mmu-063520
Organism Danio rerio
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development.
 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development.
Protein Sequence
(Fasta)
MTTGRNNRVM MEGVGARVIR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV VWDNGTAANY 60
RCSGAYDVRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC AECTNYDLCT TCYHGDKHHL 120
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Protein Fasta Sequence


>IUUC-Dre-028261|E3,RING|Danio rerio
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Nucleotide Sequence
(Fasta)
TCATCCGTGG CGTTGTGGCT GCTGTTTACA GACCCGAGCG TGCGTTTGTT TCGAGCATGA 60
AGGACTGCGC TTTCTTCACC TACCGCCATT CATTCAGGAA TTATATCTGA ACTCGAGTAA 120
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Nucleotide Fasta Sequence


>IUUC-Dre-028261|E3,RING|Danio rerio
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Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR010606--Mib_Herc2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR000433--Znf_ZZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS51416--MIB_HERC2
PS50089--ZF_RING_2
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF12796--Ank_2
PF06701--MIB_HERC2
PF00569--ZZ
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00184--RING
SM00291--ZnF_ZZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0030139--C:endocytic vesicle
GO:0005815--C:microtubule organizing center
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0042803--F:protein homodimerization activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0048899--P:anterior lateral line development
GO:0001568--P:blood vessel development
GO:0048514--P:blood vessel morphogenesis
GO:0007420--P:brain development
GO:0007417--P:central nervous system development
GO:0007368--P:determination of left/right symmetry
GO:0048066--P:developmental pigmentation
GO:0021536--P:diencephalon development
GO:0048546--P:digestive tract morphogenesis
GO:0031076--P:embryonic camera-type eye development
GO:0009880--P:embryonic pattern specification
GO:0001885--P:endothelial cell development
GO:0002064--P:epithelial cell development
GO:0021508--P:floor plate formation
GO:0048859--P:formation of anatomical boundary
GO:0048699--P:generation of neurons
GO:0010001--P:glial cell differentiation
GO:0021986--P:habenula development
GO:0035315--P:hair cell differentiation
GO:0007507--P:heart development
GO:0060218--P:hematopoietic stem cell differentiation
GO:0030097--P:hemopoiesis
GO:0030902--P:hindbrain development
GO:0060113--P:inner ear receptor cell differentiation
GO:0048892--P:lateral line nerve development
GO:0030318--P:melanocyte differentiation
GO:0003407--P:neural retina development
GO:0022008--P:neurogenesis
GO:0048666--P:neuron development
GO:0030182--P:neuron differentiation
GO:0048663--P:neuron fate commitment
GO:0048665--P:neuron fate specification
GO:0007219--P:Notch signaling pathway
GO:0060035--P:notochord cell development
GO:0030903--P:notochord development
GO:0003408--P:optic cup formation involved in camera-type eye development
GO:0071599--P:otic vesicle development
GO:0050931--P:pigment cell differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0031398--P:positive regulation of protein ubiquitination
GO:0048916--P:posterior lateral line development
GO:0039022--P:pronephric duct development
GO:0048793--P:pronephros development
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0045685--P:regulation of glial cell differentiation
GO:0045664--P:regulation of neuron differentiation
GO:0008593--P:regulation of Notch signaling pathway
GO:0002090--P:regulation of receptor internalization
GO:0048259--P:regulation of receptor-mediated endocytosis
GO:0021654--P:rhombomere boundary formation
GO:0021546--P:rhombomere development
GO:0001756--P:somitogenesis
GO:0021519--P:spinal cord association neuron specification
GO:0021510--P:spinal cord development
GO:0021520--P:spinal cord motor neuron cell fate specification
GO:0061195--P:taste bud formation
GO:0061551--P:trigeminal ganglion development
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0001570--P:vasculogenesis
GO:0021514--P:ventral spinal cord interneuron differentiation
GO:0021521--P:ventral spinal cord interneuron specification
KEGG dre:352910
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001993 Ailuropoda melanoleuca 92.17 0.00e+00 1893.00
IUUC-Apl-003867 Anas platyrhynchos 92.13 0.00e+00 1918.00
IUUC-Aca-004471 Anolis carolinensis 92.05 0.00e+00 1941.00
IUUC-Ang-009817 Aspergillus niger 35.54 4.00e-30 125.00
IUUC-Ame-011923 Astyanax mexicanus 93.79 0.00e+00 1932.00
IUUC-Bta-012972 Bos taurus 91.86 0.00e+00 1941.00
IUUC-Cja-019044 Callithrix jacchus 87.47 0.00e+00 1725.00
IUUC-Cfa-020049 Canis familiaris 89.94 0.00e+00 1884.00
IUUC-Cpo-022228 Cavia porcellus 91.64 0.00e+00 1785.00
IUUC-Csa-023228 Chlorocebus sabaeus 91.86 0.00e+00 1940.00
IUUC-Cho-024456 Choloepus hoffmanni 81.74 0.00e+00 794.00
IUUC-Cin-025506 Ciona intestinalis 71.81 0.00e+00 879.00
IUUC-Csv-026037 Ciona savignyi 61.07 0.00e+00 1305.00
IUUC-Dno-029816 Dasypus novemcinctus 92.05 0.00e+00 1942.00
IUUC-Dor-030678 Dipodomys ordii 73.27 0.00e+00 1348.00
IUUC-Dme-031616 Drosophila melanogaster 71.69 0.00e+00 1184.00
IUUC-Ete-032436 Echinops telfairi 89.74 5.00e-128 452.00
IUUC-Eca-033837 Equus caballus 91.84 0.00e+00 1789.00
IUUC-Eeu-034896 Erinaceus europaeus 78.80 0.00e+00 646.00
IUUC-Fca-036568 Felis catus 91.89 0.00e+00 1776.00
IUUC-Fal-037586 Ficedula albicollis 91.76 0.00e+00 1939.00
IUUC-Gmo-038802 Gadus morhua 95.53 0.00e+00 2019.00
IUUC-Gga-040131 Gallus gallus 91.86 0.00e+00 1941.00
IUUC-Gac-042052 Gasterosteus aculeatus 96.12 0.00e+00 2063.00
IUUC-Ggo-044970 Gorilla gorilla 91.76 0.00e+00 1939.00
IUUC-Hsa-046439 Homo sapiens 91.76 0.00e+00 1939.00
IUUC-Itr-048363 Ictidomys tridecemlineatus 88.60 0.00e+00 757.00
IUUC-Lch-049434 Latimeria chalumnae 86.23 0.00e+00 1787.00
IUUC-Loc-052278 Lepisosteus oculatus 91.69 0.00e+00 1914.00
IUUC-Laf-054292 Loxodonta africana 91.00 0.00e+00 1770.00
IUUC-Meu-056752 Macropus eugenii 71.47 3.00e-137 483.00
IUUC-Mga-059408 Meleagris gallopavo 91.48 0.00e+00 1799.00
IUUC-Mmr-061628 Microcebus murinus 91.96 0.00e+00 1941.00
IUUC-Mdo-062055 Monodelphis domestica 91.96 0.00e+00 1942.00
IUUC-Mmu-063520 Mus musculus 91.76 0.00e+00 1972.00
IUUC-Mpu-065864 Mustela putorius furo 91.86 0.00e+00 1941.00
IUUC-Mlu-067802 Myotis lucifugus 91.74 0.00e+00 1788.00
IUUC-Nle-069568 Nomascus leucogenys 90.70 0.00e+00 1881.00
IUUC-Opr-071018 Ochotona princeps 71.85 5.00e-161 561.00
IUUC-Ont-072079 Oreochromis niloticus 97.56 0.00e+00 2083.00
IUUC-Oan-073346 Ornithorhynchus anatinus 94.80 0.00e+00 1272.00
IUUC-Ocu-073932 Oryctolagus cuniculus 91.96 0.00e+00 1942.00
IUUC-Ola-087184 Oryzias latipes 97.28 0.00e+00 2046.00
IUUC-Oga-089002 Otolemur garnettii 92.26 0.00e+00 1949.00
IUUC-Oar-089440 Ovis aries 91.84 0.00e+00 1794.00
IUUC-Ptr-090690 Pan troglodytes 91.28 0.00e+00 1920.00
IUUC-Pan-092295 Papio anubis 91.86 0.00e+00 1940.00
IUUC-Psi-093118 Pelodiscus sinensis 91.67 0.00e+00 1929.00
IUUC-Pma-094438 Petromyzon marinus 88.28 0.00e+00 686.00
IUUC-Pfo-096302 Poecilia formosa 91.58 0.00e+00 1910.00
IUUC-Pab-097804 Pongo abelii 89.56 0.00e+00 1035.00
IUUC-Pca-101028 Procavia capensis 81.82 0.00e+00 776.00
IUUC-Pva-102890 Pteropus vampyrus 87.02 0.00e+00 872.00
IUUC-Rno-105470 Rattus norvegicus 91.38 0.00e+00 1934.00
IUUC-Sha-106650 Sarcophilus harrisii 91.91 0.00e+00 1872.00
IUUC-Sar-113247 Sorex araneus 80.95 0.00e+00 776.00
IUUC-Ssc-115706 Sus scrofa 91.96 0.00e+00 1942.00
IUUC-Tgu-116863 Taeniopygia guttata 91.67 0.00e+00 1935.00
IUUC-Tru-117733 Takifugu rubripes 97.19 0.00e+00 2048.00
IUUC-Tsy-119313 Tarsius syrichta 89.99 0.00e+00 1307.00
IUUC-Tni-120601 Tetraodon nigroviridis 94.57 0.00e+00 1973.00
IUUC-Tbe-127979 Tupaia belangeri 83.18 0.00e+00 1389.00
IUUC-Ttr-128673 Tursiops truncatus 91.86 0.00e+00 1939.00
IUUC-Vpa-130332 Vicugna pacos 88.99 0.00e+00 1843.00
IUUC-Xtr-132423 Xenopus tropicalis 91.28 0.00e+00 1934.00
Created Date 25-Jun-2017

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