iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004314

UUCD1 version

UUC-AnC-01007

Ensembl Protein ID

ENSACAP00000001669.2

UniProt Accession

G1K9U0; G1K9U0_ANOCA

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000001581.2	ENSACAT00000001709.2	ENSACAP00000001669.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-80	271.2	197	837

Active Site

Position(s)	Description	Evidence
206	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
772	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp...........kepkgellkslqklfeelwkskkkavs 69
           +Gl+NlgNtC++N+vLQ Ls++p lrell+e                 e p            ++  +l+ ++ ++++ ++++kk+ v+
   Q: 197  KGLSNLGNTCFFNAVLQNLSQTPVLRELLKEvkmadytitI-------EPPefsitepvvitLDQPRPLTLAMCDFLTDMQETKKGTVT 278
           5******************************7644443332.......2225555555777788888********************** PP
   S: 70   prellkalkkeaee..fsgyeqqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqg 148
           p+el+++++k+ +   f+gy+qqD+qE+l++lld++++e  +          n++ ++   e+++ +++++e++k k ++++++++F+g
   Q: 279  PKELFSQVCKKRRAirFKGYQQQDSQELLRYLLDGMRTEEVQricagifkALNNSADK---ENEELKKKIKEYEKRKITQTFVDRIFGG 364
           ********9999886688******************9998666888755422222222...2333455669999*************** PP
   S: 149  qlksqikclecdnvssreepfldlslpvpgkeetkke.................................................... 185
           +l+s+i+c+ec++vs  +e+fldlslpv +++  kk+                                                    
   Q: 365  ELTSTIMCEECQTVSLVHESFLDLSLPVLNDQGAKKKtvekrvkklqenemeddadniendsylkdreetpgtskhlqkkakkiakkqa 453
           ********************************988889*************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 454  knhrrqqkfqekvipltdscateknetdhissngiekaeinsevaslkqeekslnsyeqscvdqrdninghditdthnnnvnaedsgql 542
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 543  ennevgtgipseglvsvvecvnkfdnlsleedstlpvededddededcaangfhklsldeepeddtdsfselhnsklyqvvnedpetaf 631
           ***************************************************************************************** PP
   S: 186  ..............slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeq 243
                         s+ +cL +ft +e+l+++nk+ c+ c++kq                  a+k++ ++  P++L+lhLkRf  ++++
   Q: 632  ctlanreeinteesSVLHCLYQFTHNEKLCENNKLLCDVCTHKQLcgpkttgknvkkpvytnAKKQMLISLAPPILTLHLKRF--QQTG 718
           *****************************************999999999999999999999*********************..9999 PP
   S: 244  ksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn.........................ekg 304
           ++ +k+nk+++fp+ +dl+pfc+ ++++++e   ++ Y+L+++v HsG+++sGHY+ayvk                          +kg
   Q: 719  YNLQKVNKHIKFPEVIDLAPFCSIKCKNVAEgssRVLYSLYGIVEHSGTMRSGHYTAYVKTrattnqlsdlvlhgriqhtdaetesSKG 807
           9***********************99999888889**************************9999999999999999999999988899 PP
   S: 305  kWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +W++++D++V++v+ ++vl+   ++aY+lfY+r
   Q: 808  QWFHISDTRVQAVPVSKVLN---AQAYLLFYER 837
           9*******************...********98 PP

Organism

Anolis carolinensis

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKN VQSDDLTDIS EPVCKHLRKG LEQGHLKKVL QNVDWGSCQD CRISDNGTPE 60
KSEDEAEDKP SIWLCLKCGH RGCGRNSQEK HALKHYETPR SEPHCLVLNV DNWSVWCYLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AACGAACAAA AGGGAAAAAT GTACAGTCGG ATGACTTAAC AGACATATCA 60
GGTATGCCTT GTAAGTGCAA ACAGTATCAG TCAGTTGTAT AGCTCCTATT GGAAGTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	27.67	1.00e-24	108.00
IUUC-Aml-001931	Ailuropoda melanoleuca	59.29	0.00e+00	887.00
IUUC-Atr-003015	Amborella trichopoda	31.37	4.00e-31	130.00
IUUC-Apl-004145	Anas platyrhynchos	61.85	0.00e+00	871.00
IUUC-Bta-013362	Bos taurus	59.86	0.00e+00	888.00
IUUC-Bdi-014624	Brachypodium distachyon	29.54	7.00e-27	116.00
IUUC-Cja-019177	Callithrix jacchus	59.04	0.00e+00	906.00
IUUC-Cfa-020051	Canis familiaris	60.33	0.00e+00	903.00
IUUC-Cpo-021886	Cavia porcellus	56.40	0.00e+00	871.00
IUUC-Csa-024103	Chlorocebus sabaeus	59.39	0.00e+00	914.00
IUUC-Cho-024315	Choloepus hoffmanni	58.06	8.00e-76	278.00
IUUC-Cin-025775	Ciona intestinalis	50.70	7.00e-39	152.00
IUUC-Csv-026075	Ciona savignyi	50.25	2.00e-52	200.00
IUUC-Cme-027348	Cyanidioschyzon merolae	39.74	2.00e-20	94.00
IUUC-Dre-028388	Danio rerio	49.11	3.00e-113	402.00
IUUC-Dno-029409	Dasypus novemcinctus	59.06	0.00e+00	904.00
IUUC-Dor-030443	Dipodomys ordii	53.63	9.00e-121	427.00
IUUC-Ete-032807	Echinops telfairi	57.96	4.00e-134	471.00
IUUC-Eca-033479	Equus caballus	59.41	0.00e+00	909.00
IUUC-Eeu-034835	Erinaceus europaeus	49.10	5.00e-134	471.00
IUUC-Fca-036320	Felis catus	59.46	0.00e+00	914.00
IUUC-Fal-037029	Ficedula albicollis	62.09	0.00e+00	865.00
IUUC-Gmo-039480	Gadus morhua	48.94	9.00e-107	380.00
IUUC-Gga-040527	Gallus gallus	63.55	0.00e+00	900.00
IUUC-Gac-042343	Gasterosteus aculeatus	48.65	1.00e-112	400.00
IUUC-Gma-044402	Glycine max	29.14	2.00e-32	134.00
IUUC-Ggo-045598	Gorilla gorilla	59.62	0.00e+00	911.00
IUUC-Hsa-046598	Homo sapiens	59.51	0.00e+00	906.00
IUUC-Hvu-047146	Hordeum vulgare	36.14	6.00e-25	109.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	59.57	0.00e+00	918.00
IUUC-Lch-050536	Latimeria chalumnae	50.92	0.00e+00	715.00
IUUC-Lpe-050703	Leersia perrieri	36.94	8.00e-25	109.00
IUUC-Loc-051814	Lepisosteus oculatus	51.87	5.00e-122	431.00
IUUC-Laf-053732	Loxodonta africana	57.83	0.00e+00	886.00
IUUC-Mcc-054661	Macaca mulatta	59.62	0.00e+00	914.00
IUUC-Meu-055967	Macropus eugenii	58.37	2.00e-125	442.00
IUUC-Mtr-057945	Medicago truncatula	29.34	2.00e-31	131.00
IUUC-Mga-059551	Meleagris gallopavo	62.91	0.00e+00	895.00
IUUC-Mvi-060391	Microbotryum violaceum	32.09	3.00e-16	80.50
IUUC-Mmr-061747	Microcebus murinus	59.42	0.00e+00	889.00
IUUC-Mdo-062220	Monodelphis domestica	57.46	0.00e+00	845.00
IUUC-Mmu-063582	Mus musculus	57.97	0.00e+00	854.00
IUUC-Mac-064941	Musa acuminata	32.53	7.00e-34	139.00
IUUC-Mpu-066339	Mustela putorius furo	59.88	0.00e+00	902.00
IUUC-Mlu-067511	Myotis lucifugus	57.48	0.00e+00	870.00
IUUC-Nle-069252	Nomascus leucogenys	59.39	0.00e+00	913.00
IUUC-Opr-070969	Ochotona princeps	58.50	0.00e+00	863.00
IUUC-Ont-071786	Oreochromis niloticus	50.12	6.00e-112	398.00
IUUC-Ocu-074704	Oryctolagus cuniculus	59.37	0.00e+00	888.00
IUUC-Oba-075094	Oryza barthii	38.16	2.00e-26	114.00
IUUC-Obr-076743	Oryza brachyantha	38.82	6.00e-27	116.00
IUUC-Ogl-077739	Oryza glaberrima	30.18	3.00e-26	114.00
IUUC-Ogu-078851	Oryza glumaepatula	38.16	2.00e-26	114.00
IUUC-Oin-079402	Oryza indica	38.16	2.00e-26	114.00
IUUC-Olo-080431	Oryza longistaminata	38.16	2.00e-26	114.00
IUUC-Ome-081580	Oryza meridionalis	30.49	2.00e-26	115.00
IUUC-Oni-082644	Oryza nivara	38.16	2.00e-26	114.00
IUUC-Opu-083452	Oryza punctata	38.16	3.00e-26	114.00
IUUC-Oru-084546	Oryza rufipogon	38.16	2.00e-26	114.00
IUUC-Osa-085858	Oryza sativa	30.18	3.00e-26	114.00
IUUC-Ola-086795	Oryzias latipes	47.55	1.00e-110	394.00
IUUC-Oga-088713	Otolemur garnettii	58.99	0.00e+00	904.00
IUUC-Oar-089887	Ovis aries	59.98	0.00e+00	895.00
IUUC-Ptr-091670	Pan troglodytes	59.50	0.00e+00	907.00
IUUC-Pan-092293	Papio anubis	59.62	0.00e+00	914.00
IUUC-Psi-093101	Pelodiscus sinensis	65.29	0.00e+00	935.00
IUUC-Ppa-095622	Physcomitrella patens	30.00	2.00e-33	137.00
IUUC-Pab-098773	Pongo abelii	59.33	0.00e+00	686.00
IUUC-Pop-099136	Populus trichocarpa	29.90	6.00e-37	149.00
IUUC-Pca-101069	Procavia capensis	51.33	7.00e-165	574.00
IUUC-Ppe-101794	Prunus persica	30.45	1.00e-33	138.00
IUUC-Pva-103092	Pteropus vampyrus	51.89	2.00e-101	363.00
IUUC-Rno-105237	Rattus norvegicus	58.14	0.00e+00	856.00
IUUC-Sha-106889	Sarcophilus harrisii	59.57	0.00e+00	864.00
IUUC-Sit-110283	Setaria italica	38.00	2.00e-26	114.00
IUUC-Sly-111487	Solanum lycopersicum	30.28	2.00e-36	147.00
IUUC-Stu-112820	Solanum tuberosum	28.80	1.00e-38	155.00
IUUC-Sar-113530	Sorex araneus	57.33	0.00e+00	863.00
IUUC-Sbi-113785	Sorghum bicolor	36.67	2.00e-23	104.00
IUUC-Ssc-116091	Sus scrofa	59.58	0.00e+00	899.00
IUUC-Tgu-117478	Taeniopygia guttata	59.55	0.00e+00	835.00
IUUC-Tru-118640	Takifugu rubripes	49.11	1.00e-114	407.00
IUUC-Tsy-119042	Tarsius syrichta	49.26	9.00e-157	546.00
IUUC-Tni-120015	Tetraodon nigroviridis	44.88	3.00e-177	615.00
IUUC-Tca-121701	Theobroma cacao	30.32	1.00e-36	148.00
IUUC-Tae-125351	Triticum aestivum	29.94	3.00e-24	107.00
IUUC-Tur-126788	Triticum urartu	28.70	3.00e-24	107.00
IUUC-Tbe-127309	Tupaia belangeri	49.09	0.00e+00	652.00
IUUC-Ttr-128271	Tursiops truncatus	58.27	0.00e+00	887.00
IUUC-Vpa-130674	Vicugna pacos	58.24	0.00e+00	815.00
IUUC-Xtr-131869	Xenopus tropicalis	50.79	0.00e+00	742.00
IUUC-Xma-134195	Xiphophorus maculatus	44.27	0.00e+00	635.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence