iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045844

UUCD1 version

UUC-HoS-00387

Ensembl Protein ID

ENSP00000353735.2

UniProt Accession

Q9NS56; O43273; Q6P987; Q9NS55; Q9UNR9; TOPRS_HUMAN

Genbank Protein ID

AAD23379.1; BAB03714.1; BAB03715.1; CAH71253.1; CAH71254.1; AAH60884.1; AAC98530.1

Protein Name

E3 ubiquitin-protein ligase Topors; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; Tumor suppressor p53-binding protein 3

Genbank Nucleotide ID

AF098300; AB045732; AB045733; AL353671; AL353671; BC060884; U82939

Gene Name

TOPORS; LUN; TP53BPL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197579.7	ENST00000360538.6	ENSP00000353735.2
ENSG00000197579.7	ENST00000379858.1	ENSP00000369187.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	miRecords
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17803295; 20429939; 19473992; 15247280; 20188669

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.80e-09	37.3	103	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f++  ++ +C H f++ C+q w      s++++ CPlC+
   Q: 103  CPICLDRFDNVSYLDRCLHKFCFRCVQEW------SKNKAECPLCK 142
           **********999999*************......**********7 PP

Organism

Homo sapiens

Functional Description
(View)

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

Protein Sequence
(Fasta)

MGSQPPLGSP LSREEGEAPP PAPASEGRRR SRRVRLRGSC RHRPSFLGCR ELAASAPARP 60
APASSEIMAS AAKEFKMDNF SPKAGTSKLQ QTVPADASPD SKCPICLDRF DNVSYLDRCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAAGAAATA GGGCCTTTCC GCCTGCGGGC CCAGTGAGTC GACACGGTGG GGGCCCGCGA 60
TCCCCGGGAC TTACCACTGA ATAAATCCAG TCCAGCGTGC GACGACTTAC TGGCTTCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0682--Retinitis pigmentosa
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005814--C:centriole
GO:0036064--C:ciliary basal body
GO:0000930--C:gamma-tubulin complex
GO:0030496--C:midbody
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032391--C:photoreceptor connecting cilium
GO:0016605--C:PML body
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0003823--F:antigen binding
GO:0003677--F:DNA binding
GO:0044547--F:DNA topoisomerase binding
GO:0019789--F:SUMO transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0051457--P:maintenance of protein location in nucleus
GO:0043066--P:negative regulation of apoptotic process
GO:0035845--P:photoreceptor cell outer segment organization
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0034504--P:protein localization to nucleus
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016925--P:protein sumoylation
GO:0042127--P:regulation of cell proliferation
GO:0010842--P:retina layer formation
GO:0046549--P:retinal cone cell development
GO:0046548--P:retinal rod cell development
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:10210

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000940	Aegilops tauschii	36.76	3.00e-09	55.80
IUUC-Aml-002240	Ailuropoda melanoleuca	89.97	0.00e+00	903.00
IUUC-Atr-002964	Amborella trichopoda	33.33	4.00e-11	61.60
IUUC-Apl-003666	Anas platyrhynchos	58.11	5.00e-144	505.00
IUUC-Aca-005305	Anolis carolinensis	63.21	3.00e-148	519.00
IUUC-Aly-005926	Arabidopsis lyrata	36.56	3.00e-12	65.50
IUUC-Ath-007299	Arabidopsis thaliana	36.17	8.00e-12	64.30
IUUC-Ame-011109	Astyanax mexicanus	53.98	1.00e-114	407.00
IUUC-Bta-012637	Bos taurus	91.01	0.00e+00	918.00
IUUC-Bdi-014270	Brachypodium distachyon	40.00	2.00e-11	62.80
IUUC-Bol-015307	Brassica oleracea	34.41	2.00e-10	59.70
IUUC-Bra-017451	Brassica rapa	31.25	3.00e-08	52.40
IUUC-Cja-019105	Callithrix jacchus	96.77	0.00e+00	1015.00
IUUC-Cfa-021203	Canis familiaris	91.34	0.00e+00	914.00
IUUC-Cpo-022335	Cavia porcellus	85.34	0.00e+00	866.00
IUUC-Csa-023870	Chlorocebus sabaeus	99.15	0.00e+00	1025.00
IUUC-Cho-024870	Choloepus hoffmanni	91.77	0.00e+00	887.00
IUUC-Cne-026788	Cryptococcus neoformans	33.85	5.00e-07	50.10
IUUC-Dre-027535	Danio rerio	50.65	6.00e-121	428.00
IUUC-Dno-028963	Dasypus novemcinctus	92.19	0.00e+00	897.00
IUUC-Dor-030239	Dipodomys ordii	90.37	0.00e+00	803.00
IUUC-Dme-031941	Drosophila melanogaster	54.69	5.00e-19	90.50
IUUC-Ete-032300	Echinops telfairi	84.73	0.00e+00	1138.00
IUUC-Eca-033690	Equus caballus	93.90	0.00e+00	914.00
IUUC-Eeu-035257	Erinaceus europaeus	87.68	0.00e+00	868.00
IUUC-Fca-036383	Felis catus	90.39	0.00e+00	908.00
IUUC-Fal-037209	Ficedula albicollis	62.64	6.00e-164	571.00
IUUC-Gmo-039416	Gadus morhua	53.63	1.00e-117	416.00
IUUC-Gga-041267	Gallus gallus	71.68	7.00e-172	598.00
IUUC-Gac-042227	Gasterosteus aculeatus	51.96	2.00e-114	405.00
IUUC-Gma-042777	Glycine max	36.47	1.00e-08	53.90
IUUC-Ggo-044445	Gorilla gorilla	99.83	0.00e+00	1056.00
IUUC-Hvu-047531	Hordeum vulgare	46.00	1.00e-10	57.40
IUUC-Itr-048818	Ictidomys tridecemlineatus	92.19	0.00e+00	939.00
IUUC-Lch-050031	Latimeria chalumnae	65.69	1.00e-167	583.00
IUUC-Lpe-051274	Leersia perrieri	37.74	1.00e-08	53.50
IUUC-Loc-052944	Lepisosteus oculatus	58.40	3.00e-142	499.00
IUUC-Laf-053820	Loxodonta africana	93.66	0.00e+00	869.00
IUUC-Mcc-054800	Macaca mulatta	99.15	0.00e+00	1019.00
IUUC-Meu-056806	Macropus eugenii	72.03	0.00e+00	637.00
IUUC-Mtr-058378	Medicago truncatula	36.04	4.00e-12	65.10
IUUC-Mla-059017	Melampsora laricipopulina	36.07	4.00e-09	55.80
IUUC-Mvi-060417	Microbotryum violaceum	25.36	8.00e-17	82.80
IUUC-Mmr-061481	Microcebus murinus	94.32	0.00e+00	934.00
IUUC-Mdo-062219	Monodelphis domestica	81.45	3.00e-107	383.00
IUUC-Mmu-064138	Mus musculus	89.70	0.00e+00	837.00
IUUC-Mac-064635	Musa acuminata	38.57	8.00e-11	59.70
IUUC-Mlu-067088	Myotis lucifugus	91.69	0.00e+00	934.00
IUUC-Nle-069862	Nomascus leucogenys	99.35	0.00e+00	1070.00
IUUC-Opr-071076	Ochotona princeps	89.94	0.00e+00	803.00
IUUC-Ont-072225	Oreochromis niloticus	51.93	7.00e-110	391.00
IUUC-Oan-073069	Ornithorhynchus anatinus	66.51	5.00e-156	544.00
IUUC-Ocu-074826	Oryctolagus cuniculus	93.21	0.00e+00	941.00
IUUC-Oba-075429	Oryza barthii	37.68	2.00e-10	59.70
IUUC-Obr-076084	Oryza brachyantha	36.23	5.00e-10	58.20
IUUC-Ogl-077444	Oryza glaberrima	37.68	2.00e-10	59.70
IUUC-Ogu-078603	Oryza glumaepatula	37.68	2.00e-10	59.70
IUUC-Oin-079777	Oryza indica	37.68	2.00e-10	59.30
IUUC-Oni-082396	Oryza nivara	37.68	2.00e-10	59.70
IUUC-Opu-083698	Oryza punctata	36.62	9.00e-10	57.80
IUUC-Oru-084305	Oryza rufipogon	37.68	2.00e-10	59.70
IUUC-Ola-087377	Oryzias latipes	54.38	7.00e-107	380.00
IUUC-Oga-088059	Otolemur garnettii	90.99	0.00e+00	921.00
IUUC-Oar-089592	Ovis aries	91.41	0.00e+00	888.00
IUUC-Ptr-091233	Pan troglodytes	99.49	0.00e+00	1053.00
IUUC-Pan-092743	Papio anubis	99.15	0.00e+00	1024.00
IUUC-Psi-093669	Pelodiscus sinensis	60.36	0.00e+00	855.00
IUUC-Ppa-095668	Physcomitrella patens	25.71	2.00e-20	93.20
IUUC-Pfo-096706	Poecilia formosa	54.48	4.00e-105	375.00
IUUC-Pop-098813	Populus trichocarpa	24.49	7.00e-13	67.80
IUUC-Pca-100967	Procavia capensis	90.94	0.00e+00	821.00
IUUC-Ppe-101922	Prunus persica	35.06	1.00e-08	53.50
IUUC-Pva-102982	Pteropus vampyrus	94.07	0.00e+00	926.00
IUUC-Pgr-103551	Puccinia graminis	38.46	1.00e-08	53.90
IUUC-Ptt-103977	Puccinia triticina	33.33	7.00e-08	50.80
IUUC-Rno-105730	Rattus norvegicus	89.10	0.00e+00	793.00
IUUC-Sha-106588	Sarcophilus harrisii	68.45	7.00e-179	621.00
IUUC-Sja-107735	Schizosaccharomyces japonicus	35.38	2.00e-07	49.30
IUUC-Smo-109039	Selaginella moellendorffii	24.46	6.00e-17	82.00
IUUC-Sly-111835	Solanum lycopersicum	42.37	1.00e-08	55.50
IUUC-Stu-111938	Solanum tuberosum	31.91	8.00e-07	47.80
IUUC-Sar-113622	Sorex araneus	89.23	2.00e-162	566.00
IUUC-Sre-115041	Sporisorium reilianum	37.84	1.00e-09	57.00
IUUC-Ssc-115244	Sus scrofa	94.57	0.00e+00	885.00
IUUC-Tgu-117180	Taeniopygia guttata	65.05	1.00e-173	603.00
IUUC-Tru-118393	Takifugu rubripes	53.46	2.00e-120	426.00
IUUC-Tsy-119408	Tarsius syrichta	93.91	0.00e+00	939.00
IUUC-Tni-120664	Tetraodon nigroviridis	56.91	8.00e-121	427.00
IUUC-Tca-121712	Theobroma cacao	26.52	5.00e-16	78.20
IUUC-Tae-122787	Triticum aestivum	38.57	1.00e-10	60.50
IUUC-Tbe-127301	Tupaia belangeri	85.25	0.00e+00	840.00
IUUC-Ttr-128204	Tursiops truncatus	92.48	0.00e+00	952.00
IUUC-Uma-129420	Ustilago maydis	43.06	1.00e-09	57.40
IUUC-Vpa-130297	Vicugna pacos	93.97	0.00e+00	912.00
IUUC-Vvi-131157	Vitis vinifera	25.84	6.00e-17	81.60
IUUC-Xtr-132845	Xenopus tropicalis	67.13	4.00e-169	588.00
IUUC-Xma-133439	Xiphophorus maculatus	53.26	1.00e-107	384.00
IUUC-Yli-134652	Yarrowia lipolytica	38.78	5.00e-06	46.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence