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Tag Content
iUUCD ID IUUC-Bta-013124
UUCD1 version UUC-BoT-00913
Ensembl Protein ID ENSBTAP00000005011.5
UniProt Accession O18973; RABX5_BOVIN
Genbank Protein ID CAA04545.1
Protein Name Rab5 GDP/GTP exchange factor; Rabex-5
Genbank Nucleotide ID AJ001119
Gene Name RABGEF1; RABEX5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000003842.5 ENSBTAT00000005011.5 ENSBTAP00000005011.5
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/ZnF_A20 ZnF_A20 16407276; 16462746
UBD/Alpha-Helix/MIU MIU 16407276; 16462746
Classification
Family E-value Score Start End
UBD/Alpha-Helix/MIU 3.10e-08 33.5 47 70
UBD/ZnF/ZnF_A20 1.00e-18 67.1 13 47
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/MIU
   S: 1    rqkQprtDlELAqqLQqEeyqqfa 24
           rqkQ+++D+ELA++LQ+Ee+++fa
   Q: 47   RQKQIQEDWELAERLQREEEEAFA 70
           8********************986 PP
   

   UBD/ZnF/ZnF_A20
   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           d+s+llCkkgCg+YGnp+++g+CSkC+ree++++r
   Q: 13   DQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKAR 47
           79*******************************86 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
 Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
Protein Sequence
(Fasta)
MSLKSERRGI HVDQSELLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER 60
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGAKKEIQEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013124|UBD,ZnF_A20;UBD,MIU|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCAGGAGGA AGATGAGCCT TAAGTCTGAA CGCCGAGGAA TTCATGTGGA TCAGTCGGAG 60
CTCCTATGCA AGAAAGGATG TGGTTACTAC GGCAACCCTG CTTGGCAGGG TTTCTGCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013124|UBD,ZnF_A20;UBD,MIU|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003123--VPS9
IPR002653--Znf_A20
PROSITE

PS51205--VPS9
PS51036--ZF_A20
Pfam

PF02204--VPS9
PF01754--zf-A20
SMART

SM00167--VPS9
SM00259--ZnF_A20
Gene Ontology

GO:0005769--C:early endosome
GO:0055037--C:recycling endosome
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0015031--P:protein transport
KEGG bta:282335
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000198 Aegilops tauschii 31.96 2.00e-20 94.00
IUUC-Aml-001771 Ailuropoda melanoleuca 88.21 0.00e+00 754.00
IUUC-Atr-003154 Amborella trichopoda 36.52 2.00e-22 100.00
IUUC-Apl-004018 Anas platyrhynchos 92.07 0.00e+00 848.00
IUUC-Aca-005227 Anolis carolinensis 23.47 3.00e-09 57.40
IUUC-Aly-006138 Arabidopsis lyrata 35.45 1.00e-24 107.00
IUUC-Ath-006747 Arabidopsis thaliana 34.92 2.00e-24 107.00
IUUC-Ago-007776 Ashbya gossypii 30.00 7.00e-24 104.00
IUUC-Acl-008235 Aspergillus clavatus 31.12 1.00e-28 122.00
IUUC-Afl-008570 Aspergillus flavus 32.12 2.00e-31 130.00
IUUC-Afu-008815 Aspergillus fumigatus 29.66 2.00e-29 124.00
IUUC-Ani-009381 Aspergillus nidulans 30.39 1.00e-29 124.00
IUUC-Ang-009615 Aspergillus niger 30.82 1.00e-31 130.00
IUUC-Aor-010195 Aspergillus oryzae 31.79 5.00e-32 132.00
IUUC-Ate-010514 Aspergillus terreus 31.82 3.00e-30 126.00
IUUC-Ame-011365 Astyanax mexicanus 66.34 0.00e+00 672.00
IUUC-Bgr-012102 Blumeria graminis 28.75 1.00e-29 125.00
IUUC-Bci-013943 Botrytis cinerea 30.50 9.00e-30 125.00
IUUC-Bdi-014539 Brachypodium distachyon 33.94 5.00e-26 112.00
IUUC-Bol-016580 Brassica oleracea 35.14 5.00e-30 125.00
IUUC-Bra-017843 Brassica rapa 34.68 8.00e-30 124.00
IUUC-Cel-018199 Caenorhabditis elegans 34.10 1.00e-59 223.00
IUUC-Cja-019941 Callithrix jacchus 97.35 0.00e+00 885.00
IUUC-Cfa-020845 Canis familiaris 98.04 0.00e+00 818.00
IUUC-Cpo-022037 Cavia porcellus 96.33 0.00e+00 875.00
IUUC-Cre-022696 Chlamydomonas reinhardtii 32.49 2.00e-21 97.40
IUUC-Csa-023272 Chlorocebus sabaeus 96.54 0.00e+00 880.00
IUUC-Cho-025076 Choloepus hoffmanni 85.74 0.00e+00 743.00
IUUC-Cin-025400 Ciona intestinalis 45.22 2.00e-116 412.00
IUUC-Csv-025941 Ciona savignyi 37.63 8.00e-86 311.00
IUUC-Cgl-026725 Colletotrichum gloeosporioides 29.08 4.00e-27 116.00
IUUC-Cne-027057 Cryptococcus neoformans 31.42 3.00e-34 140.00
IUUC-Dre-028484 Danio rerio 71.29 0.00e+00 677.00
IUUC-Dno-028906 Dasypus novemcinctus 97.76 0.00e+00 875.00
IUUC-Dor-030124 Dipodomys ordii 86.33 0.00e+00 753.00
IUUC-Dse-031437 Dothistroma septosporum 28.32 8.00e-26 112.00
IUUC-Dme-031696 Drosophila melanogaster 32.36 9.00e-68 251.00
IUUC-Ete-032573 Echinops telfairi 92.00 0.00e+00 717.00
IUUC-Eca-033711 Equus caballus 98.78 0.00e+00 900.00
IUUC-Eeu-034459 Erinaceus europaeus 73.79 2.00e-79 290.00
IUUC-Fca-035447 Felis catus 95.72 0.00e+00 905.00
IUUC-Fal-036605 Ficedula albicollis 88.71 0.00e+00 787.00
IUUC-Fox-037967 Fusarium oxysporum 26.71 3.00e-18 87.00
IUUC-Fso-038110 Fusarium solani 29.68 8.00e-29 122.00
IUUC-Gmo-038785 Gadus morhua 67.19 0.00e+00 681.00
IUUC-Ggr-039760 Gaeumannomyces graminis 30.69 3.00e-27 117.00
IUUC-Gga-040584 Gallus gallus 92.68 0.00e+00 852.00
IUUC-Gac-042469 Gasterosteus aculeatus 64.19 1.00e-167 582.00
IUUC-Gma-044237 Glycine max 37.43 5.00e-26 112.00
IUUC-Ggo-044498 Gorilla gorilla 83.33 0.00e+00 731.00
IUUC-Hsa-046625 Homo sapiens 97.35 0.00e+00 886.00
IUUC-Hvu-047155 Hordeum vulgare 37.78 2.00e-26 113.00
IUUC-Itr-048753 Ictidomys tridecemlineatus 96.74 0.00e+00 880.00
IUUC-Kpa-049160 Komagataella pastoris 29.05 2.00e-24 107.00
IUUC-Lch-050529 Latimeria chalumnae 78.88 0.00e+00 855.00
IUUC-Lpe-051024 Leersia perrieri 34.39 2.00e-28 120.00
IUUC-Loc-052644 Lepisosteus oculatus 70.20 0.00e+00 669.00
IUUC-Lma-053102 Leptosphaeria maculans 30.65 2.00e-27 117.00
IUUC-Laf-054337 Loxodonta africana 95.11 0.00e+00 870.00
IUUC-Mcc-055659 Macaca mulatta 96.97 3.00e-179 620.00
IUUC-Meu-056084 Macropus eugenii 75.57 2.00e-93 336.00
IUUC-Mor-057255 Magnaporthe oryzae 29.60 1.00e-26 115.00
IUUC-Mpo-057454 Magnaporthe poae 30.69 5.00e-29 122.00
IUUC-Mtr-058098 Medicago truncatula 34.55 3.00e-30 126.00
IUUC-Mla-059068 Melampsora laricipopulina 29.79 3.00e-31 129.00
IUUC-Mga-059624 Meleagris gallopavo 79.03 0.00e+00 843.00
IUUC-Mvi-060282 Microbotryum violaceum 28.62 4.00e-26 113.00
IUUC-Mmr-061142 Microcebus murinus 97.96 0.00e+00 897.00
IUUC-Mdo-062289 Monodelphis domestica 93.08 0.00e+00 902.00
IUUC-Mmu-063961 Mus musculus 96.33 0.00e+00 877.00
IUUC-Mac-065188 Musa acuminata 33.07 7.00e-23 101.00
IUUC-Mpu-066291 Mustela putorius furo 96.95 0.00e+00 881.00
IUUC-Mlu-067431 Myotis lucifugus 93.50 0.00e+00 848.00
IUUC-Nfi-068422 Neosartorya fischeri 30.79 5.00e-30 126.00
IUUC-Ncr-068843 Neurospora crassa 29.89 2.00e-28 121.00
IUUC-Nle-069079 Nomascus leucogenys 96.74 0.00e+00 880.00
IUUC-Opr-070790 Ochotona princeps 92.59 3.00e-56 213.00
IUUC-Ont-071789 Oreochromis niloticus 67.65 4.00e-179 620.00
IUUC-Oan-072946 Ornithorhynchus anatinus 90.26 0.00e+00 816.00
IUUC-Ocu-073816 Oryctolagus cuniculus 97.97 0.00e+00 886.00
IUUC-Oba-075738 Oryza barthii 33.15 3.00e-17 82.80
IUUC-Obr-076355 Oryza brachyantha 37.91 3.00e-27 116.00
IUUC-Ogl-077592 Oryza glaberrima 28.35 8.00e-27 114.00
IUUC-Ogu-078197 Oryza glumaepatula 28.35 1.00e-26 114.00
IUUC-Oin-080047 Oryza indica 37.22 2.00e-25 110.00
IUUC-Olo-080317 Oryza longistaminata 28.35 1.00e-26 113.00
IUUC-Ome-081589 Oryza meridionalis 37.22 6.00e-26 112.00
IUUC-Oni-082700 Oryza nivara 33.15 3.00e-17 83.20
IUUC-Opu-083923 Oryza punctata 34.36 2.00e-21 95.90
IUUC-Oru-084318 Oryza rufipogon 33.15 3.00e-17 83.20
IUUC-Osa-086246 Oryza sativa 38.98 1.00e-06 43.90
IUUC-Ola-086730 Oryzias latipes 56.79 1.00e-150 526.00
IUUC-Olu-087719 Ostreococcus lucimarinus 34.46 2.00e-23 103.00
IUUC-Oga-088992 Otolemur garnettii 84.86 0.00e+00 885.00
IUUC-Oar-089789 Ovis aries 99.39 0.00e+00 896.00
IUUC-Ptr-091636 Pan troglodytes 97.35 0.00e+00 885.00
IUUC-Pan-092911 Papio anubis 96.74 0.00e+00 880.00
IUUC-Psi-093194 Pelodiscus sinensis 79.65 0.00e+00 842.00
IUUC-Pma-094212 Petromyzon marinus 48.49 3.00e-115 408.00
IUUC-Pno-094831 Phaeosphaeria nodorum 29.89 3.00e-27 117.00
IUUC-Ppa-095705 Physcomitrella patens 34.39 1.00e-28 121.00
IUUC-Pfo-096694 Poecilia formosa 65.42 1.00e-180 625.00
IUUC-Pab-097706 Pongo abelii 97.15 0.00e+00 884.00
IUUC-Pop-099891 Populus trichocarpa 32.84 8.00e-26 111.00
IUUC-Pca-100879 Procavia capensis 94.37 8.00e-93 333.00
IUUC-Ppe-101334 Prunus persica 33.78 2.00e-26 113.00
IUUC-Pva-103225 Pteropus vampyrus 82.63 0.00e+00 721.00
IUUC-Pgr-103564 Puccinia graminis 30.38 4.00e-31 129.00
IUUC-Ptt-103802 Puccinia triticina 30.23 4.00e-26 112.00
IUUC-Pte-104345 Pyrenophora teres 29.52 2.00e-27 118.00
IUUC-Pyt-104716 Pyrenophora triticirepentis 30.60 2.00e-28 120.00
IUUC-Rno-106101 Rattus norvegicus 95.93 0.00e+00 876.00
IUUC-Sce-106460 Saccharomyces cerevisiae 30.38 1.00e-24 107.00
IUUC-Sha-106919 Sarcophilus harrisii 78.62 0.00e+00 842.00
IUUC-Sja-107880 Schizosaccharomyces japonicus 32.17 7.00e-30 125.00
IUUC-Spo-108087 Schizosaccharomyces pombe 29.84 2.00e-27 117.00
IUUC-Ssl-108614 Sclerotinia sclerotiorum 29.82 2.00e-07 51.60
IUUC-Smo-109411 Selaginella moellendorffii 37.14 2.00e-28 120.00
IUUC-Sit-110678 Setaria italica 37.22 3.00e-26 112.00
IUUC-Sly-111526 Solanum lycopersicum 37.85 2.00e-25 110.00
IUUC-Stu-112494 Solanum tuberosum 38.42 5.00e-26 112.00
IUUC-Sar-112929 Sorex araneus 98.91 1.00e-164 573.00
IUUC-Sbi-114242 Sorghum bicolor 32.94 4.00e-28 119.00
IUUC-Sre-115224 Sporisorium reilianum 31.79 4.00e-30 127.00
IUUC-Ssc-115239 Sus scrofa 98.37 0.00e+00 894.00
IUUC-Tgu-117499 Taeniopygia guttata 90.43 0.00e+00 831.00
IUUC-Tru-118027 Takifugu rubripes 64.14 6.00e-144 504.00
IUUC-Tsy-119462 Tarsius syrichta 97.69 0.00e+00 867.00
IUUC-Tni-120855 Tetraodon nigroviridis 64.54 1.00e-174 605.00
IUUC-Tca-121213 Theobroma cacao 33.03 5.00e-25 108.00
IUUC-Tre-122186 Trichoderma reesei 29.32 2.00e-28 120.00
IUUC-Tvi-122541 Trichoderma virens 27.97 7.00e-29 122.00
IUUC-Tae-123631 Triticum aestivum 34.24 3.00e-27 116.00
IUUC-Tur-126572 Triticum urartu 31.77 1.00e-26 114.00
IUUC-Tme-127023 Tuber melanosporum 32.93 1.00e-31 131.00
IUUC-Tbe-127453 Tupaia belangeri 97.66 0.00e+00 782.00
IUUC-Ttr-128526 Tursiops truncatus 98.78 0.00e+00 897.00
IUUC-Uma-129660 Ustilago maydis 32.56 2.00e-30 127.00
IUUC-Vda-129737 Verticillium dahliae 28.33 4.00e-24 106.00
IUUC-Vpa-130505 Vicugna pacos 91.95 0.00e+00 722.00
IUUC-Vvi-131088 Vitis vinifera 37.08 1.00e-23 104.00
IUUC-Xtr-132799 Xenopus tropicalis 80.49 0.00e+00 746.00
IUUC-Xma-133345 Xiphophorus maculatus 65.82 3.00e-176 611.00
IUUC-Yli-134416 Yarrowia lipolytica 30.97 4.00e-32 132.00
IUUC-Zma-134750 Zea mays 37.22 6.00e-26 112.00
Created Date 25-Jun-2017

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