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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063961
UUCD1 version UUC-MuM-00995
Ensembl Protein ID ENSMUSP00000114103.1
UniProt Accession Q9JM13; Q3UIW0; RABX5_MOUSE
Genbank Protein ID AAF28738.1; BAC31984.1; BAE27396.1; AAH18229.1
Protein Name Rab5 GDP/GTP exchange factor; Rabex-5
Genbank Nucleotide ID AF093590; AK044568; AK146734; BC018229
Gene Name Rabgef1; Rabex5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025340.14 ENSMUST00000119797.7 ENSMUSP00000114103.1
ENSMUSG00000025340.14 ENSMUST00000148264.7 ENSMUSP00000119245.1
ENSMUSG00000025340.14 ENSMUST00000143865.1 ENSMUSP00000118590.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/ZnF_A20 2.00e-18 67.1 13 47
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/ZnF_A20
   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           d+s+llCkkgCg+YGnp+++g+CSkC+ree++++r
   Q: 13   DQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKAR 47
           79*******************************86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A (By similarity). Can act as a ubiquitin ligase (By similarity).
 Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A (By similarity). Can act as a ubiquitin ligase (By similarity).
Protein Sequence
(Fasta)
MSLKSERRGI HVDQSELLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQRQ IQEDWELAER 60
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR AGSKKEIQEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063961|UBD,ZnF_A20|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGGCGGGG CGTGCGGGGG CAGGGGCGGG GCAGGGAGCC GAGTGACTGA AGGGGCGCTG 60
GGAGCGGCGG TCGGACGCCG GCGGAGCCGC GGAGCAGGTT CGGAGGGACG GGGGCTCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063961|UBD,ZnF_A20|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003123--VPS9
IPR002653--Znf_A20
PROSITE

PS51205--VPS9
PS51036--ZF_A20
Pfam

PF02204--VPS9
PF01754--zf-A20
SMART

SM00167--VPS9
SM00259--ZnF_A20
Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005730--C:nucleolus
GO:0055037--C:recycling endosome
GO:0031982--C:vesicle
GO:0003677--F:DNA binding
GO:0017137--F:Rab GTPase binding
GO:0017112--F:Rab guanyl-nucleotide exchange factor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0050728--P:negative regulation of inflammatory response
GO:1900165--P:negative regulation of interleukin-6 secretion
GO:1900235--P:negative regulation of Kit signaling pathway
GO:0002686--P:negative regulation of leukocyte migration
GO:0033004--P:negative regulation of mast cell activation
GO:0043305--P:negative regulation of mast cell degranulation
GO:0001933--P:negative regulation of protein phosphorylation
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0048261--P:negative regulation of receptor-mediated endocytosis
GO:0006612--P:protein targeting to membrane
GO:0060368--P:regulation of Fc receptor mediated stimulatory signaling pathway
KEGG mmu:56715
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000198 Aegilops tauschii 31.51 1.00e-19 91.70
IUUC-Aml-001771 Ailuropoda melanoleuca 86.08 0.00e+00 735.00
IUUC-Atr-003154 Amborella trichopoda 35.39 1.00e-21 97.80
IUUC-Apl-004018 Anas platyrhynchos 90.85 0.00e+00 840.00
IUUC-Aca-005227 Anolis carolinensis 23.98 2.00e-09 58.20
IUUC-Aly-006138 Arabidopsis lyrata 34.92 6.00e-24 105.00
IUUC-Ath-006929 Arabidopsis thaliana 32.14 2.00e-25 110.00
IUUC-Ago-007776 Ashbya gossypii 30.00 5.00e-24 105.00
IUUC-Acl-008235 Aspergillus clavatus 31.12 3.00e-28 120.00
IUUC-Afl-008570 Aspergillus flavus 32.45 2.00e-31 130.00
IUUC-Afu-008815 Aspergillus fumigatus 30.03 3.00e-29 123.00
IUUC-Ani-009381 Aspergillus nidulans 30.39 5.00e-29 123.00
IUUC-Ang-009615 Aspergillus niger 29.28 4.00e-31 129.00
IUUC-Aor-010195 Aspergillus oryzae 32.45 5.00e-32 132.00
IUUC-Ate-010514 Aspergillus terreus 31.88 5.00e-30 126.00
IUUC-Ame-011365 Astyanax mexicanus 66.34 0.00e+00 669.00
IUUC-Bgr-012102 Blumeria graminis 28.57 1.00e-29 125.00
IUUC-Bta-013124 Bos taurus 96.33 0.00e+00 877.00
IUUC-Bci-013943 Botrytis cinerea 30.50 1.00e-29 125.00
IUUC-Bdi-014539 Brachypodium distachyon 33.94 3.00e-25 109.00
IUUC-Bol-016580 Brassica oleracea 34.68 3.00e-29 123.00
IUUC-Bra-017843 Brassica rapa 34.23 5.00e-29 122.00
IUUC-Cel-018199 Caenorhabditis elegans 33.85 1.00e-59 224.00
IUUC-Cja-019941 Callithrix jacchus 96.13 0.00e+00 876.00
IUUC-Cfa-020845 Canis familiaris 96.30 0.00e+00 801.00
IUUC-Cpo-022037 Cavia porcellus 96.13 0.00e+00 870.00
IUUC-Cre-022696 Chlamydomonas reinhardtii 31.82 8.00e-21 95.10
IUUC-Csa-023272 Chlorocebus sabaeus 95.11 0.00e+00 867.00
IUUC-Cho-025076 Choloepus hoffmanni 84.32 0.00e+00 729.00
IUUC-Cin-025400 Ciona intestinalis 45.11 3.00e-116 412.00
IUUC-Csv-025941 Ciona savignyi 38.18 5.00e-87 315.00
IUUC-Cgl-026725 Colletotrichum gloeosporioides 29.43 7.00e-27 115.00
IUUC-Cne-027057 Cryptococcus neoformans 32.09 1.00e-34 141.00
IUUC-Dre-028484 Danio rerio 71.09 0.00e+00 674.00
IUUC-Dno-028906 Dasypus novemcinctus 95.73 0.00e+00 861.00
IUUC-Dor-030124 Dipodomys ordii 85.92 0.00e+00 749.00
IUUC-Dse-031437 Dothistroma septosporum 28.67 2.00e-25 111.00
IUUC-Dme-031696 Drosophila melanogaster 32.71 8.00e-69 254.00
IUUC-Ete-032573 Echinops telfairi 91.47 0.00e+00 711.00
IUUC-Eca-033711 Equus caballus 96.74 0.00e+00 881.00
IUUC-Eeu-034459 Erinaceus europaeus 70.39 1.00e-75 277.00
IUUC-Fca-035447 Felis catus 93.69 0.00e+00 885.00
IUUC-Fal-036605 Ficedula albicollis 87.47 0.00e+00 776.00
IUUC-Fox-037967 Fusarium oxysporum 26.62 2.00e-18 87.40
IUUC-Fso-038110 Fusarium solani 30.04 9.00e-29 122.00
IUUC-Gmo-038785 Gadus morhua 66.40 0.00e+00 675.00
IUUC-Ggr-039760 Gaeumannomyces graminis 31.05 3.00e-27 117.00
IUUC-Gga-040584 Gallus gallus 91.26 0.00e+00 839.00
IUUC-Gac-042469 Gasterosteus aculeatus 64.19 2.00e-168 585.00
IUUC-Gma-044237 Glycine max 36.87 4.00e-25 109.00
IUUC-Ggo-044498 Gorilla gorilla 82.72 0.00e+00 727.00
IUUC-Hsa-046625 Homo sapiens 95.72 0.00e+00 873.00
IUUC-Hvu-047155 Hordeum vulgare 37.22 2.00e-25 110.00
IUUC-Itr-048753 Ictidomys tridecemlineatus 95.72 0.00e+00 868.00
IUUC-Kpa-049160 Komagataella pastoris 29.39 7.00e-24 105.00
IUUC-Lch-050529 Latimeria chalumnae 77.76 0.00e+00 842.00
IUUC-Lpe-051024 Leersia perrieri 34.39 1.00e-27 117.00
IUUC-Loc-052644 Lepisosteus oculatus 70.02 0.00e+00 667.00
IUUC-Lma-053102 Leptosphaeria maculans 30.70 3.00e-27 117.00
IUUC-Laf-054337 Loxodonta africana 94.09 0.00e+00 861.00
IUUC-Mcc-055659 Macaca mulatta 94.49 2.00e-174 605.00
IUUC-Meu-056084 Macropus eugenii 76.02 4.00e-94 338.00
IUUC-Mor-057255 Magnaporthe oryzae 29.96 1.00e-26 114.00
IUUC-Mpo-057454 Magnaporthe poae 31.05 6.00e-29 122.00
IUUC-Mtr-058098 Medicago truncatula 34.09 2.00e-29 123.00
IUUC-Mla-059068 Melampsora laricipopulina 30.30 1.00e-30 127.00
IUUC-Mga-059624 Meleagris gallopavo 77.82 0.00e+00 830.00
IUUC-Mvi-060282 Microbotryum violaceum 28.22 4.00e-25 110.00
IUUC-Mmr-061142 Microcebus murinus 96.74 0.00e+00 887.00
IUUC-Mdo-062289 Monodelphis domestica 92.87 0.00e+00 898.00
IUUC-Mac-065188 Musa acuminata 33.33 4.00e-22 99.40
IUUC-Mpu-066291 Mustela putorius furo 95.73 0.00e+00 870.00
IUUC-Mlu-067431 Myotis lucifugus 91.46 0.00e+00 828.00
IUUC-Nfi-068422 Neosartorya fischeri 31.44 4.00e-30 126.00
IUUC-Ncr-068843 Neurospora crassa 28.34 1.00e-28 121.00
IUUC-Nle-069079 Nomascus leucogenys 95.32 0.00e+00 867.00
IUUC-Opr-070790 Ochotona princeps 94.44 1.00e-56 214.00
IUUC-Ont-071789 Oreochromis niloticus 68.13 9.00e-178 616.00
IUUC-Oan-072946 Ornithorhynchus anatinus 89.05 0.00e+00 806.00
IUUC-Ocu-073816 Oryctolagus cuniculus 96.54 0.00e+00 873.00
IUUC-Oba-075738 Oryza barthii 32.58 2.00e-16 80.50
IUUC-Obr-076355 Oryza brachyantha 37.36 2.00e-26 113.00
IUUC-Ogl-077592 Oryza glaberrima 28.35 1.00e-26 113.00
IUUC-Ogu-078197 Oryza glumaepatula 28.35 1.00e-26 114.00
IUUC-Oin-080047 Oryza indica 37.08 1.00e-24 107.00
IUUC-Olo-080317 Oryza longistaminata 28.35 2.00e-26 113.00
IUUC-Ome-081589 Oryza meridionalis 36.67 4.00e-25 109.00
IUUC-Oni-082700 Oryza nivara 32.58 2.00e-16 80.50
IUUC-Opu-083923 Oryza punctata 34.36 3.00e-21 95.50
IUUC-Oru-084318 Oryza rufipogon 32.58 2.00e-16 80.50
IUUC-Osa-086246 Oryza sativa 38.98 1.00e-06 43.90
IUUC-Ola-086730 Oryzias latipes 57.45 1.00e-151 530.00
IUUC-Olu-087719 Ostreococcus lucimarinus 33.90 8.00e-23 101.00
IUUC-Oga-088992 Otolemur garnettii 83.80 0.00e+00 874.00
IUUC-Oar-089789 Ovis aries 96.15 0.00e+00 870.00
IUUC-Ptr-091636 Pan troglodytes 95.72 0.00e+00 872.00
IUUC-Pan-092911 Papio anubis 95.32 0.00e+00 868.00
IUUC-Psi-093194 Pelodiscus sinensis 78.26 0.00e+00 825.00
IUUC-Pma-094212 Petromyzon marinus 49.09 5.00e-115 407.00
IUUC-Pno-094831 Phaeosphaeria nodorum 30.25 4.00e-27 116.00
IUUC-Ppa-095705 Physcomitrella patens 31.01 2.00e-28 120.00
IUUC-Pfo-096694 Poecilia formosa 64.23 6.00e-178 617.00
IUUC-Pab-097706 Pongo abelii 95.52 0.00e+00 870.00
IUUC-Pop-099891 Populus trichocarpa 32.21 4.00e-25 109.00
IUUC-Pca-100879 Procavia capensis 92.49 7.00e-90 323.00
IUUC-Ppe-101334 Prunus persica 31.76 1.00e-25 110.00
IUUC-Pva-103225 Pteropus vampyrus 81.01 0.00e+00 704.00
IUUC-Pgr-103564 Puccinia graminis 30.38 6.00e-31 129.00
IUUC-Ptt-103802 Puccinia triticina 45.61 1.00e-24 107.00
IUUC-Pte-104345 Pyrenophora teres 29.50 2.00e-27 117.00
IUUC-Pyt-104716 Pyrenophora triticirepentis 29.79 2.00e-28 120.00
IUUC-Rno-106101 Rattus norvegicus 99.19 0.00e+00 900.00
IUUC-Sce-106460 Saccharomyces cerevisiae 30.04 6.00e-25 108.00
IUUC-Sha-106919 Sarcophilus harrisii 78.27 0.00e+00 838.00
IUUC-Sja-107880 Schizosaccharomyces japonicus 31.63 9.00e-30 125.00
IUUC-Spo-108087 Schizosaccharomyces pombe 30.23 2.00e-27 117.00
IUUC-Ssl-108614 Sclerotinia sclerotiorum 29.82 2.00e-07 51.60
IUUC-Smo-109411 Selaginella moellendorffii 36.57 1.00e-27 117.00
IUUC-Sit-110678 Setaria italica 34.65 2.00e-25 110.00
IUUC-Sly-111526 Solanum lycopersicum 37.29 1.00e-24 107.00
IUUC-Stu-112494 Solanum tuberosum 37.85 4.00e-25 109.00
IUUC-Sar-112929 Sorex araneus 97.45 6.00e-162 564.00
IUUC-Sbi-114242 Sorghum bicolor 33.20 1.00e-27 117.00
IUUC-Sre-115224 Sporisorium reilianum 30.96 2.00e-29 124.00
IUUC-Ssc-115239 Sus scrofa 96.34 0.00e+00 873.00
IUUC-Tgu-117499 Taeniopygia guttata 89.21 0.00e+00 822.00
IUUC-Tru-118450 Takifugu rubripes 59.40 3.00e-169 588.00
IUUC-Tsy-119462 Tarsius syrichta 95.59 0.00e+00 850.00
IUUC-Tni-120855 Tetraodon nigroviridis 63.35 7.00e-173 600.00
IUUC-Tca-121213 Theobroma cacao 32.57 4.00e-24 105.00
IUUC-Tre-122186 Trichoderma reesei 29.32 4.00e-28 119.00
IUUC-Tvi-122541 Trichoderma virens 28.53 4.00e-29 123.00
IUUC-Tae-123631 Triticum aestivum 34.51 2.00e-26 114.00
IUUC-Tur-126572 Triticum urartu 38.33 1.00e-25 110.00
IUUC-Tme-127023 Tuber melanosporum 33.33 2.00e-31 131.00
IUUC-Tbe-127453 Tupaia belangeri 96.10 0.00e+00 770.00
IUUC-Ttr-128526 Tursiops truncatus 95.93 0.00e+00 873.00
IUUC-Uma-129660 Ustilago maydis 31.91 1.00e-29 125.00
IUUC-Vda-129737 Verticillium dahliae 29.08 1.00e-23 105.00
IUUC-Vpa-130505 Vicugna pacos 89.09 0.00e+00 701.00
IUUC-Vvi-131088 Vitis vinifera 36.52 7.00e-23 101.00
IUUC-Xtr-132799 Xenopus tropicalis 80.69 0.00e+00 741.00
IUUC-Xma-133345 Xiphophorus maculatus 64.83 7.00e-174 603.00
IUUC-Yli-134416 Yarrowia lipolytica 31.39 7.00e-31 128.00
IUUC-Zma-134750 Zea mays 36.67 5.00e-25 108.00
Created Date 25-Jun-2017

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