iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044470

Ensembl Protein ID

ENSGGOP00000007407.2

UniProt Accession

G3QX74; G3QX74_GORGO

Protein Name

Uncharacterized protein

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000007561.2	ENSGGOT00000007603.2	ENSGGOP00000007407.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-15	56.6	91	145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 91   VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--TLNGRTGWFPSNYVREVK 145
           78999*********************7..999*******..8**************996 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

CLFNFSFQTF DANDLYQGQN FNKVLSSLVT LNKVTADIGL GSDSVCARPS SHRIKSFDSL 60
GSQSLHTRTS KLFQGQYRSL DMTDNSNNQL VVRAKFNFQQ TNEDELSFSK GDVIHVTRVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCTTGTTTA ATTTTTCCTT TCAGACGTTT GATGCAAATG ATTTGTATCA GGGGCAGAAT 60
TTTAACAAGG TCCTCAGTTC CTTAGTGACT CTAAATAAAG TAACAGCAGG TAAGACTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	94.02	0.00e+00	1194.00
IUUC-Aca-004591	Anolis carolinensis	86.69	0.00e+00	1169.00
IUUC-Ame-010759	Astyanax mexicanus	73.45	0.00e+00	1098.00
IUUC-Bta-013328	Bos taurus	89.23	0.00e+00	1298.00
IUUC-Bci-013864	Botrytis cinerea	44.07	8.00e-12	66.20
IUUC-Cja-018742	Callithrix jacchus	98.15	0.00e+00	1254.00
IUUC-Cfa-020756	Canis familiaris	83.18	0.00e+00	1214.00
IUUC-Cpo-021284	Cavia porcellus	88.47	0.00e+00	1238.00
IUUC-Csa-023162	Chlorocebus sabaeus	93.79	0.00e+00	1351.00
IUUC-Cho-024736	Choloepus hoffmanni	73.62	4.00e-173	601.00
IUUC-Cin-025535	Ciona intestinalis	40.31	4.00e-94	338.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	41.43	2.00e-11	65.50
IUUC-Cne-026866	Cryptococcus neoformans	50.79	2.00e-13	72.40
IUUC-Dre-028646	Danio rerio	72.94	0.00e+00	1088.00
IUUC-Dno-029461	Dasypus novemcinctus	90.24	0.00e+00	1293.00
IUUC-Dor-030623	Dipodomys ordii	83.31	0.00e+00	1004.00
IUUC-Dme-032219	Drosophila melanogaster	46.51	7.00e-103	369.00
IUUC-Ete-032236	Echinops telfairi	80.24	0.00e+00	804.00
IUUC-Eca-034137	Equus caballus	91.30	0.00e+00	1286.00
IUUC-Fca-035742	Felis catus	83.89	0.00e+00	1189.00
IUUC-Fal-037205	Ficedula albicollis	88.84	0.00e+00	1120.00
IUUC-Fox-037757	Fusarium oxysporum	38.89	2.00e-11	65.50
IUUC-Fso-038433	Fusarium solani	38.89	1.00e-11	65.90
IUUC-Gmo-039475	Gadus morhua	65.69	0.00e+00	888.00
IUUC-Gga-040539	Gallus gallus	80.79	0.00e+00	1043.00
IUUC-Gac-042615	Gasterosteus aculeatus	62.82	0.00e+00	826.00
IUUC-Hsa-046398	Homo sapiens	98.43	0.00e+00	1248.00
IUUC-Loc-052146	Lepisosteus oculatus	81.19	0.00e+00	1176.00
IUUC-Laf-053891	Loxodonta africana	89.23	0.00e+00	1327.00
IUUC-Mcc-055483	Macaca mulatta	98.14	0.00e+00	1246.00
IUUC-Mga-059410	Meleagris gallopavo	88.59	0.00e+00	1266.00
IUUC-Mmr-060758	Microcebus murinus	94.74	0.00e+00	1156.00
IUUC-Mdo-061900	Monodelphis domestica	81.37	0.00e+00	1193.00
IUUC-Mmu-063849	Mus musculus	92.18	0.00e+00	1135.00
IUUC-Mpu-065876	Mustela putorius furo	82.74	0.00e+00	1199.00
IUUC-Mlu-067970	Myotis lucifugus	90.92	0.00e+00	1283.00
IUUC-Nle-069685	Nomascus leucogenys	83.05	0.00e+00	1143.00
IUUC-Opr-071132	Ochotona princeps	63.60	0.00e+00	709.00
IUUC-Ont-071815	Oreochromis niloticus	73.57	0.00e+00	1087.00
IUUC-Oan-073057	Ornithorhynchus anatinus	87.57	0.00e+00	1128.00
IUUC-Ola-086663	Oryzias latipes	72.34	0.00e+00	1016.00
IUUC-Oga-088103	Otolemur garnettii	90.71	0.00e+00	1251.00
IUUC-Ptr-091162	Pan troglodytes	98.72	0.00e+00	1264.00
IUUC-Pan-092093	Papio anubis	82.83	0.00e+00	1195.00
IUUC-Pma-094261	Petromyzon marinus	66.25	3.00e-125	441.00
IUUC-Pfo-096736	Poecilia formosa	66.33	0.00e+00	929.00
IUUC-Pab-097641	Pongo abelii	86.44	0.00e+00	1262.00
IUUC-Pva-102819	Pteropus vampyrus	90.04	0.00e+00	1118.00
IUUC-Pte-104123	Pyrenophora teres	42.86	2.00e-10	62.00
IUUC-Pyt-104567	Pyrenophora triticirepentis	42.86	2.00e-10	62.00
IUUC-Rno-106099	Rattus norvegicus	88.72	0.00e+00	1232.00
IUUC-Sha-106845	Sarcophilus harrisii	81.53	0.00e+00	1190.00
IUUC-Sly-111123	Solanum lycopersicum	46.15	8.00e-10	57.80
IUUC-Stu-112434	Solanum tuberosum	46.15	9.00e-10	57.80
IUUC-Ssc-116036	Sus scrofa	82.42	0.00e+00	1189.00
IUUC-Tgu-117498	Taeniopygia guttata	88.59	0.00e+00	1264.00
IUUC-Tru-118278	Takifugu rubripes	70.95	0.00e+00	1022.00
IUUC-Tsy-118990	Tarsius syrichta	94.91	0.00e+00	975.00
IUUC-Tni-120852	Tetraodon nigroviridis	75.12	0.00e+00	896.00
IUUC-Ttr-128922	Tursiops truncatus	90.07	0.00e+00	1094.00
IUUC-Xtr-132012	Xenopus tropicalis	80.92	0.00e+00	1049.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence