iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004483

Ensembl Protein ID

ENSACAP00000001018.2

UniProt Accession

H9G4N7; H9G4N7_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

fgr

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000000905.3	ENSACAT00000001047.3	ENSACAP00000001018.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.70e-16	57.7	90	146

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++lydyea ++d+Lt+ kG++ ++i  ++++++W+++ +  +g  G +P+n+v+ ++
   Q: 90   LFIALYDYEARTEDDLTFVKGEKFHII--NNTEGDWWEARSLSTGATGYIPSNYVAPVD 146
           5789***********************..8999**********************9987 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MGCVQCKKKK TNKAQSNSGD GTPNPPPSSC YNPDPTQQNA PNSFTRIPDF NNFQGTPGPS 60
TPAFMGGSGV YPTPSLHMPG AGITGGGVTL FIALYDYEAR TEDDLTFVKG EKFHIINNTE 120

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Nucleotide Sequence
(Fasta)

ATGGGTTGTG TGCAATGCAA GAAAAAGAAG ACGAATAAGG CCCAGAGTAA CAGTGGCGAC 60
GGAACACCGA ACCCGCCTCC CAGCTCCTGC TACAACCCTG ACCCGACCCA GCAGAATGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011816	Astyanax mexicanus	80.51	0.00e+00	883.00
IUUC-Eca-033581	Equus caballus	73.03	0.00e+00	803.00
IUUC-Fal-036786	Ficedula albicollis	91.30	0.00e+00	942.00
IUUC-Gga-040762	Gallus gallus	87.71	0.00e+00	958.00
IUUC-Loc-052620	Lepisosteus oculatus	85.69	0.00e+00	946.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence