iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
POPTR_0001s37730	POPTR_0001s37730.1	POPTR_0001s37730.1
POPTR_0001s37730	POPTR_0001s37730.2	POPTR_0001s37730.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-119	399.7	2259	2597
UBD/Alpha-Helix/UBA	7.70e-09	36.5	191	230

Active Site

Position(s)	Description	Evidence
3298	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           +dl+ rl+v+f+gEeg+d+gG+tre+++lls+ ++++ + lf ++ +++ t+qpnp+s ++ +ehl++F+f+Gr+++kal+dg+lld+ 
   Q: 2259 QDLRGRLNVQFQGEEGIDAGGLTREWYQLLSRVVFDKGALLF-TTVGNNVTFQPNPNSVYQ-TEHLSYFKFVGRVVAKALFDGQLLDVY 2345
           7999**********************************9999.666789999******986.5************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.......lgetkeeeLkpgGenipVtneNkeeY 173
           +++sfyk++lg+k++++d+e+vdp++yk+lk+++en+ s + +    ltfs++ ++         +++++eLkpgG+ni+Vt+e k+eY
   Q: 2346 FTRSFYKHILGVKVTYHDIEAVDPDYYKNLKWMLENDVSCVPD----LTFSMDADEekhilyeKTQVTDYELKPGGRNIRVTEETKHEY 2430
           **********************************995444444....444433333336684444555677****************** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           v+lv++++l++ i+ q+++f eGfne++p el+s+F+ +elelli+G +eid++dlk++t+y+g yt+ s++iqwFwev+++f++e+ +
   Q: 2431 VDLVADHILTNAIRPQITSFLEGFNELVPRELISIFNDKELELLISGLPEIDLDDLKANTEYTG-YTSASSVIQWFWEVVKGFNKEDMA 2518
           **************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           ++LqFvTg+s++Pl+Gf++l+    p++f+i+k +++++rlPs++TCfn+L+LPeY+s e+l+e+Ll+Ai+e+ +gF++
   Q: 2519 RLLQFVTGTSKVPLEGFKALQgisgPQKFQIHKaYGAPERLPSAHTCFNQLDLPEYTSREQLQERLLLAIHEAsEGFGF 2597
           *********************************99999***********************************9***85 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           de  ++ +veMGF+r +a +aLr+   n++e+A+e+L+++
   Q: 191  DENTIATIVEMGFTRARAEEALRRVeTNSVEMAMEWLFSH 230
           78899*******************66************97 PP

Organism

Populus trichocarpa

Protein Sequence
(Fasta)

MAALTFDSRR RTCYAAMVNN FYVHGTFREL LTTFEATSQL LWTLPYPFPT PSVDQEKAGE 60
GNNLSHSTWL LDTLHSYCRA LEYFVNSSLL LSSTSASQAQ LLVQPVAVGL SIGLFPVPKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAAACCGT CGAAGGGCTG ATGTCGGATC GTTGAGTGCA GCTTCAAAGA CATTGGGAAC 60
CACCTTGGCT AAAATATTTC TTGAAGCTCT CAGTTTCTCT GGGTATTCTA CTACTGGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM

Pfam

PF14377--DUF4414
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001684	Ailuropoda melanoleuca	53.16	6.00e-128	453.00
IUUC-Apl-003752	Anas platyrhynchos	44.74	8.00e-94	337.00
IUUC-Aca-005263	Anolis carolinensis	52.93	7.00e-128	453.00
IUUC-Ani-009412	Aspergillus nidulans	32.56	4.00e-150	527.00
IUUC-Ame-011067	Astyanax mexicanus	53.15	5.00e-127	450.00
IUUC-Bta-012813	Bos taurus	53.16	7.00e-128	453.00
IUUC-Cel-018179	Caenorhabditis elegans	48.25	3.00e-119	424.00
IUUC-Cja-018741	Callithrix jacchus	53.27	2.00e-127	451.00
IUUC-Cfa-020083	Canis familiaris	53.16	7.00e-128	453.00
IUUC-Cpo-021923	Cavia porcellus	44.49	2.00e-93	338.00
IUUC-Csa-023853	Chlorocebus sabaeus	53.16	7.00e-128	453.00
IUUC-Cho-024718	Choloepus hoffmanni	54.71	3.00e-118	421.00
IUUC-Csv-025872	Ciona savignyi	50.00	1.00e-117	415.00
IUUC-Dre-028525	Danio rerio	51.91	4.00e-113	404.00
IUUC-Dno-029680	Dasypus novemcinctus	53.16	5.00e-128	453.00
IUUC-Dor-030902	Dipodomys ordii	47.78	5.00e-109	390.00
IUUC-Dme-032122	Drosophila melanogaster	50.82	6.00e-123	437.00
IUUC-Eca-033915	Equus caballus	52.58	6.00e-126	447.00
IUUC-Eeu-034963	Erinaceus europaeus	52.80	7.00e-126	446.00
IUUC-Fca-035824	Felis catus	53.16	8.00e-128	453.00
IUUC-Fal-037126	Ficedula albicollis	44.50	5.00e-93	335.00
IUUC-Gmo-039073	Gadus morhua	53.40	2.00e-128	455.00
IUUC-Gga-040309	Gallus gallus	57.37	8.00e-99	352.00
IUUC-Gac-042430	Gasterosteus aculeatus	53.40	2.00e-128	455.00
IUUC-Hsa-046879	Homo sapiens	53.16	7.00e-128	453.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	53.16	3.00e-128	453.00
IUUC-Lch-050252	Latimeria chalumnae	53.50	2.00e-127	452.00
IUUC-Loc-052472	Lepisosteus oculatus	53.40	2.00e-128	455.00
IUUC-Laf-054154	Loxodonta africana	53.16	7.00e-128	453.00
IUUC-Mcc-055085	Macaca mulatta	53.16	6.00e-128	453.00
IUUC-Mla-058888	Melampsora laricipopulina	46.72	9.00e-115	406.00
IUUC-Mga-060190	Meleagris gallopavo	44.08	2.00e-93	337.00
IUUC-Mvi-060320	Microbotryum violaceum	33.10	4.00e-125	444.00
IUUC-Mmr-060820	Microcebus murinus	53.16	5.00e-128	454.00
IUUC-Mdo-062930	Monodelphis domestica	53.16	3.00e-128	454.00
IUUC-Mmu-063601	Mus musculus	53.16	5.00e-128	453.00
IUUC-Mpu-066653	Mustela putorius furo	53.16	6.00e-128	453.00
IUUC-Mlu-067418	Myotis lucifugus	53.16	9.00e-128	452.00
IUUC-Nfi-068278	Neosartorya fischeri	33.69	2.00e-151	531.00
IUUC-Nle-069418	Nomascus leucogenys	53.16	7.00e-128	453.00
IUUC-Opr-070443	Ochotona princeps	44.39	1.00e-93	338.00
IUUC-Ont-071300	Oreochromis niloticus	53.40	2.00e-128	455.00
IUUC-Oan-073046	Ornithorhynchus anatinus	52.91	1.00e-126	449.00
IUUC-Ocu-074178	Oryctolagus cuniculus	53.16	2.00e-128	454.00
IUUC-Ome-081289	Oryza meridionalis	68.78	0.00e+00	1110.00
IUUC-Olu-087813	Ostreococcus lucimarinus	53.53	1.00e-127	448.00
IUUC-Oga-088903	Otolemur garnettii	53.16	6.00e-128	453.00
IUUC-Oar-090210	Ovis aries	53.16	7.00e-128	453.00
IUUC-Ptr-091629	Pan troglodytes	44.53	2.00e-93	337.00
IUUC-Pan-092368	Papio anubis	51.91	1.00e-113	406.00
IUUC-Pfo-096232	Poecilia formosa	53.40	1.00e-128	456.00
IUUC-Pab-098583	Pongo abelii	53.16	6.00e-128	453.00
IUUC-Pca-100596	Procavia capensis	42.65	3.00e-90	326.00
IUUC-Pva-102116	Pteropus vampyrus	49.06	2.00e-113	405.00
IUUC-Pgr-103465	Puccinia graminis	41.11	4.00e-125	444.00
IUUC-Ptt-103813	Puccinia triticina	38.08	2.00e-115	412.00
IUUC-Sha-106961	Sarcophilus harrisii	53.16	4.00e-128	454.00
IUUC-Spo-108024	Schizosaccharomyces pombe	32.55	4.00e-134	473.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	45.74	6.00e-98	351.00
IUUC-Stu-112501	Solanum tuberosum	76.00	3.00e-151	527.00
IUUC-Sar-113291	Sorex araneus	52.62	4.00e-123	437.00
IUUC-Ssc-115754	Sus scrofa	53.16	8.00e-128	453.00
IUUC-Tgu-116632	Taeniopygia guttata	44.74	3.00e-94	339.00
IUUC-Tru-118570	Takifugu rubripes	53.40	1.00e-128	456.00
IUUC-Tsy-118806	Tarsius syrichta	44.13	5.00e-91	329.00
IUUC-Tni-120836	Tetraodon nigroviridis	52.69	5.00e-125	443.00
IUUC-Tbe-127793	Tupaia belangeri	41.94	3.00e-87	316.00
IUUC-Ttr-129253	Tursiops truncatus	53.16	1.00e-127	452.00
IUUC-Vpa-130708	Vicugna pacos	53.16	1.00e-127	452.00
IUUC-Xtr-132123	Xenopus tropicalis	50.81	1.00e-115	412.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence