iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-073814

Ensembl Protein ID

ENSOCUP00000011293.3

UniProt Accession

G1T4R9; G1T4R9_RABIT

Genbank Protein ID

ENSOCUP00000011293

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AAGW02055216

Gene Name

PLCG2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000013105.3	ENSOCUT00000013117.3	ENSOCUP00000011293.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-10	41.1	774	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy+a+++deL++ +G  ++ +   ++ +gW+kg    +  +  fP+n+ve ++
   Q: 774  RTVKALYDYKAKQSDELSFCRGALIHNV--SKEPGGWWKGD-YGTRIQQYFPSNYVEDIS 830
           789************************9..77889*****6.55556679******9985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAMPTMVNVE ALPEYEKSQI KRALELGTVM TVFSFRKCTP ERRTVQVIME TRQVAWSKTA 60
DKIEGFLDIM DIKEIRPGKN SKDFERAKAV RQKEDCCFTL LYGTQFVLST LSLAADSKED 120

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Nucleotide Sequence
(Fasta)

CCTCCTCAGT TCTCCCGAGT GCTCCCTTCG CCCTGAAGAA GATGGCAATG CCCACCATGG 60
TGAACGTGGA GGCCCTCCCG GAATACGAGA AGAGCCAGAT CAAGAGAGCC CTGGAGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0032237--P:activation of store-operated calcium channel activity
GO:0050853--P:B cell receptor signaling pathway
GO:0002316--P:follicular B cell differentiation
GO:0032959--P:inositol trisphosphate biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0043069--P:negative regulation of programmed cell death
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0002092--P:positive regulation of receptor internalization
GO:0032481--P:positive regulation of type I interferon production
GO:0010468--P:regulation of gene expression
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0032496--P:response to lipopolysaccharide
GO:0050852--P:T cell receptor signaling pathway

KEGG

ocu:100340139

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	81.80	0.00e+00	1998.00
IUUC-Aca-004266	Anolis carolinensis	78.92	0.00e+00	2093.00
IUUC-Ame-011540	Astyanax mexicanus	58.41	0.00e+00	1425.00
IUUC-Bta-013196	Bos taurus	92.84	0.00e+00	2356.00
IUUC-Cpo-021890	Cavia porcellus	91.81	0.00e+00	2459.00
IUUC-Csa-024233	Chlorocebus sabaeus	93.36	0.00e+00	2476.00
IUUC-Dre-028650	Danio rerio	58.73	0.00e+00	1440.00
IUUC-Dno-028871	Dasypus novemcinctus	93.44	0.00e+00	2408.00
IUUC-Eca-033458	Equus caballus	94.55	0.00e+00	2496.00
IUUC-Eeu-035329	Erinaceus europaeus	89.11	0.00e+00	2363.00
IUUC-Fal-037390	Ficedula albicollis	81.46	0.00e+00	2154.00
IUUC-Gga-040918	Gallus gallus	81.62	0.00e+00	2132.00
IUUC-Ggo-045625	Gorilla gorilla	92.65	0.00e+00	2474.00
IUUC-Hsa-046129	Homo sapiens	93.83	0.00e+00	2519.00
IUUC-Loc-052025	Lepisosteus oculatus	61.39	0.00e+00	1576.00
IUUC-Mcc-054831	Macaca mulatta	93.35	0.00e+00	2411.00
IUUC-Mga-059368	Meleagris gallopavo	81.77	0.00e+00	2117.00
IUUC-Mmr-060898	Microcebus murinus	90.40	0.00e+00	2252.00
IUUC-Mmu-064334	Mus musculus	92.81	0.00e+00	2451.00
IUUC-Mlu-067230	Myotis lucifugus	93.92	0.00e+00	2505.00
IUUC-Nle-069318	Nomascus leucogenys	87.99	0.00e+00	2283.00
IUUC-Opr-070718	Ochotona princeps	84.06	0.00e+00	1136.00
IUUC-Ola-086501	Oryzias latipes	57.39	0.00e+00	1447.00
IUUC-Oga-088036	Otolemur garnettii	93.44	0.00e+00	1800.00
IUUC-Oar-089556	Ovis aries	92.62	0.00e+00	2357.00
IUUC-Ptr-091001	Pan troglodytes	93.83	0.00e+00	2516.00
IUUC-Pan-092744	Papio anubis	93.60	0.00e+00	2479.00
IUUC-Psi-093987	Pelodiscus sinensis	81.70	0.00e+00	2154.00
IUUC-Pfo-096249	Poecilia formosa	58.24	0.00e+00	1486.00
IUUC-Pab-098268	Pongo abelii	91.23	0.00e+00	2427.00
IUUC-Pva-102939	Pteropus vampyrus	91.00	0.00e+00	2287.00
IUUC-Ssc-115308	Sus scrofa	88.39	0.00e+00	2166.00
IUUC-Tgu-116811	Taeniopygia guttata	81.54	0.00e+00	2151.00
IUUC-Tru-117536	Takifugu rubripes	57.27	0.00e+00	1428.00
IUUC-Tsy-119139	Tarsius syrichta	84.92	0.00e+00	978.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence