iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059212

Ensembl Protein ID

ENSMGAP00000017929.1

UniProt Accession

G3UQJ0; G3UQJ0_MELGA

Protein Name

Uncharacterized protein

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000002363.2	ENSMGAT00000019958.1	ENSMGAP00000017929.1
ENSMGAG00000002363.2	ENSMGAT00000002666.2	ENSMGAP00000001995.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.30e-13	47.8	460	511

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +lydy++  dde ++   d+++ i  e  degW++g  + +gk GlfP+n+v+ l
   Q: 460  VALYDYQGDGDDEISFDPDDTITHI--EMVDEGWWRG--QCHGKVGLFPANYVKLL 511
           58***********************..9*********..7*************977 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MWKAVVGHDV SVKVEAQSDD WDTDPDFVVS ACGGGQRGGL QDPAAQRCSP PRSIHQLRSR 60
VSEEHEVIKK KELESGPKAS YGYGGKFGTE RDRMDKNSPG SILTAQISSL LSSRHAALGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAGG CGGTCGTGGG CCACGACGTA TCGGTGAAGG TGGAAGCACA GAGTGATGAC 60
TGGGACACCG ACCCCGACTT TGTGGTGAGC GCCTGTGGTG GGGGTCAGCG TGGGGGGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Gga-040335	Gallus gallus	61.54	4.00e-146	511.00
IUUC-Tre-122167	Trichoderma reesei	59.18	7.00e-12	65.90
IUUC-Tvi-122614	Trichoderma virens	59.18	4.00e-12	66.20
IUUC-Vda-129766	Verticillium dahliae	56.14	7.00e-14	72.40

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence