iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073486

Ensembl Protein ID

ENSOANP00000015968.2

UniProt Accession

F6UG60; F6UG60_ORNAN

Protein Name

Tyrosine-protein kinase

Gene Name

FGR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000010074.2	ENSOANT00000015971.2	ENSOANP00000015968.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-13	50.5	82	138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++lydyea ++++L++ kG++ +++  ++ +++W+++ +  +g +G +P+n+v+ ++
   Q: 82   LFIALYDYEARTSEDLSFSKGEKFHIL--NSAEGDWWEARSLSSGLSGYIPSNYVAPMD 138
           689************************..88999*********************9875 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MGCVQCKKNS EVGTKGEASG SSDGTGGFAF RDRYGPDPTQ THPPISTTRI PDYNNFTPSP 60
VTSTFMSTSG LRPGAISGGA TLFIALYDYE ARTSEDLSFS KGEKFHILNS AEGDWWEARS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGGGCTCC TTCTTTTTCT GCCCCAGGTG AGCCCAAAAT GGGCTGTGTG CAGTGCAAGA 60
AGAACTCAGA GGTGGGAACC AAAGGAGAGG CTTCAGGAAG CAGCGATGGC ACCGGCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0050830--P:defense response to Gram-positive bacterium
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

oaa:100092688

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001938	Ailuropoda melanoleuca	79.40	0.00e+00	864.00
IUUC-Bta-012607	Bos taurus	78.07	0.00e+00	863.00
IUUC-Cja-018914	Callithrix jacchus	77.04	0.00e+00	848.00
IUUC-Cfa-020165	Canis familiaris	77.34	0.00e+00	853.00
IUUC-Cpo-021476	Cavia porcellus	77.08	0.00e+00	850.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	29.91	8.00e-17	80.90
IUUC-Csa-023692	Chlorocebus sabaeus	77.32	0.00e+00	867.00
IUUC-Dno-028920	Dasypus novemcinctus	78.07	0.00e+00	858.00
IUUC-Eca-033581	Equus caballus	80.53	0.00e+00	888.00
IUUC-Fca-036499	Felis catus	79.73	0.00e+00	874.00
IUUC-Ggo-044640	Gorilla gorilla	76.94	0.00e+00	857.00
IUUC-Hsa-046751	Homo sapiens	76.94	0.00e+00	857.00
IUUC-Itr-048218	Ictidomys tridecemlineatus	77.32	0.00e+00	846.00
IUUC-Laf-054128	Loxodonta africana	78.65	0.00e+00	878.00
IUUC-Mcc-054715	Macaca mulatta	76.94	0.00e+00	860.00
IUUC-Meu-056155	Macropus eugenii	80.71	0.00e+00	766.00
IUUC-Mmr-060615	Microcebus murinus	78.76	0.00e+00	860.00
IUUC-Mmu-063286	Mus musculus	74.53	0.00e+00	828.00
IUUC-Mac-064532	Musa acuminata	33.48	5.00e-20	92.40
IUUC-Mpu-066641	Mustela putorius furo	79.02	0.00e+00	863.00
IUUC-Ocu-074552	Oryctolagus cuniculus	78.58	0.00e+00	871.00
IUUC-Obr-076585	Oryza brachyantha	33.33	7.00e-21	95.10
IUUC-Oga-088731	Otolemur garnettii	78.07	0.00e+00	860.00
IUUC-Oar-090207	Ovis aries	78.26	0.00e+00	861.00
IUUC-Ptr-090979	Pan troglodytes	76.75	0.00e+00	854.00
IUUC-Pan-092188	Papio anubis	77.13	0.00e+00	861.00
IUUC-Pfo-096519	Poecilia formosa	77.54	0.00e+00	826.00
IUUC-Pab-098617	Pongo abelii	76.75	0.00e+00	858.00
IUUC-Pca-100834	Procavia capensis	70.47	0.00e+00	755.00
IUUC-Rno-104945	Rattus norvegicus	73.97	0.00e+00	810.00
IUUC-Sha-107103	Sarcophilus harrisii	75.80	0.00e+00	825.00
IUUC-Sit-110451	Setaria italica	34.40	5.00e-22	99.00
IUUC-Stu-112056	Solanum tuberosum	30.37	2.00e-15	77.00
IUUC-Sbi-114267	Sorghum bicolor	33.05	2.00e-21	97.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence