iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	HINT	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-10	42.5	604	664

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v++ y++ a ++ e +l++G  v+++  ++++ + +W     e +g+rG +P+ F ++++
   Q: 604  MNQVIAAYPFVARSSHEVSLQAGQPVTILeaQDKKGNPEWSLV--EVNGQRGYVPSGFLARAR 664
           799**************************9889999****977..9************99875 PP

Organism

Homo sapiens

Functional Description
(View)

May act as a guanine nucleotide exchange factor (GEF).

Protein Sequence
(Fasta)

MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL 60
QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV QLVGNIFLEF QEELEQVYKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGTAGCAG AGCCTAGCTA ATTACCCTTC ATAATTAGAA TTGTCCTATC TACTACGGAG 60
TGTTATAGAC CCTCTTTCCA CAGGAGGGGA AGAAAGAAAG AAGCCGGAAT CCCCCTGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50010--DH_2
PS50002--SH3

Pfam

PF00621--RhoGEF
PF00018--SH3_1
PF07653--SH3_2

SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

KEGG

hsa:389337

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011907	Astyanax mexicanus	39.22	4.00e-128	452.00
IUUC-Bta-012848	Bos taurus	85.93	0.00e+00	1125.00
IUUC-Cfa-021281	Canis familiaris	84.59	0.00e+00	1103.00
IUUC-Csa-023043	Chlorocebus sabaeus	96.00	0.00e+00	1273.00
IUUC-Dre-028496	Danio rerio	39.14	6.00e-126	444.00
IUUC-Ete-032921	Echinops telfairi	62.93	7.00e-73	266.00
IUUC-Ggo-044900	Gorilla gorilla	98.37	0.00e+00	1301.00
IUUC-Lch-050096	Latimeria chalumnae	46.46	7.00e-168	584.00
IUUC-Loc-051937	Lepisosteus oculatus	41.65	4.00e-134	472.00
IUUC-Mcc-054950	Macaca mulatta	95.26	0.00e+00	1263.00
IUUC-Meu-056383	Macropus eugenii	69.23	7.00e-173	600.00
IUUC-Mdo-062021	Monodelphis domestica	68.06	0.00e+00	884.00
IUUC-Mmu-064186	Mus musculus	79.44	0.00e+00	1036.00
IUUC-Ptr-090508	Pan troglodytes	98.67	0.00e+00	1304.00
IUUC-Pan-092517	Papio anubis	95.70	0.00e+00	1246.00
IUUC-Pfo-096703	Poecilia formosa	39.29	2.00e-123	436.00
IUUC-Pab-098542	Pongo abelii	98.22	0.00e+00	1294.00
IUUC-Rno-105455	Rattus norvegicus	80.92	0.00e+00	1058.00
IUUC-Sha-106562	Sarcophilus harrisii	67.66	0.00e+00	870.00
IUUC-Ttr-128242	Tursiops truncatus	82.37	0.00e+00	1086.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence