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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064369
UUCD1 version UUC-MuM-00567
Ensembl Protein ID ENSMUSP00000058233.6
UniProt Accession Q7TQF2; A2ANI6; Q6AXG0; Q7TQM0; FBX10_MOUSE
Genbank Protein ID CAM17797.1; AAH52485.1; AAH54731.1; AAH79571.1
Protein Name F-box only protein 10
Genbank Nucleotide ID AL824706; BC052485; BC054731; BC079571
Gene Name Fbxo10; Gm634
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048232.12 ENSMUST00000052236.12 ENSMUSP00000058233.6
ENSMUSG00000048232.12 ENSMUST00000140008.1 ENSMUSP00000119862.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 92.57 0.00e+00 1746.00 IUUC-Hsa-045742
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
Protein Sequence
(Fasta)
METGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW 60
PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL FRRKKERRTL SVGPGHEFDS 120
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Protein Fasta Sequence


>IUUC-Mmu-064369|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGGGCGGGG CTCGCGGCGA AGTCGGACCC CGCTGTGGCC GAGCGCCGCA GTCCTCCGGC 60
AGCCCTGCGG CTTCCAGGGC GTCGCGGCCG CGGCCGGGCA GCGCCGCTCC CTGAGGTAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064369|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR006633--Carb-bd_sugar_hydrolysis-dom
IPR001810--F-box_dom
IPR007742--NosD_dom
IPR022441--Para_beta_helix_rpt-2
IPR006626--PbH1
IPR012334--Pectin_lyas_fold
IPR011050--Pectin_lyase_fold/virulence
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF05048--NosD
SMART

SM00722--CASH
SM00256--FBOX
SM00710--PbH1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042981--P:regulation of apoptotic process
KEGG mmu:269529
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001558 Ailuropoda melanoleuca 92.57 0.00e+00 1727.00
IUUC-Aca-004917 Anolis carolinensis 65.05 0.00e+00 1243.00
IUUC-Ame-011129 Astyanax mexicanus 51.62 0.00e+00 957.00
IUUC-Bta-012928 Bos taurus 88.55 0.00e+00 1620.00
IUUC-Cja-019383 Callithrix jacchus 92.38 0.00e+00 1158.00
IUUC-Cfa-020855 Canis familiaris 91.53 0.00e+00 1694.00
IUUC-Cpo-021873 Cavia porcellus 90.29 0.00e+00 1686.00
IUUC-Cre-022959 Chlamydomonas reinhardtii 22.64 9.60e-02 32.00
IUUC-Csa-024199 Chlorocebus sabaeus 92.57 0.00e+00 1743.00
IUUC-Dre-028495 Danio rerio 51.41 0.00e+00 958.00
IUUC-Dno-029707 Dasypus novemcinctus 91.00 0.00e+00 1721.00
IUUC-Dor-030668 Dipodomys ordii 88.20 0.00e+00 1664.00
IUUC-Ete-032489 Echinops telfairi 78.85 0.00e+00 912.00
IUUC-Eca-033534 Equus caballus 91.32 0.00e+00 1721.00
IUUC-Eeu-034536 Erinaceus europaeus 77.75 1.00e-156 547.00
IUUC-Fca-035906 Felis catus 92.57 0.00e+00 1724.00
IUUC-Gmo-039471 Gadus morhua 44.67 0.00e+00 679.00
IUUC-Gac-041496 Gasterosteus aculeatus 43.19 3.00e-180 625.00
IUUC-Ggo-044503 Gorilla gorilla 92.47 0.00e+00 1739.00
IUUC-Hsa-045742 Homo sapiens 92.57 0.00e+00 1739.00
IUUC-Itr-048727 Ictidomys tridecemlineatus 93.72 0.00e+00 1758.00
IUUC-Lch-049641 Latimeria chalumnae 64.40 0.00e+00 1245.00
IUUC-Loc-052060 Lepisosteus oculatus 54.77 0.00e+00 1023.00
IUUC-Laf-054216 Loxodonta africana 92.67 0.00e+00 1741.00
IUUC-Mcc-055122 Macaca mulatta 92.57 0.00e+00 1741.00
IUUC-Meu-056537 Macropus eugenii 63.41 0.00e+00 745.00
IUUC-Mmr-061489 Microcebus murinus 92.26 0.00e+00 1701.00
IUUC-Mdo-062954 Monodelphis domestica 66.05 0.00e+00 1297.00
IUUC-Mpu-065774 Mustela putorius furo 92.05 0.00e+00 1717.00
IUUC-Mlu-067093 Myotis lucifugus 94.12 0.00e+00 1749.00
IUUC-Nle-068989 Nomascus leucogenys 89.64 0.00e+00 1671.00
IUUC-Opr-070263 Ochotona princeps 88.24 0.00e+00 1743.00
IUUC-Ont-071949 Oreochromis niloticus 52.95 0.00e+00 967.00
IUUC-Oan-073316 Ornithorhynchus anatinus 59.35 2.00e-102 365.00
IUUC-Ocu-074369 Oryctolagus cuniculus 93.59 0.00e+00 1751.00
IUUC-Ome-081815 Oryza meridionalis 43.18 1.80e-01 33.50
IUUC-Ola-086354 Oryzias latipes 50.98 0.00e+00 910.00
IUUC-Olu-087743 Ostreococcus lucimarinus 31.11 2.00e-04 40.80
IUUC-Oga-088392 Otolemur garnettii 92.68 0.00e+00 1740.00
IUUC-Oar-089595 Ovis aries 88.66 0.00e+00 1626.00
IUUC-Ptr-091635 Pan troglodytes 92.47 0.00e+00 1737.00
IUUC-Pan-091939 Papio anubis 92.47 0.00e+00 1738.00
IUUC-Psi-093872 Pelodiscus sinensis 70.45 5.00e-137 480.00
IUUC-Pma-094149 Petromyzon marinus 44.84 9.00e-124 437.00
IUUC-Ppa-095311 Physcomitrella patens 42.86 6.10e-02 32.30
IUUC-Pfo-097082 Poecilia formosa 50.80 0.00e+00 934.00
IUUC-Pab-098093 Pongo abelii 90.39 0.00e+00 1688.00
IUUC-Pca-101065 Procavia capensis 87.02 0.00e+00 1665.00
IUUC-Pva-102398 Pteropus vampyrus 88.49 0.00e+00 1075.00
IUUC-Rno-105341 Rattus norvegicus 98.32 0.00e+00 1819.00
IUUC-Sha-107170 Sarcophilus harrisii 62.57 0.00e+00 946.00
IUUC-Sar-112976 Sorex araneus 87.31 2.00e-129 456.00
IUUC-Ssc-115623 Sus scrofa 68.23 0.00e+00 1069.00
IUUC-Tru-118657 Takifugu rubripes 52.52 0.00e+00 965.00
IUUC-Tsy-119410 Tarsius syrichta 77.90 1.00e-180 626.00
IUUC-Tni-119696 Tetraodon nigroviridis 51.87 0.00e+00 969.00
IUUC-Tca-121485 Theobroma cacao 47.06 1.20e-02 34.70
IUUC-Tbe-128027 Tupaia belangeri 92.96 0.00e+00 1009.00
IUUC-Ttr-129142 Tursiops truncatus 88.20 0.00e+00 862.00
IUUC-Vpa-130738 Vicugna pacos 75.20 3.00e-104 372.00
IUUC-Xtr-132546 Xenopus tropicalis 63.16 0.00e+00 1251.00
Created Date 25-Jun-2017

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