iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040884

Ensembl Protein ID

ENSGALP00000054725.1

UniProt Accession

Q8UUX6; Q8UUX6_CHICK

Genbank Protein ID

AAL06249.1; CAH65203.1

Protein Name

GDP/GTP exchange factor VAV3

Genbank Nucleotide ID

AADN04000104; AJ851569

Gene Name

VAV3; RCJMB04_7l6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000039327.1	ENSGALT00000081334.1	ENSGALP00000054725.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.20e-14	53.5	793	844

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 793  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 844
           578*********************9.999999*****..9*************86 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MEPWKQCGQW LISCKVLPPN HRVTWETAQV FDLAQTLRDG VLLCQLLNNL RSHSINLKEI 60
NLRPQMSQFL CLKNIRTFLS ACCEIFGMKK SELFEAFDLF DVRDFGKVIE TLSKLSRTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGGCGCA GCGGGGGCCG CCGCGGCCGC AGCGTGGCGG GGATGGAGCC GTGGAAGCAG 60
TGCGGGCAGT GGCTGATCAG CTGCAAGGTG CTGCCGCCCA ACCACCGGGT CACCTGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

KEGG

gga:373939

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	86.30	0.00e+00	1450.00
IUUC-Apl-003734	Anas platyrhynchos	96.92	0.00e+00	1503.00
IUUC-Aca-004477	Anolis carolinensis	85.35	0.00e+00	1457.00
IUUC-Ath-007340	Arabidopsis thaliana	50.00	1.20e-02	34.30
IUUC-Ame-011279	Astyanax mexicanus	66.75	0.00e+00	1130.00
IUUC-Bta-012722	Bos taurus	85.60	0.00e+00	1444.00
IUUC-Cel-018578	Caenorhabditis elegans	28.96	8.00e-96	345.00
IUUC-Cja-018941	Callithrix jacchus	85.94	0.00e+00	1429.00
IUUC-Cfa-020266	Canis familiaris	86.45	0.00e+00	1286.00
IUUC-Cpo-021966	Cavia porcellus	85.31	0.00e+00	1247.00
IUUC-Csa-023892	Chlorocebus sabaeus	85.42	0.00e+00	1314.00
IUUC-Dre-028199	Danio rerio	66.13	0.00e+00	1123.00
IUUC-Dno-029474	Dasypus novemcinctus	86.19	0.00e+00	1453.00
IUUC-Eca-033961	Equus caballus	86.05	0.00e+00	1309.00
IUUC-Eeu-034719	Erinaceus europaeus	67.59	0.00e+00	700.00
IUUC-Fca-036572	Felis catus	86.09	0.00e+00	1411.00
IUUC-Fal-036802	Ficedula albicollis	93.14	0.00e+00	1618.00
IUUC-Gmo-039409	Gadus morhua	69.21	0.00e+00	1165.00
IUUC-Gac-041395	Gasterosteus aculeatus	72.39	0.00e+00	1261.00
IUUC-Ggo-044460	Gorilla gorilla	83.46	0.00e+00	1240.00
IUUC-Hsa-046099	Homo sapiens	83.31	0.00e+00	1433.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	82.10	0.00e+00	1254.00
IUUC-Lch-049650	Latimeria chalumnae	82.16	5.00e-108	382.00
IUUC-Loc-052487	Lepisosteus oculatus	73.51	0.00e+00	1259.00
IUUC-Laf-054564	Loxodonta africana	86.30	0.00e+00	1451.00
IUUC-Mcc-054622	Macaca mulatta	82.97	0.00e+00	1425.00
IUUC-Meu-056680	Macropus eugenii	79.20	0.00e+00	1328.00
IUUC-Mga-060013	Meleagris gallopavo	93.26	0.00e+00	1557.00
IUUC-Mmr-061251	Microcebus murinus	82.21	0.00e+00	1457.00
IUUC-Mdo-061875	Monodelphis domestica	85.93	0.00e+00	1458.00
IUUC-Mmu-063735	Mus musculus	85.83	0.00e+00	1473.00
IUUC-Mpu-065856	Mustela putorius furo	86.66	0.00e+00	1456.00
IUUC-Mlu-068108	Myotis lucifugus	82.17	0.00e+00	1384.00
IUUC-Nle-069863	Nomascus leucogenys	81.82	0.00e+00	1393.00
IUUC-Opr-070372	Ochotona princeps	74.76	0.00e+00	926.00
IUUC-Ont-072286	Oreochromis niloticus	72.47	0.00e+00	1238.00
IUUC-Ocu-074194	Oryctolagus cuniculus	85.95	0.00e+00	1453.00
IUUC-Ola-086336	Oryzias latipes	71.23	0.00e+00	1240.00
IUUC-Oga-089104	Otolemur garnettii	59.22	0.00e+00	971.00
IUUC-Oar-089272	Ovis aries	85.60	0.00e+00	1482.00
IUUC-Ptr-090652	Pan troglodytes	83.86	0.00e+00	1433.00
IUUC-Pan-092550	Papio anubis	82.11	0.00e+00	1251.00
IUUC-Psi-093784	Pelodiscus sinensis	85.15	0.00e+00	1322.00
IUUC-Pfo-097308	Poecilia formosa	70.55	0.00e+00	1243.00
IUUC-Pab-098698	Pongo abelii	83.71	0.00e+00	1431.00
IUUC-Pva-102262	Pteropus vampyrus	85.49	0.00e+00	1385.00
IUUC-Rno-105421	Rattus norvegicus	85.01	0.00e+00	1466.00
IUUC-Sha-107325	Sarcophilus harrisii	86.29	0.00e+00	1485.00
IUUC-Sar-113456	Sorex araneus	80.64	0.00e+00	1368.00
IUUC-Ssc-115338	Sus scrofa	57.23	0.00e+00	879.00
IUUC-Tgu-116595	Taeniopygia guttata	91.22	0.00e+00	1507.00
IUUC-Tru-117884	Takifugu rubripes	65.85	0.00e+00	1177.00
IUUC-Tsy-119429	Tarsius syrichta	79.59	0.00e+00	1198.00
IUUC-Tni-119951	Tetraodon nigroviridis	69.24	0.00e+00	1160.00
IUUC-Tbe-127995	Tupaia belangeri	76.25	4.00e-162	565.00
IUUC-Ttr-128281	Tursiops truncatus	86.19	0.00e+00	1447.00
IUUC-Vpa-130066	Vicugna pacos	46.58	3.00e-34	140.00
IUUC-Xtr-132427	Xenopus tropicalis	72.39	0.00e+00	1276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence