iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.20e-48	162.7	15	153

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 4    kelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk..... 87
            elk l+++p+eg+++++vde dl++wev+i+Gp++t+Yegg+Fk++++fp dYP++PP ++fltk++hPn+ye+G+vC+sil+     
   Q: 15   LELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHppvdd 103
           599********************************************************************************999999 PP
   S: 88   ......eeekWspalsvesvllsiqsllaepnpesplneeaaellkknre 131
                 ++e+W+p+++v+++lls++sll+epn+ sp+n++a+ +++k++e
   Q: 104  pqsgelPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKE 153
           999*9******************************************998 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA 60
RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATGGCCCG GCCGCTGGTG CCCAGCTCGC AGAAGGCGCT GCTGCTGGAG CTGAAGGGGC 60
TGCAGGAGGA GCCGGTGGAG GGCTTCCGGG TGACGCTGGT GGACGAGGGC GACCTGTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0035458--P:cellular response to interferon-beta
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0090261--P:positive regulation of inclusion body assembly
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0070848--P:response to growth factor

KEGG

rno:299602

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001600	Ailuropoda melanoleuca	99.11	2.00e-129	454.00
IUUC-Ame-011425	Astyanax mexicanus	89.55	1.00e-108	385.00
IUUC-Bta-012516	Bos taurus	99.51	2.00e-120	424.00
IUUC-Cja-018852	Callithrix jacchus	90.00	2.00e-103	368.00
IUUC-Cfa-020203	Canis familiaris	100.00	1.00e-120	425.00
IUUC-Cpo-022139	Cavia porcellus	92.07	3.00e-121	427.00
IUUC-Csa-023371	Chlorocebus sabaeus	95.98	2.00e-121	427.00
IUUC-Dre-028367	Danio rerio	89.05	3.00e-108	384.00
IUUC-Dor-030875	Dipodomys ordii	96.00	6.00e-122	429.00
IUUC-Fca-035832	Felis catus	98.19	1.00e-93	334.00
IUUC-Gmo-039414	Gadus morhua	90.05	1.00e-109	388.00
IUUC-Gga-040694	Gallus gallus	93.64	7.00e-122	429.00
IUUC-Gac-042485	Gasterosteus aculeatus	88.56	5.00e-109	386.00
IUUC-Ggo-044806	Gorilla gorilla	95.98	2.00e-121	428.00
IUUC-Hsa-046245	Homo sapiens	95.98	2.00e-121	427.00
IUUC-Loc-052932	Lepisosteus oculatus	91.54	4.00e-111	393.00
IUUC-Mcc-054665	Macaca mulatta	92.41	2.00e-114	404.00
IUUC-Mga-060075	Meleagris gallopavo	93.22	2.00e-121	427.00
IUUC-Mmr-061165	Microcebus murinus	99.10	9.00e-123	432.00
IUUC-Mdo-061825	Monodelphis domestica	99.51	4.00e-120	423.00
IUUC-Mmu-064168	Mus musculus	100.00	2.00e-121	427.00
IUUC-Mpu-066009	Mustela putorius furo	99.11	5.00e-129	452.00
IUUC-Opr-070826	Ochotona princeps	90.23	2.00e-108	385.00
IUUC-Ont-071745	Oreochromis niloticus	90.15	1.00e-110	392.00
IUUC-Oan-073287	Ornithorhynchus anatinus	90.25	2.00e-116	411.00
IUUC-Ocu-074902	Oryctolagus cuniculus	95.63	2.00e-116	411.00
IUUC-Oga-088845	Otolemur garnettii	97.76	1.00e-127	448.00
IUUC-Ptr-090916	Pan troglodytes	98.65	6.00e-119	419.00
IUUC-Pan-092577	Papio anubis	95.98	2.00e-121	427.00
IUUC-Psi-093039	Pelodiscus sinensis	91.01	5.00e-87	313.00
IUUC-Pfo-096435	Poecilia formosa	89.55	9.00e-110	389.00
IUUC-Pab-098200	Pongo abelii	95.61	3.00e-110	390.00
IUUC-Pca-100169	Procavia capensis	86.43	5.00e-66	243.00
IUUC-Pva-102875	Pteropus vampyrus	100.00	6.00e-85	305.00
IUUC-Ssc-115699	Sus scrofa	89.25	7.00e-88	315.00
IUUC-Tgu-117466	Taeniopygia guttata	91.53	1.00e-119	421.00
IUUC-Tni-120864	Tetraodon nigroviridis	86.07	2.00e-105	374.00
IUUC-Xtr-132285	Xenopus tropicalis	88.61	8.00e-116	409.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence