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Tag Content
UUCD2 ID IUUC-Nle-069496
UUCD1 version UUC-NoL-00297
Ensembl Protein ID ENSNLEP00000006775.1
UniProt Accession G1R0Q4; G1R0Q4_NOMLE
Genbank Protein ID ENSNLEP00000006775
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID ADFV01013964
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000005599.2 ENSNLET00000007115.1 ENSNLEP00000006775.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.90e-125 418.7 538 869
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 538  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 625
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 626  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 711
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 712  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 799
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p+lf  +  + +  lP+sn  fn+L+LP+Y+s+e+l+ekLlyAieet+gF++
   Q: 800  TGTCRLPVGGFAELIgtgkPSLFSPSLLGLTVMLPRSNS-FNRLDLPPYKSYEQLREKLLYAIEETEGFGQ 869
           **************99999******************96.*****************************96 PP
   
Organism Nomascus leucogenys
Protein Sequence
(Fasta)
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Nle-069496|E3,HECT|Nomascus leucogenys
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCATCTG CCAGCTCTAG CCGGGCAGGA GTGGCCCTGC CTTTTGAGAA GTCTCAGCTC 60
ACTTTGAAAG GTGAGTGGCA CTGTATAATA TCTTTATCTT GTCTATGCCC AGGGAAGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Nle-069496|E3,HECT|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051224--P:negative regulation of protein transport
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 93.93 0.00e+00 1590.00
IUUC-Apl-003912 Anas platyrhynchos 75.03 0.00e+00 1196.00
IUUC-Aca-004291 Anolis carolinensis 79.10 0.00e+00 1388.00
IUUC-Bta-013231 Bos taurus 93.23 0.00e+00 1551.00
IUUC-Cja-019455 Callithrix jacchus 95.98 0.00e+00 1665.00
IUUC-Cfa-021017 Canis familiaris 94.26 0.00e+00 1577.00
IUUC-Cpo-021988 Cavia porcellus 94.03 0.00e+00 1626.00
IUUC-Csa-023549 Chlorocebus sabaeus 96.21 0.00e+00 1679.00
IUUC-Dre-028513 Danio rerio 89.14 0.00e+00 1091.00
IUUC-Dno-028976 Dasypus novemcinctus 93.35 0.00e+00 1617.00
IUUC-Dor-030176 Dipodomys ordii 90.32 0.00e+00 1466.00
IUUC-Eca-033949 Equus caballus 94.03 0.00e+00 1597.00
IUUC-Eeu-034529 Erinaceus europaeus 87.60 0.00e+00 1365.00
IUUC-Fca-036236 Felis catus 93.92 0.00e+00 1627.00
IUUC-Fal-036948 Ficedula albicollis 76.76 0.00e+00 1293.00
IUUC-Gmo-038842 Gadus morhua 86.60 0.00e+00 1026.00
IUUC-Gga-040617 Gallus gallus 78.56 0.00e+00 1390.00
IUUC-Gac-041338 Gasterosteus aculeatus 68.10 0.00e+00 1203.00
IUUC-Ggo-045278 Gorilla gorilla 97.24 0.00e+00 1694.00
IUUC-Hsa-046148 Homo sapiens 97.24 0.00e+00 1694.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 95.14 0.00e+00 1077.00
IUUC-Lch-050663 Latimeria chalumnae 76.61 0.00e+00 1346.00
IUUC-Loc-052604 Lepisosteus oculatus 73.30 0.00e+00 1271.00
IUUC-Laf-053944 Loxodonta africana 93.92 0.00e+00 1618.00
IUUC-Mcc-055655 Macaca mulatta 96.44 0.00e+00 1680.00
IUUC-Meu-055953 Macropus eugenii 78.47 0.00e+00 1339.00
IUUC-Mga-060190 Meleagris gallopavo 78.78 0.00e+00 1388.00
IUUC-Mmr-060896 Microcebus murinus 94.80 0.00e+00 1597.00
IUUC-Mdo-062536 Monodelphis domestica 88.89 0.00e+00 1558.00
IUUC-Mmu-064017 Mus musculus 94.03 0.00e+00 1608.00
IUUC-Mpu-066608 Mustela putorius furo 91.87 0.00e+00 1541.00
IUUC-Mlu-067623 Myotis lucifugus 90.70 0.00e+00 1544.00
IUUC-Opr-071054 Ochotona princeps 82.35 0.00e+00 1380.00
IUUC-Ont-071279 Oreochromis niloticus 72.10 0.00e+00 1234.00
IUUC-Oan-073512 Ornithorhynchus anatinus 86.11 0.00e+00 1445.00
IUUC-Ocu-074271 Oryctolagus cuniculus 93.47 0.00e+00 1577.00
IUUC-Ola-087237 Oryzias latipes 67.78 0.00e+00 1185.00
IUUC-Oga-088164 Otolemur garnettii 94.72 0.00e+00 1639.00
IUUC-Oar-089698 Ovis aries 93.57 0.00e+00 1561.00
IUUC-Ptr-091306 Pan troglodytes 95.98 0.00e+00 1662.00
IUUC-Pan-092814 Papio anubis 92.55 0.00e+00 1584.00
IUUC-Pfo-096709 Poecilia formosa 87.76 0.00e+00 1040.00
IUUC-Pab-098494 Pongo abelii 91.43 0.00e+00 1593.00
IUUC-Pca-100596 Procavia capensis 81.70 0.00e+00 1327.00
IUUC-Pva-103154 Pteropus vampyrus 89.30 0.00e+00 1532.00
IUUC-Rno-104954 Rattus norvegicus 93.14 0.00e+00 1368.00
IUUC-Sha-106781 Sarcophilus harrisii 89.23 0.00e+00 1600.00
IUUC-Ssc-116307 Sus scrofa 82.30 0.00e+00 1398.00
IUUC-Tgu-116530 Taeniopygia guttata 74.05 0.00e+00 1145.00
IUUC-Tru-118287 Takifugu rubripes 86.82 0.00e+00 1022.00
IUUC-Tsy-119097 Tarsius syrichta 83.89 0.00e+00 1241.00
IUUC-Tni-120801 Tetraodon nigroviridis 65.85 0.00e+00 1089.00
IUUC-Tbe-127793 Tupaia belangeri 83.70 0.00e+00 1417.00
IUUC-Ttr-128275 Tursiops truncatus 89.32 0.00e+00 1499.00
IUUC-Xtr-132866 Xenopus tropicalis 84.93 0.00e+00 1085.00
Created Date 25-Jun-2017

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