iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063960

UUCD1 version

UUC-MuM-01188

Ensembl Protein ID

ENSMUSP00000035237.6

UniProt Accession

P35123; O54704; Q8BTL9; UBP4_MOUSE

Genbank Protein ID

AAB82339.1; AAC53587.1; BAC40877.1; BAE25450.1; BAE29198.1; BAE41468.1; BAE42357.1; EDL21282.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein

Genbank Nucleotide ID

L00681; AF026469; AK089425; AK143582; AK149964; AK169933; AK171271; CH466560

Gene Name

Usp4; Unp

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032612.14	ENSMUST00000035237.11	ENSMUSP00000035237.6
ENSMUSG00000032612.14	ENSMUST00000194224.5	ENSMUSP00000141321.1
ENSMUSG00000032612.14	ENSMUST00000194959.5	ENSMUSP00000141368.1
ENSMUSG00000032612.14	ENSMUST00000193288.5	ENSMUSP00000141612.1
ENSMUSG00000032612.14	ENSMUST00000195608.1	ENSMUSP00000141411.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-112	377.4	302	922
ULD/UDP/UBQ/UBQ_Other	2.40e-16	60.5	143	221

Active Site

Position(s)	Description	Evidence
311	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
880	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l+e++l+ +++ ++n++np ++kge+++++++l++++w++++++v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTEYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laf+ld+l+e+l++ k+kp+ e ++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFILDGLHEDLNRVKKKPYLEPKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           *******************999999999987777..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRIMEvflvpadpqcrpiqyrvtvplmgaisdlcealsklsgiaaenmvvtdvynhrfhkifqmdeglshitprddifvye 566
           ********99888**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vcntsmdgsecitlpvyfrekksrpssassgavlygqpllvsvpkhkltleslyqavcdrisryikqplpdeflssplepgacngsrss 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  yegdeeeemdhqeegkeqlsevegsgeddqgddhsesaqkvkgqprhkrlftfslvnscgtadinslatdgkllklnsrstlaidwdse 744
           ***************************************************************************************** PP
   S: 186  ...............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq 243
                                           l++c+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++ 
   Q: 745  trslyfdeqeseacekhlsmsqpqkkkkaavALRECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY- 832
           ***********************************************************************************99885. PP
   S: 244  ksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgsta 330
             r k+++ vefp + L++s+f+++++    +++ Y+Liav +H+G ++ GHY+ay+kn  +gkW++fdDs+V+  +e+++++   + a
   Q: 833  -WRDKLDTVVEFPVRaLNMSEFVCDRSA---RPYVYDLIAVSNHYGAMGVGHYTAYAKNrLNGKWYYFDDSSVSLASEDQIVT---KAA 914
           .567*****************9999554...49**************************55677*******************...*** PP
   S: 331  YvlfYkrr 338
           YvlfY+rr
   Q: 915  YVLFYQRR 922
           ******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTIQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Mus musculus

Functional Description
(View)

Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.

Protein Sequence
(Fasta)

MAEGRGSRER PDVETQKTEL GALMGTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPAEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCCCATA GCACGCCGTG CGCTAGGCGG ATGTCCGGGC CGGCTGGGCC GGGGCGGCGG 60
ACGAGATGGC GGAAGGCCGG GGCAGCCGTG AGCGACCGGA TGTGGAGACC CAGAAGACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031685--F:adenosine receptor binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:22258

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	90.35	0.00e+00	1640.00
IUUC-Atr-002991	Amborella trichopoda	35.77	4.00e-144	505.00
IUUC-Apl-004068	Anas platyrhynchos	70.76	0.00e+00	1207.00
IUUC-Aca-004459	Anolis carolinensis	68.10	0.00e+00	1254.00
IUUC-Ath-007560	Arabidopsis thaliana	37.31	4.00e-147	515.00
IUUC-Ago-007911	Ashbya gossypii	37.71	5.00e-63	236.00
IUUC-Acl-008284	Aspergillus clavatus	39.52	2.00e-55	211.00
IUUC-Afu-008878	Aspergillus fumigatus	37.14	2.00e-55	212.00
IUUC-Ani-009479	Aspergillus nidulans	43.37	3.00e-52	201.00
IUUC-Ang-009562	Aspergillus niger	44.40	2.00e-56	215.00
IUUC-Ate-010323	Aspergillus terreus	43.57	2.00e-54	208.00
IUUC-Bta-012929	Bos taurus	90.56	0.00e+00	1692.00
IUUC-Bdi-014013	Brachypodium distachyon	36.79	6.00e-153	535.00
IUUC-Bol-016335	Brassica oleracea	34.90	5.00e-137	482.00
IUUC-Bra-016930	Brassica rapa	34.72	9.00e-136	478.00
IUUC-Cel-018257	Caenorhabditis elegans	31.12	7.00e-94	339.00
IUUC-Cja-018798	Callithrix jacchus	89.30	0.00e+00	1627.00
IUUC-Cfa-020599	Canis familiaris	90.98	0.00e+00	1674.00
IUUC-Cpo-022144	Cavia porcellus	88.82	0.00e+00	1624.00
IUUC-Csa-023770	Chlorocebus sabaeus	90.53	0.00e+00	1552.00
IUUC-Cho-024595	Choloepus hoffmanni	81.28	0.00e+00	1053.00
IUUC-Cin-025292	Ciona intestinalis	43.75	0.00e+00	750.00
IUUC-Cne-026852	Cryptococcus neoformans	40.22	1.00e-73	271.00
IUUC-Dre-027869	Danio rerio	70.40	0.00e+00	894.00
IUUC-Dno-029316	Dasypus novemcinctus	88.38	0.00e+00	1655.00
IUUC-Ete-032970	Echinops telfairi	80.14	0.00e+00	1048.00
IUUC-Eca-034012	Equus caballus	90.65	0.00e+00	1655.00
IUUC-Eeu-035158	Erinaceus europaeus	76.18	0.00e+00	767.00
IUUC-Fca-035373	Felis catus	86.62	0.00e+00	1619.00
IUUC-Fal-037634	Ficedula albicollis	74.65	0.00e+00	1302.00
IUUC-Fox-037986	Fusarium oxysporum	42.67	2.00e-65	244.00
IUUC-Fso-038291	Fusarium solani	44.85	1.00e-64	242.00
IUUC-Gmo-038866	Gadus morhua	63.35	0.00e+00	1155.00
IUUC-Ggr-039740	Gaeumannomyces graminis	43.96	2.00e-62	234.00
IUUC-Gga-040729	Gallus gallus	70.35	0.00e+00	1256.00
IUUC-Gac-042631	Gasterosteus aculeatus	66.77	0.00e+00	1222.00
IUUC-Gma-043077	Glycine max	37.57	3.00e-154	539.00
IUUC-Ggo-045337	Gorilla gorilla	90.21	0.00e+00	1499.00
IUUC-Hsa-045669	Homo sapiens	90.76	0.00e+00	1666.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	92.21	0.00e+00	1721.00
IUUC-Lch-050533	Latimeria chalumnae	67.75	0.00e+00	1176.00
IUUC-Lpe-051424	Leersia perrieri	36.78	4.00e-153	535.00
IUUC-Laf-053803	Loxodonta africana	90.76	0.00e+00	1678.00
IUUC-Mcc-055556	Macaca mulatta	86.60	0.00e+00	1554.00
IUUC-Meu-056742	Macropus eugenii	70.79	0.00e+00	1302.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	3.00e-62	234.00
IUUC-Mpo-057486	Magnaporthe poae	44.69	2.00e-62	235.00
IUUC-Mtr-058138	Medicago truncatula	37.85	3.00e-157	549.00
IUUC-Mga-059300	Meleagris gallopavo	70.87	0.00e+00	1226.00
IUUC-Mdo-061848	Monodelphis domestica	81.82	0.00e+00	1527.00
IUUC-Mac-065239	Musa acuminata	34.46	1.00e-134	474.00
IUUC-Mpu-066920	Mustela putorius furo	90.98	0.00e+00	1674.00
IUUC-Mlu-068088	Myotis lucifugus	89.11	0.00e+00	1658.00
IUUC-Nfi-068330	Neosartorya fischeri	38.03	2.00e-55	212.00
IUUC-Ncr-068879	Neurospora crassa	31.78	7.00e-69	256.00
IUUC-Nle-070010	Nomascus leucogenys	90.76	0.00e+00	1661.00
IUUC-Opr-070740	Ochotona princeps	87.55	0.00e+00	1174.00
IUUC-Ont-072573	Oreochromis niloticus	65.44	0.00e+00	1245.00
IUUC-Oan-073363	Ornithorhynchus anatinus	75.08	0.00e+00	1403.00
IUUC-Ocu-074242	Oryctolagus cuniculus	85.57	0.00e+00	1560.00
IUUC-Oba-075553	Oryza barthii	41.19	1.00e-128	454.00
IUUC-Obr-076902	Oryza brachyantha	36.57	9.00e-149	521.00
IUUC-Ogl-077583	Oryza glaberrima	41.19	1.00e-128	454.00
IUUC-Ogu-077990	Oryza glumaepatula	40.38	3.00e-123	436.00
IUUC-Oin-079300	Oryza indica	41.34	1.00e-129	457.00
IUUC-Olo-080315	Oryza longistaminata	36.38	1.00e-146	514.00
IUUC-Ome-081271	Oryza meridionalis	36.19	7.00e-148	518.00
IUUC-Oni-082303	Oryza nivara	40.53	1.00e-123	437.00
IUUC-Oru-085141	Oryza rufipogon	40.94	8.00e-126	445.00
IUUC-Osa-085641	Oryza sativa	41.34	1.00e-129	457.00
IUUC-Ola-086553	Oryzias latipes	66.63	0.00e+00	1267.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.25	1.00e-125	443.00
IUUC-Oga-088562	Otolemur garnettii	84.22	0.00e+00	1451.00
IUUC-Oar-090439	Ovis aries	89.72	0.00e+00	1664.00
IUUC-Ptr-090801	Pan troglodytes	90.96	0.00e+00	1673.00
IUUC-Pan-092717	Papio anubis	85.48	0.00e+00	1524.00
IUUC-Psi-093942	Pelodiscus sinensis	73.36	0.00e+00	1288.00
IUUC-Pab-098522	Pongo abelii	88.71	0.00e+00	1196.00
IUUC-Pop-099313	Populus trichocarpa	37.18	1.00e-155	543.00
IUUC-Pca-100161	Procavia capensis	80.19	0.00e+00	1447.00
IUUC-Ppe-101587	Prunus persica	37.71	3.00e-153	535.00
IUUC-Rno-106081	Rattus norvegicus	95.53	0.00e+00	1811.00
IUUC-Sce-106170	Saccharomyces cerevisiae	37.61	6.00e-60	226.00
IUUC-Sha-106937	Sarcophilus harrisii	81.47	0.00e+00	1498.00
IUUC-Spo-108291	Schizosaccharomyces pombe	43.69	1.00e-73	271.00
IUUC-Sit-109948	Setaria italica	36.96	4.00e-142	499.00
IUUC-Sly-111746	Solanum lycopersicum	38.02	3.00e-155	542.00
IUUC-Stu-112671	Solanum tuberosum	37.61	7.00e-153	534.00
IUUC-Sar-113542	Sorex araneus	85.46	0.00e+00	1563.00
IUUC-Sbi-114874	Sorghum bicolor	36.17	9.00e-145	508.00
IUUC-Ssc-115637	Sus scrofa	90.56	0.00e+00	1662.00
IUUC-Tgu-117267	Taeniopygia guttata	71.67	0.00e+00	1306.00
IUUC-Tru-118634	Takifugu rubripes	66.74	0.00e+00	1194.00
IUUC-Tni-120107	Tetraodon nigroviridis	62.66	0.00e+00	1158.00
IUUC-Tca-121001	Theobroma cacao	36.47	1.00e-157	550.00
IUUC-Tae-125401	Triticum aestivum	35.19	2.00e-146	513.00
IUUC-Tme-127062	Tuber melanosporum	33.27	2.00e-78	287.00
IUUC-Tbe-127669	Tupaia belangeri	73.68	0.00e+00	895.00
IUUC-Ttr-128778	Tursiops truncatus	89.52	0.00e+00	1654.00
IUUC-Vda-129781	Verticillium dahliae	29.61	5.00e-70	260.00
IUUC-Vpa-130571	Vicugna pacos	93.88	0.00e+00	1135.00
IUUC-Vvi-131010	Vitis vinifera	38.88	6.00e-157	548.00
IUUC-Xtr-132305	Xenopus tropicalis	68.57	0.00e+00	1281.00
IUUC-Yli-134392	Yarrowia lipolytica	44.29	4.00e-63	237.00
IUUC-Zma-135699	Zea mays	36.07	1.00e-145	510.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence