iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063815

Ensembl Protein ID

ENSMUSP00000025250.7

UniProt Accession

Q9Z1R2; Q8SNA3; BAG6_MOUSE

Genbank Protein ID

AAC82479.1; AAH26647.1

Protein Name

Large proline-rich protein BAG6; BAG family molecular chaperone regulator 6; BCL2-associated athanogene 6; HLA-B-associated transcript 3; Protein Scythe

Genbank Nucleotide ID

AF109719; CR974444

Gene Name

Bag6; Bat3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000024392.17	ENSMUST00000166426.8	ENSMUSP00000129324.2
ENSMUSG00000024392.17	ENSMUST00000172571.7	ENSMUSP00000134175.1
ENSMUSG00000024392.17	ENSMUST00000173535.7	ENSMUSP00000133822.1
ENSMUSG00000024392.17	ENSMUST00000173952.7	ENSMUSP00000134717.2
ENSMUSG00000024392.17	ENSMUST00000174281.8	ENSMUSP00000134425.1
ENSMUSG00000024392.17	ENSMUST00000173550.7	ENSMUSP00000134628.1
ENSMUSG00000024392.17	ENSMUST00000172993.1	ENSMUSP00000138467.1
ENSMUSG00000024392.17	ENSMUST00000025250.13	ENSMUSP00000025250.7

Annotation

mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	TRANSFAC
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.00e-19	71.3	18	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 2    kltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           ++ vktl++++ ++ v  +++v+e+Ke+ia++ ++p e+q+LIy+G++L+Dd++L+e+++  g+v+hlv + ++
   Q: 18   EVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVG-GKVIHLVERAPP 90
           799*********************************************************9.*******99876 PP

Organism

Mus musculus

Functional Description
(View)

May mediate ricin-induced apoptosis.

Protein Sequence
(Fasta)

MEPSDSASTA MEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI 60
YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTQLPSGASS GTGSASATHG GAPLPGTRGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGTGTGCG CACGCGTGGC GCCGCTCACG CAGGCGCAGT GCGGTCCCCC GGGCGACGAC 60
GGCGGCGGCG GCGGCTCCTC CGGGTGGTCG GCTCCCTCCC ATCTCGGCCG GCCCGGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0053--Apoptosis
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0391--Immunity
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0744--Spermatogenesis
KW-0813--Transport

Interpro

IPR021925--DUF3538
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF12057--DUF3538
PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0071818--C:BAT3 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030544--F:Hsp70 protein binding
GO:0051787--F:misfolded protein binding
GO:0031593--F:polyubiquitin binding
GO:0070628--F:proteasome binding
GO:0043022--F:ribosome binding
GO:0015643--F:toxic substance binding
GO:0031625--F:ubiquitin protein ligase binding
GO:1990381--F:ubiquitin-specific protease binding
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0007420--P:brain development
GO:0030154--P:cell differentiation
GO:0016569--P:covalent chromatin modification
GO:0009790--P:embryo development
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0002429--P:immune response-activating cell surface receptor signaling pathway
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001822--P:kidney development
GO:0030324--P:lung development
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0030101--P:natural killer cell activation
GO:0043066--P:negative regulation of apoptotic process
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045861--P:negative regulation of proteolysis
GO:1904294--P:positive regulation of ERAD pathway
GO:0050821--P:protein stabilization
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0007283--P:spermatogenesis
GO:0007130--P:synaptonemal complex assembly
GO:0071816--P:tail-anchored membrane protein insertion into ER membrane
GO:0006810--P:transport
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:224727

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000364	Aegilops tauschii	44.74	2.00e-12	68.20
IUUC-Aml-001312	Ailuropoda melanoleuca	95.65	0.00e+00	763.00
IUUC-Atr-002741	Amborella trichopoda	39.26	2.00e-20	95.10
IUUC-Aca-005226	Anolis carolinensis	65.64	2.00e-166	580.00
IUUC-Aly-005932	Arabidopsis lyrata	41.43	1.00e-17	85.50
IUUC-Ath-006845	Arabidopsis thaliana	36.69	8.00e-16	79.30
IUUC-Acl-008361	Aspergillus clavatus	35.71	4.00e-08	53.10
IUUC-Afl-008403	Aspergillus flavus	38.64	3.00e-09	56.60
IUUC-Afu-009029	Aspergillus fumigatus	33.73	9.00e-08	51.60
IUUC-Ang-009826	Aspergillus niger	39.29	1.00e-10	60.80
IUUC-Aor-010091	Aspergillus oryzae	38.64	3.00e-09	56.60
IUUC-Ate-010419	Aspergillus terreus	37.21	3.00e-08	53.10
IUUC-Ame-011606	Astyanax mexicanus	55.27	1.00e-147	517.00
IUUC-Bta-012561	Bos taurus	92.84	0.00e+00	736.00
IUUC-Bdi-015055	Brachypodium distachyon	40.95	5.00e-13	69.70
IUUC-Bol-015438	Brassica oleracea	45.35	5.00e-15	76.60
IUUC-Bra-017388	Brassica rapa	39.37	2.00e-15	78.20
IUUC-Cja-019188	Callithrix jacchus	90.17	0.00e+00	663.00
IUUC-Cfa-021178	Canis familiaris	95.11	0.00e+00	747.00
IUUC-Cpo-022133	Cavia porcellus	96.83	0.00e+00	714.00
IUUC-Cin-025671	Ciona intestinalis	50.65	6.00e-15	74.30
IUUC-Dre-028559	Danio rerio	54.98	4.00e-155	542.00
IUUC-Dno-029388	Dasypus novemcinctus	97.30	0.00e+00	693.00
IUUC-Dor-030577	Dipodomys ordii	97.30	0.00e+00	696.00
IUUC-Dme-031599	Drosophila melanogaster	43.53	3.00e-17	84.70
IUUC-Ete-032733	Echinops telfairi	96.01	2.00e-157	550.00
IUUC-Eca-033397	Equus caballus	96.41	0.00e+00	749.00
IUUC-Eeu-034638	Erinaceus europaeus	97.00	0.00e+00	697.00
IUUC-Fca-036518	Felis catus	96.98	0.00e+00	779.00
IUUC-Gmo-038892	Gadus morhua	48.61	1.00e-120	427.00
IUUC-Gac-041284	Gasterosteus aculeatus	51.57	2.00e-134	474.00
IUUC-Gma-043104	Glycine max	43.62	4.00e-15	77.40
IUUC-Ggo-044420	Gorilla gorilla	97.35	0.00e+00	736.00
IUUC-Hsa-046336	Homo sapiens	97.54	0.00e+00	738.00
IUUC-Itr-048007	Ictidomys tridecemlineatus	89.57	0.00e+00	739.00
IUUC-Lch-049762	Latimeria chalumnae	53.78	3.00e-96	347.00
IUUC-Lpe-051531	Leersia perrieri	40.70	1.00e-11	65.50
IUUC-Laf-053832	Loxodonta africana	97.63	0.00e+00	730.00
IUUC-Mcc-055256	Macaca mulatta	97.35	0.00e+00	739.00
IUUC-Meu-056280	Macropus eugenii	86.01	9.00e-79	288.00
IUUC-Mtr-058642	Medicago truncatula	39.71	4.00e-16	80.50
IUUC-Mmr-061073	Microcebus murinus	93.19	0.00e+00	721.00
IUUC-Mdo-062059	Monodelphis domestica	85.63	0.00e+00	687.00
IUUC-Mac-064677	Musa acuminata	29.92	7.00e-06	46.60
IUUC-Mpu-066558	Mustela putorius furo	96.98	0.00e+00	785.00
IUUC-Mlu-067697	Myotis lucifugus	96.22	0.00e+00	724.00
IUUC-Nfi-068487	Neosartorya fischeri	33.73	7.00e-08	52.00
IUUC-Nle-068988	Nomascus leucogenys	96.79	0.00e+00	722.00
IUUC-Opr-071123	Ochotona princeps	96.03	0.00e+00	727.00
IUUC-Ont-072239	Oreochromis niloticus	51.08	3.00e-126	446.00
IUUC-Ocu-073903	Oryctolagus cuniculus	97.16	0.00e+00	724.00
IUUC-Oba-075736	Oryza barthii	42.27	6.00e-13	69.30
IUUC-Obr-076574	Oryza brachyantha	44.57	8.00e-13	68.60
IUUC-Ogl-077678	Oryza glaberrima	42.27	6.00e-13	69.30
IUUC-Ogu-078952	Oryza glumaepatula	42.27	8.00e-13	69.30
IUUC-Oin-079943	Oryza indica	42.27	8.00e-13	68.90
IUUC-Ome-081937	Oryza meridionalis	42.27	1.00e-12	68.90
IUUC-Oni-082471	Oryza nivara	42.27	7.00e-13	69.30
IUUC-Opu-083366	Oryza punctata	42.27	7.00e-13	69.30
IUUC-Oru-085170	Oryza rufipogon	42.27	8.00e-13	69.30
IUUC-Osa-085915	Oryza sativa	42.27	6.00e-13	68.20
IUUC-Ola-087116	Oryzias latipes	48.03	1.00e-115	411.00
IUUC-Oga-088614	Otolemur garnettii	96.98	0.00e+00	732.00
IUUC-Oar-090085	Ovis aries	92.66	0.00e+00	734.00
IUUC-Pan-091999	Papio anubis	97.35	0.00e+00	738.00
IUUC-Pno-094908	Phaeosphaeria nodorum	30.33	9.00e-09	54.30
IUUC-Ppa-095775	Physcomitrella patens	37.88	4.00e-16	80.50
IUUC-Pfo-097252	Poecilia formosa	48.87	4.00e-126	446.00
IUUC-Pab-098493	Pongo abelii	97.35	0.00e+00	736.00
IUUC-Pop-099480	Populus trichocarpa	49.43	1.00e-16	82.40
IUUC-Ppe-101620	Prunus persica	46.59	2.00e-14	75.10
IUUC-Pva-103214	Pteropus vampyrus	95.84	0.00e+00	719.00
IUUC-Rno-105636	Rattus norvegicus	98.11	0.00e+00	735.00
IUUC-Sha-106964	Sarcophilus harrisii	86.88	0.00e+00	662.00
IUUC-Smo-108772	Selaginella moellendorffii	39.66	8.00e-14	72.40
IUUC-Sit-110231	Setaria italica	43.88	4.00e-13	70.10
IUUC-Sly-111457	Solanum lycopersicum	39.10	2.00e-16	81.30
IUUC-Sar-113198	Sorex araneus	97.14	7.00e-164	571.00
IUUC-Sbi-114712	Sorghum bicolor	42.00	2.00e-12	67.80
IUUC-Ssc-116256	Sus scrofa	88.49	0.00e+00	718.00
IUUC-Tru-118440	Takifugu rubripes	52.18	5.00e-112	399.00
IUUC-Tsy-119351	Tarsius syrichta	90.55	0.00e+00	648.00
IUUC-Tca-121642	Theobroma cacao	47.62	3.00e-14	74.30
IUUC-Tae-125387	Triticum aestivum	44.74	2.00e-12	68.60
IUUC-Tbe-127897	Tupaia belangeri	98.29	1.00e-152	534.00
IUUC-Ttr-128389	Tursiops truncatus	97.30	0.00e+00	697.00
IUUC-Vvi-130920	Vitis vinifera	48.00	1.00e-14	75.50
IUUC-Xtr-132680	Xenopus tropicalis	58.04	4.00e-150	525.00
IUUC-Xma-133181	Xiphophorus maculatus	59.04	4.00e-51	195.00
IUUC-Yli-134630	Yarrowia lipolytica	37.66	5.00e-10	58.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence