iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027557

UUCD1 version

UUC-DaR-01220

Ensembl Protein ID

ENSDARP00000036715.4

UniProt Accession

Q6IWL4; Q1MTB3; Q7SXX1; TRAF6_DANRE

Genbank Protein ID

AAT37634.1; CAK11108.1; AAH55214.1; AAI71483.1; AAI71487.1

Protein Name

TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6

Genbank Nucleotide ID

AY616583; AL929208; BC055214; BC171483; BC171487

Gene Name

traf6; si:dkey-56p7.3; zgc:63704

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000028058.5	ENSDART00000038273.5	ENSDARP00000036715.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.60e-06	29.0	67	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r  v +p+G+ +  s+I+k +++ g++cPv+++ l ee+l P ++ +r i
   Q: 67   SKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNFAKREI 128
           5689*****************************999999*****************999977 PP

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.

Protein Sequence
(Fasta)

MACNDVDKSS FDDVCCDSGH SSCAAAMEKE RESFLSPTEN PSTISVSSSM PPDQQGYDVE 60
FDPPLESKYE CPICLMGLRS AVQTPCGHRF CDSCIRKSIR DTGQKCPVDN EVLLEEQLFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGACGTTG CGCAAGTGAT GTTTAGAGTA ACTTTACAGG AAGCAGCAGT ATAGGCGCGC 60
GAGGCCGTAC CGAGCCAATG TAAGTAAATG AAAACTATTA CGAATAATAT ATGTCTATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0009617--P:response to bacterium
GO:0009615--P:response to virus
GO:0007165--P:signal transduction

KEGG

dre:554561

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	59.60	4.00e-171	594.00
IUUC-Apl-004062	Anas platyrhynchos	59.27	9.00e-176	610.00
IUUC-Aca-004636	Anolis carolinensis	58.22	1.00e-175	609.00
IUUC-Aly-006415	Arabidopsis lyrata	28.93	4.00e-08	53.10
IUUC-Ath-007062	Arabidopsis thaliana	28.30	3.00e-07	50.40
IUUC-Ame-011682	Astyanax mexicanus	73.15	0.00e+00	808.00
IUUC-Bta-012692	Bos taurus	60.00	2.00e-177	615.00
IUUC-Bdi-014180	Brachypodium distachyon	24.39	8.00e-09	55.10
IUUC-Cja-019426	Callithrix jacchus	58.61	4.00e-171	594.00
IUUC-Cfa-020948	Canis familiaris	58.18	2.00e-148	519.00
IUUC-Cpo-021378	Cavia porcellus	59.55	2.00e-172	598.00
IUUC-Csa-024045	Chlorocebus sabaeus	59.21	5.00e-175	607.00
IUUC-Cho-024973	Choloepus hoffmanni	46.56	1.00e-55	211.00
IUUC-Csv-026300	Ciona savignyi	39.32	1.00e-44	173.00
IUUC-Dno-030032	Dasypus novemcinctus	57.76	3.00e-85	308.00
IUUC-Dor-030790	Dipodomys ordii	59.09	2.00e-173	602.00
IUUC-Dme-031921	Drosophila melanogaster	34.00	4.00e-20	92.80
IUUC-Ete-032952	Echinops telfairi	55.56	2.00e-105	376.00
IUUC-Eca-033924	Equus caballus	54.44	5.00e-149	521.00
IUUC-Eeu-034734	Erinaceus europaeus	53.16	4.00e-151	528.00
IUUC-Fca-036222	Felis catus	56.67	3.00e-157	548.00
IUUC-Fal-036834	Ficedula albicollis	60.08	2.00e-164	572.00
IUUC-Fox-037935	Fusarium oxysporum	29.49	7.00e-18	85.50
IUUC-Gmo-039061	Gadus morhua	67.84	1.00e-100	360.00
IUUC-Ggr-040084	Gaeumannomyces graminis	24.66	1.00e-14	74.70
IUUC-Gga-040599	Gallus gallus	59.25	7.00e-180	624.00
IUUC-Gac-041977	Gasterosteus aculeatus	63.99	0.00e+00	689.00
IUUC-Ggo-044508	Gorilla gorilla	56.97	2.00e-159	555.00
IUUC-Hsa-046349	Homo sapiens	56.35	2.00e-175	608.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	55.62	3.00e-172	598.00
IUUC-Lch-049821	Latimeria chalumnae	62.01	0.00e+00	635.00
IUUC-Loc-051995	Lepisosteus oculatus	66.40	0.00e+00	673.00
IUUC-Laf-054115	Loxodonta africana	57.53	2.00e-168	585.00
IUUC-Mcc-055298	Macaca mulatta	59.21	2.00e-174	605.00
IUUC-Mor-057263	Magnaporthe oryzae	29.30	1.00e-17	84.70
IUUC-Mpo-057517	Magnaporthe poae	26.96	2.00e-14	73.90
IUUC-Mga-059340	Meleagris gallopavo	60.43	7.00e-176	610.00
IUUC-Mmr-061063	Microcebus murinus	59.15	1.00e-170	593.00
IUUC-Mdo-062075	Monodelphis domestica	55.81	6.00e-168	583.00
IUUC-Mmu-063780	Mus musculus	59.35	5.00e-171	594.00
IUUC-Mpu-065748	Mustela putorius furo	59.41	2.00e-170	592.00
IUUC-Mlu-067888	Myotis lucifugus	58.42	1.00e-174	606.00
IUUC-Ncr-068632	Neurospora crassa	25.91	6.00e-16	79.30
IUUC-Nle-069234	Nomascus leucogenys	58.81	2.00e-173	602.00
IUUC-Opr-070393	Ochotona princeps	61.97	5.00e-78	285.00
IUUC-Ont-072459	Oreochromis niloticus	63.89	0.00e+00	731.00
IUUC-Oan-073578	Ornithorhynchus anatinus	58.51	3.00e-177	614.00
IUUC-Ocu-074201	Oryctolagus cuniculus	59.41	3.00e-175	608.00
IUUC-Oba-075263	Oryza barthii	26.13	4.00e-08	52.40
IUUC-Ogu-078582	Oryza glumaepatula	25.63	9.00e-08	51.20
IUUC-Oin-079499	Oryza indica	25.63	9.00e-08	51.20
IUUC-Opu-083468	Oryza punctata	30.67	6.00e-09	55.10
IUUC-Ola-087319	Oryzias latipes	69.23	3.00e-105	375.00
IUUC-Oga-087936	Otolemur garnettii	58.22	3.00e-171	595.00
IUUC-Oar-089379	Ovis aries	59.80	8.00e-177	613.00
IUUC-Ptr-090758	Pan troglodytes	59.01	5.00e-174	603.00
IUUC-Pan-092590	Papio anubis	59.01	6.00e-174	603.00
IUUC-Psi-093948	Pelodiscus sinensis	58.14	2.00e-177	615.00
IUUC-Pma-094434	Petromyzon marinus	45.07	1.00e-115	410.00
IUUC-Pfo-096912	Poecilia formosa	63.05	0.00e+00	687.00
IUUC-Pab-097651	Pongo abelii	59.01	6.00e-174	604.00
IUUC-Pca-100958	Procavia capensis	53.16	2.00e-118	419.00
IUUC-Pva-103247	Pteropus vampyrus	63.68	8.00e-76	278.00
IUUC-Rno-104994	Rattus norvegicus	59.60	5.00e-174	604.00
IUUC-Sha-106494	Sarcophilus harrisii	56.20	7.00e-170	590.00
IUUC-Sit-109710	Setaria italica	26.04	3.00e-09	55.80
IUUC-Sar-113375	Sorex araneus	57.99	5.00e-170	590.00
IUUC-Ssc-115417	Sus scrofa	60.92	5.00e-176	610.00
IUUC-Tgu-117232	Taeniopygia guttata	60.72	3.00e-177	615.00
IUUC-Tru-118321	Takifugu rubripes	62.83	0.00e+00	707.00
IUUC-Tni-120475	Tetraodon nigroviridis	62.72	0.00e+00	669.00
IUUC-Tur-126245	Triticum urartu	24.36	2.00e-11	63.50
IUUC-Tbe-127719	Tupaia belangeri	49.41	4.00e-135	474.00
IUUC-Ttr-129264	Tursiops truncatus	63.21	3.00e-75	276.00
IUUC-Vda-129938	Verticillium dahliae	24.82	8.00e-18	85.50
IUUC-Vpa-130244	Vicugna pacos	65.09	6.00e-76	278.00
IUUC-Xtr-131948	Xenopus tropicalis	55.96	8.00e-173	600.00
IUUC-Xma-133132	Xiphophorus maculatus	61.54	0.00e+00	676.00
IUUC-Yli-134356	Yarrowia lipolytica	26.78	1.00e-13	70.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence