iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089379

Ensembl Protein ID

ENSOARP00000020492.1

UniProt Accession

W5QCP4; W5QCP4_SHEEP

Genbank Protein ID

ENSOARP00000020492

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01032942

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000019079.1	ENSOART00000020775.1	ENSOARP00000020492.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.90e-07	29.9	67	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 67   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 128
           5689*****************************999999*****************999977 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MSLLHCENSC GSSQSESDCC AAMAASACGT AAKDDSVSGA ASTVTLSSSF MEEIQGYDVE 60
FDPPLESKYE CPICLMALRE AVQTPCGHRF CKACIIKSIR DAGHKCPVDN EILLENQLFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGC TACACTGTGA AAACAGCTGC GGATCCAGCC AGTCCGAGAG CGACTGCTGC 60
GCCGCCATGG CCGCCAGCGC CTGTGGGACC GCAGCAAAAG ACGACAGTGT GAGCGGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

oas:101107132

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	92.24	0.00e+00	970.00
IUUC-Apl-004062	Anas platyrhynchos	73.45	0.00e+00	818.00
IUUC-Aca-004636	Anolis carolinensis	70.49	0.00e+00	775.00
IUUC-Ame-011682	Astyanax mexicanus	55.73	3.00e-165	575.00
IUUC-Bta-012692	Bos taurus	98.52	0.00e+00	1073.00
IUUC-Bci-013998	Botrytis cinerea	26.67	5.00e-14	72.40
IUUC-Cja-019426	Callithrix jacchus	87.08	0.00e+00	949.00
IUUC-Cfa-020948	Canis familiaris	90.20	0.00e+00	863.00
IUUC-Cpo-021378	Cavia porcellus	89.34	0.00e+00	959.00
IUUC-Csa-024045	Chlorocebus sabaeus	88.38	0.00e+00	969.00
IUUC-Cho-024973	Choloepus hoffmanni	73.12	1.00e-98	353.00
IUUC-Csv-026300	Ciona savignyi	42.42	8.00e-48	183.00
IUUC-Dre-027557	Danio rerio	59.80	5.00e-177	613.00
IUUC-Dno-030032	Dasypus novemcinctus	85.63	1.00e-146	511.00
IUUC-Dor-030790	Dipodomys ordii	86.90	0.00e+00	944.00
IUUC-Dme-031921	Drosophila melanogaster	27.17	5.00e-41	162.00
IUUC-Ete-032952	Echinops telfairi	83.78	7.00e-168	583.00
IUUC-Eca-033924	Equus caballus	85.66	0.00e+00	874.00
IUUC-Eeu-034734	Erinaceus europaeus	80.48	0.00e+00	845.00
IUUC-Fca-036222	Felis catus	84.71	0.00e+00	869.00
IUUC-Fal-036834	Ficedula albicollis	74.95	0.00e+00	742.00
IUUC-Fox-037935	Fusarium oxysporum	30.23	5.00e-22	99.00
IUUC-Gmo-039061	Gadus morhua	61.38	2.00e-87	316.00
IUUC-Ggr-040084	Gaeumannomyces graminis	26.24	2.00e-13	70.90
IUUC-Gga-040599	Gallus gallus	74.68	0.00e+00	827.00
IUUC-Gac-041977	Gasterosteus aculeatus	53.88	2.00e-168	585.00
IUUC-Ggo-044508	Gorilla gorilla	82.90	0.00e+00	884.00
IUUC-Hsa-046349	Homo sapiens	88.56	0.00e+00	978.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	88.01	0.00e+00	956.00
IUUC-Lch-049821	Latimeria chalumnae	66.37	0.00e+00	742.00
IUUC-Loc-051995	Lepisosteus oculatus	63.01	0.00e+00	649.00
IUUC-Laf-054115	Loxodonta africana	86.16	0.00e+00	959.00
IUUC-Mcc-055298	Macaca mulatta	88.38	0.00e+00	968.00
IUUC-Mor-057263	Magnaporthe oryzae	31.48	1.00e-19	91.30
IUUC-Mpo-057517	Magnaporthe poae	29.27	6.00e-16	79.00
IUUC-Mga-059340	Meleagris gallopavo	74.31	0.00e+00	820.00
IUUC-Mvi-060553	Microbotryum violaceum	28.57	5.00e-15	75.50
IUUC-Mmr-061063	Microcebus murinus	89.48	0.00e+00	959.00
IUUC-Mdo-062075	Monodelphis domestica	79.45	0.00e+00	874.00
IUUC-Mmu-063780	Mus musculus	82.84	0.00e+00	894.00
IUUC-Mpu-065748	Mustela putorius furo	92.07	0.00e+00	982.00
IUUC-Mlu-067888	Myotis lucifugus	87.64	0.00e+00	946.00
IUUC-Ncr-068632	Neurospora crassa	28.22	4.00e-17	83.20
IUUC-Nle-069234	Nomascus leucogenys	88.56	0.00e+00	973.00
IUUC-Opr-070393	Ochotona princeps	95.77	1.00e-122	433.00
IUUC-Ont-072459	Oreochromis niloticus	57.17	5.00e-176	610.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.47	0.00e+00	906.00
IUUC-Ocu-074201	Oryctolagus cuniculus	89.11	0.00e+00	961.00
IUUC-Ola-087319	Oryzias latipes	62.55	7.00e-88	317.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.29	2.00e-10	60.10
IUUC-Oga-087936	Otolemur garnettii	86.72	0.00e+00	940.00
IUUC-Ptr-090758	Pan troglodytes	88.93	0.00e+00	972.00
IUUC-Pan-092590	Papio anubis	88.56	0.00e+00	969.00
IUUC-Psi-093948	Pelodiscus sinensis	72.13	0.00e+00	806.00
IUUC-Pma-094434	Petromyzon marinus	44.42	7.00e-124	437.00
IUUC-Pfo-096912	Poecilia formosa	56.27	2.00e-167	582.00
IUUC-Pab-097651	Pongo abelii	88.93	0.00e+00	975.00
IUUC-Pca-100958	Procavia capensis	84.44	0.00e+00	702.00
IUUC-Pva-103247	Pteropus vampyrus	87.75	1.00e-125	443.00
IUUC-Pte-104279	Pyrenophora teres	25.57	9.00e-13	68.90
IUUC-Rno-104994	Rattus norvegicus	81.73	0.00e+00	908.00
IUUC-Sha-106494	Sarcophilus harrisii	81.00	0.00e+00	893.00
IUUC-Ssl-108580	Sclerotinia sclerotiorum	26.27	1.00e-13	71.20
IUUC-Sar-113375	Sorex araneus	85.64	0.00e+00	917.00
IUUC-Sre-115218	Sporisorium reilianum	26.61	4.00e-15	76.60
IUUC-Ssc-115417	Sus scrofa	92.79	0.00e+00	998.00
IUUC-Tgu-117232	Taeniopygia guttata	73.26	0.00e+00	797.00
IUUC-Tru-118321	Takifugu rubripes	55.86	6.00e-166	577.00
IUUC-Tni-120475	Tetraodon nigroviridis	55.69	1.00e-164	572.00
IUUC-Tbe-127719	Tupaia belangeri	77.39	0.00e+00	810.00
IUUC-Ttr-129264	Tursiops truncatus	92.89	6.00e-127	447.00
IUUC-Uma-129620	Ustilago maydis	25.76	8.00e-17	82.40
IUUC-Vpa-130244	Vicugna pacos	91.30	1.00e-129	456.00
IUUC-Xtr-131948	Xenopus tropicalis	65.05	0.00e+00	737.00
IUUC-Xma-133132	Xiphophorus maculatus	56.97	1.00e-169	589.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence